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HP:0003202: Skeletal muscle atrophyHPO

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug2621 Sham intervention Wiki 1.00
drug1217 HIT-exercise Wiki 1.00
drug583 CT-Scan Wiki 0.71

Correlated MeSH Terms (2)


Name (Synonyms) Correlation
D009133 Muscular Atrophy NIH 1.00
D001284 Atrophy NIH 1.00

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 Effects of Three Months of COVID-19 Lockdown Induced Deconditioning After 13 Months of High Intensity Exercise Training in Early Postmenopausal Women

While "conditioning" by exercise training has been widely evaluated, the available literature on "passive deconditioning" (i.e. forced deconditioning) is predominately limited to studies with or with almost complete mechanical and/or metabolic immobilization/sedation of the respective functional system (e.g. paralysis, bedriddenness). Vice versa, the effects of moderately long interruptions of dedicated types of exercise while maintaining everyday activity are rarely addressed. However, this topic is of high relevance, e.g. considering that breaks of health-related exercise programs due to increased family/occupational stress, vacation or temporary orthopedic limitation are rather frequent in everyday life. In the present project we aimed to determine the effects of 3 months of physical deconditioning due to COVID-19 induced lockdown after 13 month of high intensity endurance and resistance exercise in early postmenopausal women on parameters related to health and physical fitness.

NCT04420806 Exercise Detraining Muscle Weakness Muscle Atrophy Other: HIT-exercise Other: Sham intervention
MeSH:Muscle Weakness Muscular Atrophy Atrophy
HPO:Skeletal muscle atrophy

Primary Outcomes

Description: Body composition as determined by Dual-Energy x-Ray Absorptiometry

Measure: Body composition

Time: From intervention end to 3 months FU

Secondary Outcomes

Description: Hip-/Leg extension strength as determined by an isokinetic leg press

Measure: Hip-/Leg extension strength

Time: From intervention end to 3 months FU

Description: cardio-metabolic risk factors summarized in the Metabolic Syndrome Z-Score according to the definition of the International Diabetes Federation

Measure: Metabolic Syndrome

Time: From intervention end to 3 months FU

Description: BMD at the lumbar spine and total hip as determined by Dual Energy x-Ray Absorptiometry

Measure: Bone Mineral Density (BMD)

Time: From intervention end to 3 months FU

Description: Menopausal symptoms as determined by the "Menopausal Rating Scale" (MRS) with a scale from 0 (no complaints) to 4 (very serious complaints).

Measure: Menopausal symptoms

Time: From intervention end to 3 months FU

Description: Back and joint pain as determined by a standardized pain questionnaire with a scale from 0 (never) to 7 (permanent) for pain frequency or 0 (no pain) to 7 (extremely) for pain severity.

Measure: Back and joint pain

Time: From intervention end to 3 months FU


HPO Nodes


HP:0003202: Skeletal muscle atrophy
Genes 735
PFN1 GLE1 SGCD MTAP INSR NEB FRG1 PMP22 ERLIN1 NARS2 PLEKHG5 LMNA TIA1 CRPPA KLHL9 NEFL COG7 PMP22 PNPLA6 PEX7 LARGE1 MAG LRSAM1 CD59 OGDH PON1 SACS ERGIC1 TPI1 TDP1 GBE1 ADSL GPR35 WASHC5 TK2 EGR2 PRPH SYNE2 PPARGC1A BICD2 LIMS2 MPZ C19ORF12 DNA2 TRPV4 ATP8 PMP22 TPM2 GFPT1 HSPB3 VAPB AIFM1 RYR1 AK9 LMNA SLC5A7 VPS13A KIF1A TRIM32 HMGA2 TNNT1 COLQ POLG TCF4 SDHB COL6A2 SLC33A1 SLC7A7 COQ2 TTPA NDUFAF6 ATXN3 NEK1 PNPLA6 SYNE1 KDM5C SCN4A POLG TBCD PIEZO2 HK1 HSPB1 OPTN COL13A1 MYMK COL6A1 ZC4H2 REEP1 PHYH SFXN4 MYH7 HNRNPA1 AGL NDUFA12 WRN C9ORF72 UNC13A SELENON CHRNG DYSF ALDH18A1 GYG1 CHRNE COL6A3 BBS4 CAPN3 PDE8B NALCN DYSF ANTXR2 TPM2 COL6A1 LRP12 PSMB8 VRK1 PNPLA6 PRUNE1 PRKAR1A CRPPA SQSTM1 MME KIF5A MST1 TRAPPC11 SELENON ATXN1 IGHMBP2 APTX DYNC1H1 RYR1 DMD RAI1 LAMP2 PHGDH SLC18A3 COA7 SLC25A4 TRPV4 COL13A1 ERBB4 UBQLN2 KY TOE1 SQSTM1 ABHD12 MTMR2 TRAPPC11 CNTNAP1 LDB3 SALL4 PLEC LEMD3 BMP1 DGUOK ADSS1 FAM126A FARS2 PFN1 ATAD3A JPH1 PNKP LMNA GNE HNRNPDL MYH14 TIA1 GNAS ACTB SPTBN4 COL6A3 SDHD ZFYVE26 NUP88 HNRNPA2B1 DYSF TBC1D23 MYH3 C9ORF72 CCNF HSPB1 REEP1 ALS2 TARDBP SGCB DARS2 MYO9A MED25 TFG SEPTIN9 PIP5K1C SLC52A2 INPP5K SDHAF1 TTC19 C12ORF65 SIL1 AGRN SPG11 ACTA1 TK2 SNAP25 BBS10 SLC39A13 BSCL2 BICD2 DCTN1 AIFM1 RNASEH1 DNMT3B KIF1A TMEM43 BVES NEB BBS9 TREM2 SLC25A19 ATXN2 VAPB CHMP2B CHRNB1 PHF6 PYGM SCN4A BBS2 SQSTM1 FKTN PEX5 KLC2 CRPPA DOK7 SIL1 CHRNE ZFYVE26 C19ORF12 SYNE1 NEFH COL12A1 SOD1 INF2 MAFB STIM1 SUCLG1 MTM1 LZTFL1 NOP56 NEU1 MGME1 USP8 DMPK RBM28 FIG4 VCP SOD1 TARDBP RXYLT1 CEP126 DES TYMP NDRG1 LMNA COL6A1 SMCHD1 SLC25A1 ARSI RBM28 ACADM LRP4 TIA1 LMNA CCDC115 WDR81 CAPN3 RRM2B GARS1 PEX10 FLNC NAGA KCNK9 FKRP ATP8A2 ATP7A ERLIN2 FKBP14 MKKS CHMP2B FKTN SPART GLE1 CFAP410 HINT1 PNKP POMT1 SELENON LTBP4 MPZ AIP TGFB1 SLC18A3 CCT5 PYCR2 CHRND SMN1 TTN SBF2 B4GAT1 SOX10 CPT1A SLC52A3 PRKACA HUWE1 SIGMAR1 AP1S2 AMPD2 AR ARL6 ASCC1 LEMD3 MYH7 NIPA1 TNXB TTN MME ANO5 NGLY1 ATL1 ALDH18A1 SLC5A7 ACTA1 CTNS MPZ MGME1 VCP FBLN5 MECP2 TTN EPHA4 PYCR2 GJB1 NBN SYT2 GJB1 LAMB2 ERBB3 DNM1L RTN2 ASAH1 FBXO38 SLC25A21 POLR3A CHRNA1 ANO5 TNFRSF1B ASAH1 OPA1 NUP88 DCTN1 AIFM1 TTC8 TRIM32 ERLIN1 HNRNPA2B1 TRIP4 CAPN3 SH3TC2 NEFH CHCHD10 PNKP VAMP1 HNRNPA1 COL6A2 AARS1 TTN DAO TRPV4 ATXN3 SURF1 DHTKD1 DMD GDAP1 MYMK SPRTN SMN1 SMN2 TRAPPC11 COL6A2 FHL1 BSCL2 C19ORF12 RPS6KA3 EGR2 HINT1 PON2 SCN9A SGCA REEP1 ERLIN2 YARS2 SMN1 VPS13D ABCA1 CHRNB1 FUS MYOT BSCL2 INSR COG8 PMP22 BBS5 HNRNPA1 CAV3 B4GALNT1 POMGNT2 MSTO1 HSPG2 TBCK MYPN NEB PUS1 MFN2 TPM3 SPG11 SLC9A6 KLHL41 DCAF8 FKBP14 WARS2 SMCHD1 ALDH18A1 FUS LMOD3 ATXN3 SPEG SYNE2 COL12A1 GLE1 TTN GARS1 PHKA1 DNM2 VMA21 MATR3 NAGA RAB7A PNPT1 VAMP1 PON3 SGCD MFN2 AGTPBP1 MDH2 RAPSN COASY SUCLA2 MKS1 SLC12A6 TCAP SQSTM1 YY1 RYR1 NEB ACTA1 MYOT CA8 MUSK CAPN1 GLT8D1 AFG3L2 ALS2 RNASEH1 PEX6 FXN POMGNT1 MYH7 TPI1 COL6A2 DAG1 NEU1 GNE SLC39A13 CYP7B1 DCTN1 MORC2 GAN PLEC MAP3K20 PNPLA2 ANXA11 CCT5 BIN1 TRPV4 RYR1 ACTA1 MFN2 CRPPA FLNA DOK7 CHN1 EXOSC3 GBA2 DGUOK GARS1 NDUFS4 TAF15 RYR1 FLNC CAPN1 CTLA4 GJB1 AP1S2 BICD2 ATL1 ATXN2 ATXN3 KIF1C ACTA1 GDAP1 WDPCP SLC46A1 SCO2 PFKM PLOD3 FARS2 POMT1 REV3L CHRNA1 PRPS1 MPZ BBS12 FKRP CEP290 MYOT FAM111B RAPSN CPT1C ENTPD1 LMNA ADSS1 REEP1 BSCL2 PDK3 PMP22 CUL4B SLC16A2 MATR3 ANO5 RRM2B TUBB2B MPZ NEFL MPZ PLXND1 B4GALNT1 YARS2 IFT27 SDHA FGD4 HARS1 KLHL41 SDCCAG8 EMD KLC2 TARDBP VCP PTEN TBK1 TBK1 PNPLA6 PIK3R2 CHCHD10 KBTBD13 MUSK TPM3 PGAP1 FKRP TK2 DARS2 AMPD2 ERGIC1 ACADSB ZBTB20 COL6A2 PRX ATM SLC33A1 COL4A1 RETREG1 VCP MYH7 CHRNB1 LMOD3 BBS7 MPZ COL6A3 MPV17 NEFH TBCE TPM2 STAC3 SLC52A2 FIG4 TBK1 KLHL40 WNK1 MYPN YARS1 SCYL1 DOK7 VPS13A CHRNE ASAH1 KY PRPH ATAD3A KIF1C VLDLR TPM3 DUX4 FRG1 MPZ EGR2 MPZ HEXB SPART IBA57 DYSF SETX TRNL1 C9ORF72 CHCHD10 NOP56 BIN1 BBS1 DHH ITGA7 LMNA CD28 GMPPB TBCE COL2A1 CHRND POMK GFPT1 MECP2 CHP1 MYOD1 CPLANE1 SPAST PHKG2 COL6A1 FUS TMEM43 TNNT1 PDE11A MYBPC1 GDAP1 SACS COL6A3 NDUFA9 FBXL4 LITAF KIF1B SGCG ANG DNAJC19 KIF1A OPA1 POMT1 CHAT VAPB DAG1 FLRT1 FHL1 ACTA1 C8ORF37 NPHP1 ATL1 ANG VCP SYT2 PMP22 POMT2 ADK TBCD SETX SQSTM1 GDAP1 VCP AFG3L2 TRNE SMN1 POLG PUS1 IFRD1 STUB1 PHKA2 FKTN BBIP1 PRX MUSK B3GALNT2 HSPB8 POMT2 TNXB VCP TFG PYROXD1 ATXN1 C12ORF65 PLP1 PSAT1 GLE1 IFT172 FLVCR1 STAC3 ZC4H2 C12ORF65 TDP1 HSPG2 TPM3 MRE11 EXOSC8 GLB1 MCCC2 NDE1 DNAJB2 CPT1C KLHL41 TGFB1 GDAP1 UBA1 AGRN B4GALT7 BAG3 SLC16A2 LMNB2
Protein Mutations 1
G71R
SNP 0