CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Report for D004198: Disease Susceptibility NIH

(Synonyms: Disease Susceptibility)

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)


Name (Synonyms) Correlation
drug1329 Susceptibility to infection Wiki 0.71

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D020022 Genetic Predisposition to Disease NIH 0.71

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There are 2 clinical trials

Clinical Trials


1 Various Molecular Markers With Predictive and Prognostic Significance in COVID-19 Outcome

Background: There is a current worldwide outbreak of the novel coronavirus Covid-19 which originated from Wuhan in China and has now spread to 6 continents including 210 countries. There is still a lack of any report about severe acute respiratory syndromes (SARS-CoV-2) genetic polymorphisms which are associated with the susceptibility to infection. In addition, gene polymorphisms of MBL (mannose-binding lectin) associated with antigen presentation are related to the risk of SARS-CoV infection. Aim: To investigate the association of different genetic markers of different mechanisms of viral pathogenesis with the outcome of COVID-19. Methods: The study will include one hundred patients diagnosed as COVID-19. Biological blood samples will be taken for routine diagnostic analysis, routine molecular testing using Real-time polymerase chain reaction (PCR), Allelic discrimination and genotyping analysis. Outcome: Different genetic markers could play a role in the outcome and prognosis of COVID-19 viral infection.

NCT04390269 Genetic Predisposition to Disease
MeSH:Disease Susceptibility Genetic Predisposition to Disease

Primary Outcomes

Description: To assess genetic mutation via detection of genetic polymorphisms of ACE2 in patients and control to detect what alleles will be associated with the susceptibility to COVID-19 and what alleles will be associated with clearance or protection from infections. using allelic discrimination SSCP (i.e Real-time PCR and genetic sequencer).

Measure: for the patients

Time: 2 years

2 Differences in Susceptibility to SARS CoV-2 Infection According to ACE2 and CD26 Receptors, Specific CD4/CD8 T Cell Response to Viral Peptides, and KIR Receptors Among Health Care Workers Highly Exposed to Patients With COVID-19 Diagnosis.

The primary objective of this study is to establish differences in susceptibility to SARS CoV-2 infection among health care workers (HCW) highly exposed to patients with COVID-19 diagnosis. To ascertain this issue, we evaluated: - Changes in receptor polymorphism (ACE2 and CD26 receptor study. - SARS-CoV-2 CD4/CD8 T cell response (CTL) - Different KIR phenotypes

NCT04402827 Health Care Worker Patient Transmission Receptor Site Alteration Susceptibility, Disease Immune Response Diagnostic Test: Susceptibility to infection
MeSH:Disease Susceptibility

Primary Outcomes

Description: ACE2 analysis

Measure: Susceptibility to SARS CoV-2 infection according to ACE2 receptor

Time: 1 month

Description: Activation of CD4-CD8 by viral peptides

Measure: Cellular immune response to SARS CoV-2 infection

Time: 1 month

Description: Analysis of KIR in NK cells

Measure: Susceptibility to infections according to KIR phenoytpes

Time: 2 months

Secondary Outcomes

Description: Survey

Measure: Characteristics of exposure in time and intensity of HCW with SARS CoV-2 infection

Time: 1 month

Description: Activation of CD4-CD8 by viral peptides

Measure: Cellular immune response in HCW with positive IgG against SARS CoV-2

Time: 1 month


HPO Nodes