Name (Synonyms) | Correlation | |
---|---|---|
drug1375 | Low Dose (10 mg) Control Wiki | 1.00 |
drug1726 | PB1046 Wiki | 1.00 |
drug269 | Azithromycin Tablets Wiki | 0.71 |
drug1103 | Hydroxychloroquine Sulfate Wiki | 0.28 |
Name (Synonyms) | Correlation | |
---|---|---|
D011654 | Pulmonary Edema NIH | 1.00 |
D000075902 | Clinical Deterioration NIH | 0.71 |
D011665 | Pulmonary Valve Insufficiency NIH | 0.41 |
D006333 | Heart Failure NIH | 0.38 |
D007249 | Inflammation NIH | 0.20 |
D013577 | Syndrome NIH | 0.11 |
D055371 | Acute Lung Injury NIH | 0.10 |
D012127 | Respiratory Distress Syndrome, Newborn NIH | 0.10 |
D012128 | Respiratory Distress Syndrome, Adult NIH | 0.09 |
D011014 | Pneumonia NIH | 0.06 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0010444 | Pulmonary insufficiency HPO | 0.41 |
HP:0001635 | Congestive heart failure HPO | 0.38 |
HP:0002090 | Pneumonia HPO | 0.06 |
There is one clinical trial.
This is a multicenter, randomized, double-blind, parallel group study to investigate the efficacy of PB1046 by improving the clinical outcomes and increasing days alive and free of respiratory failure in hospitalized COVID-19 patients at high risk for rapid clinical deterioration, acute respiratory distress syndrome (ARDS) and death. The study will enroll approximately 210 hospitalized COVID-19 patients who require urgent decision-making and treatment at approximately 20 centers in the United States.
Description: PaO2:FiO2 ratio is the ratio of partial pressure of arterial oxygen to percentage of inspired oxygen
Measure: Development of ARDS (PaO2:FiO2 ratio < 300 mm Hg) during hospitalization Time: Any time point between injection initiation and Day 28Description: Composite of: Total hospital days, Total ICU days, Total days of ventilator use, Total days of ECMO, Total days of invasive hemodynamic monitoring, Total days of mechanical circulatory support, Total days of inotropic or vasopressor therapy
Measure: Reduction in hospital resource utilization defined as a composite of:total days: in hospital, in ICU, on ventilator, on ECMO, with invasive hemodynamic monitoring, with mechanical circulatory support, and with inotropic or vasopressor therapy Time: 28 days