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drug1329 | Susceptibility to infection Wiki | 0.71 |
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D020022 | Genetic Predisposition to Disease NIH | 0.71 |
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There are 2 clinical trials
Background: There is a current worldwide outbreak of the novel coronavirus Covid-19 which originated from Wuhan in China and has now spread to 6 continents including 210 countries. There is still a lack of any report about severe acute respiratory syndromes (SARS-CoV-2) genetic polymorphisms which are associated with the susceptibility to infection. In addition, gene polymorphisms of MBL (mannose-binding lectin) associated with antigen presentation are related to the risk of SARS-CoV infection. Aim: To investigate the association of different genetic markers of different mechanisms of viral pathogenesis with the outcome of COVID-19. Methods: The study will include one hundred patients diagnosed as COVID-19. Biological blood samples will be taken for routine diagnostic analysis, routine molecular testing using Real-time polymerase chain reaction (PCR), Allelic discrimination and genotyping analysis. Outcome: Different genetic markers could play a role in the outcome and prognosis of COVID-19 viral infection.
Description: To assess genetic mutation via detection of genetic polymorphisms of ACE2 in patients and control to detect what alleles will be associated with the susceptibility to COVID-19 and what alleles will be associated with clearance or protection from infections. using allelic discrimination SSCP (i.e Real-time PCR and genetic sequencer).
Measure: for the patients Time: 2 yearsThe primary objective of this study is to establish differences in susceptibility to SARS CoV-2 infection among health care workers (HCW) highly exposed to patients with COVID-19 diagnosis. To ascertain this issue, we evaluated: - Changes in receptor polymorphism (ACE2 and CD26 receptor study. - SARS-CoV-2 CD4/CD8 T cell response (CTL) - Different KIR phenotypes
Description: ACE2 analysis
Measure: Susceptibility to SARS CoV-2 infection according to ACE2 receptor Time: 1 monthDescription: Activation of CD4-CD8 by viral peptides
Measure: Cellular immune response to SARS CoV-2 infection Time: 1 monthDescription: Analysis of KIR in NK cells
Measure: Susceptibility to infections according to KIR phenoytpes Time: 2 monthsDescription: Survey
Measure: Characteristics of exposure in time and intensity of HCW with SARS CoV-2 infection Time: 1 monthDescription: Activation of CD4-CD8 by viral peptides
Measure: Cellular immune response in HCW with positive IgG against SARS CoV-2 Time: 1 month