SNPMiner Trials by Shray Alag


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Report for Mutation S253N

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Association of 5-HT3 Receptor Gene Polymorphism With the Efficiency of Ondansetron for Postoperative Nausea and Vomiting

Postoperative nausea and vomiting (PONV) is a common and distressing complication in patients undergoing general anesthesia. However, although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, it is reported that over 35% of patients treated with ondansetron experience PONV. Though the cause of failure in ondansetron treatment is not clear, the investigators assumed that polymorphism in the 5-HT3 receptor gene would contribute to such inter-individual variation. In this study, the investigators examine whether the polymorphisms of 5-HT3 receptor gene affect the efficacy of ondansetron to prevent PONV in patients undergoing general anesthesia for laparoscopic surgery.

NCT01657786 Post Operative Nausea and Vomiting Dietary Supplement: administration of ondanstron and screening of genomic DNA
MeSH:Nausea Vomiting Postoperative Nausea and Vomiting
HPO:Nausea Vomiting

The relationship between the incidence of PONV after ondansetron administration and genotypes in 5-HT3 receptor gene polymorphisms ((5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG). --- S253N ---

The incidence of PONV after ondansetron administration is compared among genotypes in 5-HT3 receptor gene polymorphisms (5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG).. Inclusion Criteria: - Adult patients (20-90 years of age) scheduled for undergoing laparoscopic surgery undergoing general anesthesia Exclusion Criteria: - Patients with previous history of drug allergy, - administration of antiemetic drugs within 24 hours, - nausea/vomiting within 24 hours and liver or kidney disease Inclusion Criteria: - Adult patients (20-90 years of age) scheduled for undergoing laparoscopic surgery undergoing general anesthesia Exclusion Criteria: - Patients with previous history of drug allergy, - administration of antiemetic drugs within 24 hours, - nausea/vomiting within 24 hours and liver or kidney disease Post Operative Nausea and Vomiting Nausea Vomiting Postoperative Nausea and Vomiting null --- S253N ---

Primary Outcomes

Description: The incidence of PONV after ondansetron administration is compared among genotypes in 5-HT3 receptor gene polymorphisms (5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG).

Measure: The relationship between the incidence of PONV after ondansetron administration and genotypes in 5-HT3 receptor gene polymorphisms ((5-HT3a: S253N; 5-HT3b: Y129S, -100_-102delAAG)

Time: at first 2 h and 2-24 h after surgery.


HPO Nodes


HP:0002013: Vomiting
Genes 284
PPM1D SHANK3 ABCC8 KMT2E SLC6A8 NDUFAF5 BCKDHB KCNJ1 CPT2 ELP1 NEUROG3 RANBP2 CPOX NAGS SLC25A13 MVK COX1 MPI SLC22A5 STK11 ND2 CPS1 POLG SCNN1A ALG11 NDUFV1 TRNF CTNS RELA OTC PNPLA8 ND3 PCCB ACAT1 ATP6V0A4 CLMP BOLA3 DBT SERPING1 TYMP TRNC SCNN1B HSD3B2 NEUROG3 MTRR PDCD10 SAA1 HADH DBH ALG11 SERPING1 ACY1 NFIX TRNK TRNL1 ND1 ND4 NDUFS3 RRM2B NDUFV2 ALDOB SCNN1A ALDH18A1 HIBCH ND1 PHGDH ADNP COQ2 NAXD POLG COX3 TRNQ MPV17 RET MMUT SLC7A7 NDUFB11 TCN2 CFI NDUFS1 MRAP FARSB SUGCT PDSS2 CYTB PCCA TRNV CYP11A1 TIMMDC1 NDUFAF8 NDUFB10 HMGCL KCNJ11 ALDOB COX3 ASL ACADVL ATP6 ACADL F12 TNFRSF1A ABCC8 CYP11B2 MLYCD DGAT1 ATRX OPLAH GLA MTHFD1 CYP11A1 NDUFS6 SSR4 EGFR FOXRED1 CDH23 NBAS TRNS2 CCM2 ND1 GALC NDUFS4 NDUFAF4 TRNQ AQP2 GK BCKDHA SERPING1 CACNA1A SPP1 ETFA TXNRD2 ASS1 FBP1 MET TRNS1 MRPS7 CTNNB1 ACAT1 PMM2 COA8 AVPR2 ND5 ESR1 TP53 MVK TRNH NDUFS8 NAGS NDUFAF3 TMEM126B ACSF3 STAR PIGY GALT RARS1 AIMP1 ETFB HLCS MMAA COX2 TRNF CDK8 HNF1A HFE SAR1B ALG3 TRNW MCCC1 GCDH FLNA DGUOK MC2R MMAB ALAD DHCR7 POLG ACP2 GALC BRAF SCNN1G STAT4 NDUFA6 KCNJ11 SLC25A15 D2HGDH ST3GAL5 INHBA IVD NDUFS2 NDUFV1 CFH TRNS2 UCP2 APC NNT HNF4A ARG1 ACSF3 SYT1 NDUFS4 COX1 TRNW TNF TYMP ND5 NDUFA1 ACADM MSX2 SLC25A15 NDUFA11 IRAK1 MEN1 CYP24A1 ALX4 ZEB2 LPL HMGCS2 ND6 SLC12A3 PPOX CYTB ETFDH ND5 SLC22A5 HMGCL NDUFAF1 SLC1A3 ND4 ASPA SMPD1 AVP NDUFAF2 C11ORF95 FOXP3 NR3C2 HMBS TRNL1 NDUFS1 DLD ND3 ACADVL HELLPAR ALPL TRNK SLC12A1 TRNW NDUFB3 ND6 ND2 OXCT1 TRNS1 NDUFB9 COX2 GHSR AIP HPRT1 ACTG2 SLC7A7 TRNV PSAP EDNRA TRMU CDH23 SCNN1G CD46 CD55 PYCR2 SAR1B KRIT1 CYP11B1 ACAD8 ALG8 BTD GALE ND6 MCCC2 PMM2 TRNL1 NDUFS7 ACADM SCNN1B LIPA ND1 NUBPL
Protein Mutations 3
S253N V158M Y129S
SNP 1
rs4680