CovidResearchTrials by Shray Alag


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Report for D003967: Diarrhea NIH

(Synonyms: Diarrhea)

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug752 SivoMixx (200 billion) Wiki 0.71
drug960 hydroxychloroquine Wiki 0.58
drug82 Azithromycin Wiki 0.21

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D011014 Pneumonia NIH 0.08

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 Evaluation of the Impact of Bacteriotherapy in the Treatment of COVID-19

In light of its high morbidity and mortality, COronaVIrus Disease 19 (COVID-19) pandemic spread is considered an unprecedented global health challenge. Given the very limited therapeutic options available against Severe Acute Respiratory Syndrome - CoronaVirus-2 (SARS-CoV-2) epidemic at this time, the evaluation of new resources, designed in the first instance for other pathologies but potentially active against COVID-19, represents a priority in clinical research. This is an observational, retrospective, non-profit study on the adjuvant use of bacteriotherapy in the early control of disease progression in patients affected by COVID-19 and treated with the current standard of care on the basis of the interim guidelines of the Italian Society of Infectious and Tropical Diseases. The main purpose of the study is to evaluate the effectiveness of bacteriotherapy in reducing the clinical impact of acute diarrhea, containing the progression of COVID-19 and preventing the need for hospitalization in intensive care units.

NCT04368351 COVID Pneumonia Diarrhea Dietary Supplement: SivoMixx (200 billion) Drug: Azithromycin Drug: hydroxychloroquine
MeSH:Pneumonia Diarrhea
HPO:Diarrhea Pneumonia

Primary Outcomes

Description: Comparison between the two groups. Acute diarrhea was defined as a stool with increased water content, volume, or frequency that lasts less than 14 days.

Measure: delta of time of disappearance of acute diarrhea

Time: 21 days

Secondary Outcomes

Description: Comparison between the two groups

Measure: Delta in the number of patients requiring orotracheal intubation despite treatment

Time: 21 days

Description: Comparison between the two groups

Measure: Delta of crude mortality

Time: 21 days

Description: Comparison between the two groups

Measure: Delta of length of stay for patients in hospital

Time: 21 days


HPO Nodes


HP:0002014: Diarrhea
Genes 352
PCSK1 MPV17 SON AK2 CYP27A1 HNF1A ERCC2 BTK LIG4 STX3 PALLD TCIRG1 RNF168 TYMP GREM1 ANTXR2 IGKC GINS1 RFX5 TERT PTEN PKP1 WIPF1 SLC25A13 RFXANK TYMP HYOU1 HLA-B CPT1A ENG FBP1 SERPING1 BMPR1A TGFB1 MAOA SDHD ACTG2 HMGCL CD55 TREH IDS STAT4 CDKN2B TLK2 PMM2 WAS BMPR1A DNAJC6 C5 AP1S1 SCNN1B CD247 CDKN2C TSHR BMPR1A GFI1 NBN ITGA2 ENG HSD3B7 NAXD RFXANK IFNGR1 NOD2 SUGCT NOD2 HEXB IL21R RFXAP TTC7A SLC39A4 IL2RB DDC CYP7B1 STAT1 ABCC8 ANTXR2 RIPK1 OPLAH RECQL4 SLC9A3 SMAD4 PHKB RAG2 LCT ALG8 MLYCD SLC7A7 ALDOB SLC19A2 MYD88 CCDC47 GLA IDUA GP1BA SI BRCA2 BTD SERPING1 CPOX NEUROG3 IL10RA CIITA SEMA3C ABCB4 ADA PLVAP UCHL1 SAMD9 SCNN1G ALAD WNT2B CIITA TNFRSF1A IL7R LCK ICOS MEN1 RET MEFV PARK7 NAGLU PIGT RAG2 COG4 SCNN1A IGHM SLC46A1 PLEC ETHE1 PTPRC LIG4 TP53 BLM ACAT1 SLC10A2 MC2R RFX5 RAG2 ITCH DNASE1L3 CFH EGFR IL2RG COG6 CYP11B2 TTR PODXL SLC39A4 ELP1 HTRA2 RNF113A ACSF3 HGSNAT CD3E ADA ATP7A TCF3 MEN1 MYO5B ACADM SLC26A3 AVP SEMA3D ZAP70 TSHR SAR1B IGHM AGA TCN2 CDKN2A NBN POLG MCM6 ADAM17 DGAT1 DES ECE1 TTC37 CD247 NAGS CFHR1 SLC7A7 NRTN BLNK TXNRD2 BLNK CR2 ATP8B1 ITGB4 RAG1 SNCA TTC37 ARX GNS SERPING1 CD79B RAG1 GP1BB VPS13C CD79A TFRC EFL1 NNT UCP2 SRP54 NLRC4 FOXP3 RET LRBA KIF1B CD3D MYO5B CYP27A1 KRAS TNFRSF13B C1R LIPA DCLRE1C DBH DCLRE1C SKIV2L PRKN LRRC8A ICOS NSUN2 CTLA4 CARMIL2 ITGB3 IL7R LIPA GATA6 HMBS SMAD4 EDNRB TTC7A SKIV2L JAK3 G6PC IL2RG CASP8 RFX6 RAG1 PINK1 CLMP IGLL1 HPS1 ITGA2B IL21 SPP1 TNFRSF13C JAK3 ABCB11 CD79A IL7R IL6 CDKN1A GALT BRCA1 EPCAM POLA1 CD19 CFHR3 CR2 STAT1 CD3D FOXP3 SPINT2 GDNF AIRE GUCY2C NHLRC2 AKR1D1 WAS MPI DCLRE1C IL2RA IKBKB KCNJ1 SGSH SP110 SAR1B MVK IKZF1 ATRX SAA1 SMAD4 STAR DAXX MRAP SLC12A3 BTK POLG MVK EDN3 CD109 OTULIN HNF4A SLC5A1 NCF4 COG4 RAG1 PIK3R1 SLC46A1 CDKN1B CHD7 SLC12A1 MGME1 HADH SMARCD2 B2M C1QA CD40LG BTK TMPRSS15 LRRK2 ZAP70 APC CD79B TTR ALG3 NR3C2 RECQL4 ITGA6 RAG2 SMAD4 IRAK1 RFXAP ACSF3 ELANE BMPR1A KCNJ11 IL2RG PALB2 SCN11A ACVRL1 ADA PIK3R1 MGME1 SCN9A MVK HMGCS2 CLCNKB CDKN1B SLC25A13 NEUROG3 RMRP RRM2B KIF23 ETHE1 DNMT3B PPP2R5D
Protein Mutations 1
R192G
SNP 0