Name (Synonyms) | Correlation | |
---|---|---|
drug579 | CPI-006 Wiki | 0.71 |
drug1739 | Metformin XR Wiki | 0.71 |
drug580 | CRI management Wiki | 0.71 |
drug1374 | Icosapent ethyl Wiki | 0.50 |
drug2122 | Placebo Wiki | 0.04 |
Name (Synonyms) | Correlation | |
---|---|---|
D050197 | Atherosclerosis NIH | 1.00 |
D011236 | Prediabetic State NIH | 0.50 |
D012141 | Respiratory Tract Infections NIH | 0.14 |
D002318 | Cardiovascular Diseases NIH | 0.13 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0011947 | Respiratory tract infection HPO | 0.14 |
HP:0001626 | Abnormality of the cardiovascular system HPO | 0.13 |
There are 2 clinical trials
This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in patients who have pre-diabetes and heart or blood vessel problems.
Description: The primary outcome measure is the time to first occurrence of death, non-fatal myocardial infarction or stroke, hospitalization for unstable angina with objective evidence of acute myocardial ischemia, or coronary revascularization driven by acute or progressive symptoms.
Measure: Time in days to death, non-fatal myocardial infarction, stroke, hospitalization for unstable angina, or symptom-driven coronary revascularization Time: through study completion, an average of 4.5 yearsDescription: Time to first occurrence of death, myocardial infarction, or stroke Time to first occurrence of a primary endpoint event, peripheral arterial disease event, or hospitalization for congestive heart failure Cumulative incidence of all components of the primary endpoint, including recurrent or multiple events in the same participant Cumulative incidence and time to first occurrence of each component of the primary outcome measure, peripheral arterial disease events, and hospitalization for congestive heart failure
Measure: Time in days to Cardiovascular Outcomes Time: through study completion, an average of 4.5 yearsDescription: Time to new or recurrent diagnosis of a malignancy or death from a malignancy
Measure: Time in days to Oncologic Outcome Time: through study completion, an average of 4.5 yearsDescription: Time to new diagnosis of type 2 diabetes (ADA criteria)
Measure: Time in days to Diabetes Outcome Time: through study completion, an average of 4.5 yearsMITIGATE COVID-19 is a prospective, open-label, parallel-group, randomized, pragmatic clinical trial. The MITIGATE COVID-19 Study has been designed to evaluate the real-world clinical effectiveness of pre-treatment with icosapent ethyl (IPE), also known as Vascepa®, compared to usual standard of care to prevent and reduce the sequelae of laboratory-confirmed viral upper respiratory infection (URI)-related (i.e., COVID-19, influenza, and other known viral respiratory pathogens) morbidity and mortality in a high-risk cohort of adults with established atherosclerotic cardiovascular disease (ASCVD).
Description: Confirmed viral URIs (i.e., including recurrent events) (i.e., COVID-19, influenza, and other known viral respiratory pathogens) based on laboratory testing (i.e., FDA or locally-approved testing modalities) with an oxygen saturation <94% on room air and/or requiring any form of supplemental oxygen.
Measure: Percentage of patients with moderate or severe confirmed viral URIs Time: 0-12 monthsDescription: At any point in time based on a 7-point ordinal scale (i.e., 1 = death, 2 = mechanically ventilated/extracorporeal membrane oxygenation, 3 = high flow supplemental oxygen, 4 = low flow supplemental oxygen, 5 = hospitalized with no supplemental oxygen requirements, 6 = urgent care or emergency department visit not leading to hospitalization, and 7 = no relevant clinical encounters)
Measure: Worst clinical status due to a confirmed viral URI Time: 0-12 monthsDescription: Death due to any cause, hospitalization for myocardial infarction, or hospitalization for ischemic stroke
Measure: Percentage of participants experiencing a major adverse cardiovascular event Time: 0-12 monthsDescription: Major adverse cardiovascular events, hospitalization for acute coronary syndrome, and coronary revascularization (i.e., percutaneous coronary intervention and/or coronary artery bypass graft)
Measure: Percentage of participants experiencing an expanded major adverse cardiovascular event Time: 0-12 months