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Povidone-IodineWiki

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Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)

Name (Synonyms) Correlation
drug882 Use of social media during COVID-19 Wiki 1.00

Correlated MeSH Terms (2)

Name (Synonyms) Correlation
D003863 Depression, NIH 0.41
D018352 Coronavirus Infections NIH 0.06

Correlated HPO Terms (0)

Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials

1 Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Naso- Pharyngeal Viral Load in Patients With SARS-CoV-2

The SARS-CoV-2 coronavirus pandemic is responsible for more than 180,000 deaths worldwide and 20,000 deaths in France. To date, no treatment or vaccine has been successful. Povidone-iodine is an antiseptic suitable for use on the skin and mucosa with potent virucidal activity, particularly against coronaviruses. It is marketed for oro-nasopharyngeal decolonization. 24 patients with positive nasopharyngeal SARS-CoV-2 carriage will be randomized (1:1) in an experimental group (benefiting from povidone iodine decolonization) or a control group. Patients in the experimental group will be asked to gargle with a 1% povidone-iodine solution, spray their nose with the same antiseptic solution, and finally applied 10% povidone-iodine cream in each nostril, all four times a day for five days. Patients will be followed for 7 days to evaluate the efficacy and safety of povidone iodine decolonization.

NCT04371965 COVID-19 Drug: Povidone-Iodine

Primary Outcomes

Measure: Change from baseline naso-pharyngeal viral load quantified by RT-PCR at Day7

Time: Day 7

Secondary Outcomes

Measure: Delay between inclusion and negativation of SARS-CoV-2 nasopharyngeal carriage

Time: Day0, Day1, Day3, Day5 and Day7

Measure: Delay between inclusion and negativation of SARS-CoV-2 nasopharyngeal cell cultures

Time: Day0, Day1, Day3, Day5 and Day7

Measure: Thyroid tests at Day0 and Day7

Time: Day0 and Day7

Measure: Patient satisfaction at Day7 using a numerical comfort scale, graduated from 0 (any discomfort) to 10 (maximum possible discomfort)

Time: Day7

Measure: Daily presence of clinical signs in favour of COVID-19, including respiratory distress using NYHA scale, chest pain, anosmia, agueusia, tiredness, cough, stiffness, nasal congestion, dysphagia and diarrhea

Time: Day0, Day1, Day3, Day5 and Day7

Measure: Need for ward or intensive care hospitalization

Time: Day0, Day1, Day3, Day5 and Day7

No related HPO nodes (Using clinical trials)