SNPMiner Trials by Shray Alag

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SNPMiner SNPMiner Trials (Home Page)


Report for Mutation P243R

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 An Open-Label Phase 2 Pilot Study Evaluating the Activity and Safety of FP 1039 in Subjects With Advanced and/or Recurrent Endometrial Cancers With Specific FGFR2 Mutations

An open-label, non-randomized, single arm study to assess the safety, tolerability, and pharmacokinetics of FP-1039 given by weekly intravenous (IV) administrations in advanced endometrial cancer patients with FGFR2-specific mutations. FP-1039 will be dosed weekly starting at a dose of up to 16 mg/kg.

NCT01244438
Conditions
  1. Endometrial Cancers With FGFR2 Mutations
Interventions
  1. Drug: FP-1039
MeSH:Endometrial Neoplasms
HPO:Endometrial carcinoma

Evidence of histologically or cytologically proven metastatic or locally advanced unresectable endometrial cancer bearing either the S252W or the P243R FGFR2 mutation. --- S252W --- --- P243R ---

Primary Outcomes

Description: To assess the response rate of advanced endometrial cancer patients bearing FGFR-specific mutations

Measure: Response rate

Time: up to 1 year

Description: To assess 6-month progression free survival of advanced endometrial cancer patients bearing FGFR-specific mutations

Measure: Progression-free survival

Time: 6 months

Secondary Outcomes

Description: To evaluate the safety and tolerability of FP-1039 in subjects with advanced endometrial cancer

Measure: Safety and tolerability

Time: up to 1 year

Description: To determine pharmacokinetics (PK) plasma concentration at specified times

Measure: Pharmacokinetics of Plasma

Time: up to 1 year


HPO Nodes