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HP:0002014: DiarrheaHPO

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug2641 SivoMixx (200 billion) Wiki 0.71
drug3287 hydroxychloroquine Wiki 0.50
drug313 Azithromycin Wiki 0.17

Correlated MeSH Terms (2)


Name (Synonyms) Correlation
D003967 Diarrhea NIH 1.00
D011014 Pneumonia NIH 0.06

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0002090 Pneumonia HPO 0.06

There is one clinical trial.

Clinical Trials


1 Evaluation of the Impact of Bacteriotherapy in the Treatment of COVID-19

In light of its high morbidity and mortality, COronaVIrus Disease 19 (COVID-19) pandemic spread is considered an unprecedented global health challenge. Given the very limited therapeutic options available against Severe Acute Respiratory Syndrome - CoronaVirus-2 (SARS-CoV-2) epidemic at this time, the evaluation of new resources, designed in the first instance for other pathologies but potentially active against COVID-19, represents a priority in clinical research. This is an observational, retrospective, non-profit study on the adjuvant use of bacteriotherapy in the early control of disease progression in patients affected by COVID-19 and treated with the current standard of care on the basis of the interim guidelines of the Italian Society of Infectious and Tropical Diseases. The main purpose of the study is to evaluate the effectiveness of bacteriotherapy in reducing the clinical impact of acute diarrhea, containing the progression of COVID-19 and preventing the need for hospitalization in intensive care units.

NCT04368351 COVID Pneumonia Diarrhea Dietary Supplement: SivoMixx (200 billion) Drug: Azithromycin Drug: hydroxychloroquine
MeSH:Pneumonia Diarrhea
HPO:Diarrhea Pneumonia

Primary Outcomes

Description: Comparison between the two groups. Acute diarrhea was defined as a stool with increased water content, volume, or frequency that lasts less than 14 days.

Measure: delta of time of disappearance of acute diarrhea

Time: 21 days

Secondary Outcomes

Description: Comparison between the two groups

Measure: Delta in the number of patients requiring orotracheal intubation despite treatment

Time: 21 days

Description: Comparison between the two groups

Measure: Delta of crude mortality

Time: 21 days

Description: Comparison between the two groups

Measure: Delta of length of stay for patients in hospital

Time: 21 days


HPO Nodes


HP:0002014: Diarrhea
Genes 377
ALAD CCDC47 CBL KCNJ1 TTR RAG1 SCN11A SLC46A1 ELP1 NEUROG3 BLNK CPOX SGSH SLC25A13 MVK IKBKB CD79A MPI POLG CD19 TRNF ATRX SLC39A4 RIPK1 LCT IGHM CLMP CD79B SYNJ1 TTC7A UCHL1 SDHD SAMD9 PTEN ZAP70 RAG2 PKP1 SERPING1 CDKN1B TYMP PIGT TTC37 CYP11B2 SCNN1B ADAM17 PHKB WNT2B NEUROG3 SNCA SAA1 HADH BTK HYOU1 GNS DBH SERPING1 LRBA ND1 ND4 TTC7A RRM2B COG4 ALDOB SCNN1A CD40LG SMARCD2 STX3 ABCB11 CFH ACVRL1 TSHR NCF4 NAXD AKR1D1 PODXL SLC5A1 POLG PALLD HLA-B TRNQ CDKN2A RUNX1 EDN3 RAG1 MPV17 NOD2 CTLA4 F5 SLC7A7 JAK3 TCN2 MEN1 IL21 ICOS MYO5B ITGA2 MRAP RFXAP TTC37 LIG4 HSD3B7 LRRK2 SUGCT MYD88 B2M GINS1 IL7R PALB2 ITGA2B ANTXR2 NAGLU OTULIN KIF1B KCNJ11 IL21R KRAS COX3 SP110 CYP27A1 SMAD4 AGA GP1BB NHLRC2 TNFRSF1A DAXX HGSNAT ABCC8 MLYCD IKZF1 DGAT1 VPS13C PTPRC ZAP70 RAG2 SCN9A TFRC OPLAH GLA SLC39A4 CARMIL2 EGFR ADA ABCB4 RAG1 SLC9A3 PARK7 HTRA2 CYP7B1 TRNS2 SI ITCH AK2 IL2RG DCLRE1C ASXL1 IGHM SERPING1 SPP1 TREH TXNRD2 SEMA3D RFXAP FBP1 ERCC2 SLC46A1 LRRC8A TLK2 SMAD4 CDKN1A DCLRE1C TRNS1 ATP8B1 SLC25A13 ACAT1 PMM2 EFL1 GDNF C5 ADA SLC12A3 MVK ICOS CDKN2C TRNH NAGS DDC CD247 GFI1 BMPR1A ACSF3 STAR RFXANK GALT ITGB4 FOXP3 CD79A PINK1 ETHE1 NLRC4 CD3D PLEC PIK3R1 ENG ELANE WIPF1 IL2RG TTR CPT1A SRP54 LIG4 BMPR1A TMPRSS15 HNF1A SAR1B CD247 GUCY2C STAT1 PPP2R5D MVK EDNRB ALG3 TET2 KIF23 RAG2 WAS SLC10A2 TGFB1 CD3E SPINT2 MC2R EPCAM DNASE1L3 RNF113A CLCNKB ITGA6 IFNGR1 COG6 CIITA STAT4 WAS AIRE RNF168 GP1BA RMRP SKIV2L BMPR1A G6PC SKIV2L RFX5 TNFRSF13C MGME1 TSHR DNMT3B DMPK PPP2R5D UCP2 BRCA1 APC NNT HNF4A TP53 TKFC ACSF3 HEXB COX1 ENG NSUN2 JAK3 CFHR1 TRNW IDS TYMP ND5 ANTXR2 CD79B ACADM CHD7 MYO5B ATP7A IGLL1 IRAK1 PCSK1 TNFRSF13B HPS1 PRKN HMGCS2 ND6 TCIRG1 IL7R SRSF2 CR2 CYP27A1 IL2RG BRCA2 IL2RB IL10RA PLVAP HMGCL BMPR1A RET GREM1 RAG2 ITGB3 TERT MEFV ECE1 AVP FOXP3 GATA6 SMAD4 NR3C2 HMBS NOD2 RECQL4 BTK RFXANK SEMA3C DES AP1S1 CDKN1B SLC12A1 IL6ST RFX6 RET RECQL4 TCF3 DCLRE1C USP7 MCM6 PIK3R1 CIITA ARX CR2 COG4 LIPA COX2 BLM NRTN SLC26A3 IGKC IL2RA LCK ETHE1 ACTG2 CD3D SLC7A7 NBN MEN1 CASP8 ADA IL7R SCNN1G MGME1 CD109 MAOA BTK BLNK CD55 IL6 IDUA SAR1B NBN SMAD4 ALG8 BTD RFX5 SLC19A2 SON CDKN2B TRNL1 STAT1 POLA1 RAG1 CFHR3 LIPA ASAH1 DNAJC6
Protein Mutations 1
R192G
SNP 0