Name (Synonyms) | Correlation | |
---|---|---|
drug3052 | zinc Wiki | 1.00 |
drug879 | Exebacase Wiki | 1.00 |
drug560 | Chloroquine Wiki | 0.35 |
drug1822 | Placebo Wiki | 0.06 |
Name (Synonyms) | Correlation | |
---|---|---|
D016470 | Bacteremia NIH | 1.00 |
D004696 | Endocarditis NIH | 1.00 |
Name (Synonyms) | Correlation |
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There is one clinical trial.
The purpose of this superiority study is to evaluate the efficacy and safety of exebacase in addition to standard of care antibiotics (SoCA) compared with SoCA alone for the treatment of patients with Staphylococcus aureus (S. aureus) bloodstream infections (BSI), including right-sided infective endocarditis (IE). Patients will be randomized to receive a single intravenous dose of exebacase or placebo. Patients will receive SoCA selected by the investigators based on the protocol. Exebacase, a direct lytic agent, is an entirely new treatment modality against S. aureus. Exebacase is a recombinantly-produced, purified cell wall hydrolase enzyme that results in rapid bacteriolysis, potent biofilm eradication, synergy with antibiotics, low propensity for resistance, and the potential to suppress antibiotic resistance when used together with antibiotics. Exebacase represents a first-in-field, first-in-class treatment with the potential to improve clinical outcome when used in addition to SoCA to treat S. aureus BSI including IE.
Description: TEAEs will be summarized by treatment group.
Measure: Treatment-emergent adverse events (TEAEs) through Day 60 Time: Through Day 60