Covid 19 Research using Clinical Trials (Home Page)
Report for D010146: Pain NIH
(Synonyms: Pain)
Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation
Correlated Drug Terms (7)
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug1611 | non interventional Wiki | 1.00 |
| drug953 | Other drugs Wiki | 1.00 |
| drug884 | Niclosamide Wiki | 0.71 |
| drug889 | Nitazoxanide Wiki | 0.50 |
| drug715 | Ivermectin Wiki | 0.35 |
| drug308 | Chloroquine Wiki | 0.35 |
| drug505 | Favipiravir Wiki | 0.30 |
Correlated MeSH Terms (2)
| Name (Synonyms) | Correlation | |
|---|---|---|
| D001416 | Back Pain NIH | 1.00 |
| D017116 | Low Back Pain NIH | 1.00 |
Correlated HPO Terms (0)
| Name (Synonyms) | Correlation |
|---|
There is one clinical trial.
Clinical Trials
1 Confinement Effect on Low Back Pain Intensity in Chronic Low Back Pain Patients
The current situation, linked to the pandemic of the new coronavirus SARS-CoV-2 generates health concerns, but is also accompanied by many other psychological, social, economic, professional, etc. consequences as well as numerous changes in behavior and lifestyles, notably due to confinement. While the prevention of chronic low back pain and its management are primarily based on the practice of regular physical and sports activity, other psychological factors (stress, anxiety, depression), socioeconomic (low level of education, resources), professionals (physical workload, job dissatisfaction), etc. also have a major role in the onset and the persitence of low back pain. Thus, it is to be supposed that the current context, and more particularly the confinement to which the population has been constrained for almost 2 months, have and will have notable consequences on the evolution of lumbar symptoms in chronic low back pain patients. However, the entanglement of different factors related to containment will potentially have different consequences depending on the individual. It therefore seems difficult to predict how the lumbar symptoms will develop in this population. Indeed, if it can imagined that the decrease in regular physical activity and the increase in anxiety in this context of insecurity could lead to an increase in pain, it could just as well consider that the decrease in stress work, strenuous physical work or travel time from work to home can, on the contrary, have a favorable effect. The objective of this study is to assess the confinement effect on low back pain intensity in chronic low back pain patients. This is an observational, descriptive, transversal and pluricentric study conducted by a single questionnaire.
NCT04406363 Chronic Low-back Pain Other: non interventional MeSH:Back Pain Low Back Pain Pain
HPO:Back pain Low back pain Pain
Primary Outcomes
Description: Proportion of subjects having a significant change in their low back pain intensity during confinement, defined by the items "much worse" and "moderately worse", or "much improved" and "moderately improved" respectively.The meaning of this significant change (worsening or improvement) will also be described.
Measure: Impact of confinement on the low back pain intensity Time: at inclusion
Secondary Outcomes
Description: Change in low back pain intensity between before and during confinement evaluated by a numerical pain scale rated from 0 to 10 (0 = no pain ; 10 = worst imaginable pain). Confinement conditions (alone or in a group, space, etc.) and the practice of physical and sporting activities during confinement (weekly duration, etc.)
Measure: Correlation between confinement conditions and low back pain intensity Time: at inclusion
Description: Disability measured by the "incapacity" sub-score of the "Core Outcome Measures Index" (COMI) questionnaire
Measure: Correlation between confinement conditions and disability related to low back pain Time: at inclusion
Description: Occurrence of a SARS-CoV-2 infection and its level of severity (confirmed diagnosis, few or no symptoms, symptoms severely limiting daily activities, hospitalization in a conventional service or in intensive care)
Measure: Correlation between infection with the new SARS-CoV-2 coronavirus and change in low back pain intensity Time: at inclusion
Description: Quality of life and levels of anxiety and depression evaluated with the COMI-AD sub-score (modified version of the COMI integrating the state of psychological health);
Measure: Correlation between confinement conditions and quality of life as well as psychological health Time: at inclusion
Description: Use of care, drug consumption and psychoactive substances (tobacco, cannabis, alcohol, anxiolytics) for low back pain
Measure: Impact of confinement on the use of care and the consumption of medication and psychoactive substances for low back pain Time: at inclusion
Description: Modalities of the the ocupational activity continuation (continuation of the activity, evolution of the working time, telework and modalities of establishment)
Measure: Correlation between working conditions and / or teleworking and low back pain intensity Time: at inclusion
Description: Experience of confinement. Socio-economic characteristics of the participants (age, sex, department, job and socio-professional category).
Measure: Correlation between socio-economic factors and modalities as well as the experience of confinement Time: at inclusion
HPO Nodes
HP:0012531: Pain
Genes 835
TREX1 PORCN TET2 IDH2 ERCC4 TGFB2 COL1A1 MLX TCF4 GPR101 TWNK RRM2B MC2R TRPS1 SCN4A NOD2 CAV3 CTRC TRNL1 EXT1 BCL10 MATN3 BSCL2 OTULIN PRKCD CR2 C11ORF95 PTPN3 LACC1 KY OPA3 CASK PPARGC1A MALT1 LMNA TMEM43 MYOT SCN1B ERAP1 RPS20 MME TCIRG1 FLI1 CFI BMPR1A TP53 DNASE1L3 SUFU RNU4ATAC FOXP1 TBX1 VCP ATP6 COL2A1 ND1 PGK1 CLCNKB HFE COX2 LOX CTRC UBQLN2 HABP2 CORIN GNPTG CD81 TNFSF12 LMNB2 ACADM FHL1 ANO5 RAD51 MATR3 GNE DKK1 PRNP ACTG2 EDNRB CDKN2B SPTB DNM2 ATXN3 MLH1 TMEM126B MEFV FIG4 COL9A2 NFKB1 CDKN1A HADHA CA2 ALAD TRNS1 MATN3 MPL F5 SERPINF2 STAT3 CYP2R1 CHEK2 POLG2 SEC24C TSC1 HNRNPA1 SYNE1 C1R MYH7 BVES GBA ANKH PHEX TET2 LDLRAP1 HLA-DRB1 MSMO1 SLCO2A1 DCC GNAS CFTR ZNF469 TNFSF11 RYR1 AGXT HLA-DPA1 LMNA SPTA1 TNFRSF11A LPL SDHB DIS3L2 PIGA COL5A2 TNFRSF1A BMP2 SNX10 NNT GUCY2C BCOR SFRP4 POMT1 WNT3A POLE DLEC1 PNPLA2 PIEZO1 PHKA1 MVK BRCA2 JAK2 VPS13A SDHD SEMA3D PTPN2 TREM2 SPG7 DNAL4 STIM1 TGFB3 PSMB4 HPS1 DMD JAK2 HMBS ABCA1 F12 NUMA1 DCTN1 TXNRD2 ND5 SMAD4 TAF15 CPT2 ACADVL EMD FKRP CNBP CAV1 ALAD MYC HADHB STAT5B GBA EXT2 PHEX RREB1 CCR6 MPL TRPA1 CRPPA FGF23 TRIM32 MMUT PRDM5 TGFB1 ABCC2 PPARG GP1BB VCP STING1 GPC3 NABP1 VDR NRTN PTPN2 PFN1 TBX18 PRTN3 MEFV FERMT3 RET SCN4A CASQ1 THPO SOD1 SLCO1B3 MIF TRNF LPIN2 CLCN5 NEK1 PIGT SCNN1A TRAPPC11 APOB UFSP2 PTEN STAT4 CRPPA STK11 CALR MLYCD LPIN2 CASR FKTN H19 CYP19A1 ABCG8 COPA HFE PRKAR1A GCGR BRCA1 USP8 KIF1B RELA DYSF PML SMAD4 VHL MFN2 LBR SRP54 TARDBP SPTA1 WWOX MYH11 TYROBP COL2A1 COL2A1 TRAPPC11 BIN1 RRM2B DDIT3 MEF2A PPOX SERPING1 GNAS MYH7 MITF CASR TRPS1 DNA2 STAT6 ACADL CYSLTR2 SMARCB1 NOD2 SDHC SERPING1 CLIP2 FSHR CAVIN1 PSMB9 ORAI1 GYPC CHST3 CFAP410 HLA-B NOTCH2 SCN4A TRAPPC2 HTRA1 POLG2 TRPM4 TMEM127 STAR ALDOB TNFRSF13C CAV1 BMPR1A UBAC2 POLG NLRP3 TSC2 CD247 RNASEH1 TRIP13 IL23R SCN11A PMS1 GNA11 PRSS1 FDX2 SCN4A HLA-B CLCN7 MSH6 POU6F2 NTN1 TGFB2 PIK3CA MYH11 LDLR RET VHL COMP COL2A1 MYL2 AMPD3 EPCAM MEN1 KRAS SDHAF2 RNASEH1 HBB MYLK IGH RB1 CYP2R1 MYF6 IL2RB SMAD4 ASPN TRNE SDHC HLA-B GTF2I EPB42 CTRC C1S TRNW FKRP DNA2 LMNA TREX1 BTNL2 NEFH TRNH OPA1 DAO CPOX VANGL1 NLRC4 GPR35 TBX1 TNNC1 ERLIN1 CCDC78 LMNA ANKRD55 TP53 CLCN1 ACTA2 FLVCR1 SEMA3C FMR1 NLRP3 CHCHD10 TCIRG1 PLN SCN4A FAN1 DSE CDC73 IRF5 FAS COL11A1 HNRNPA1 TRAPPC2 PALLD PLCG2 HPGD TRNE RNF168 PON2 MLH3 GNAQ CLCN7 CPT2 VCP NLRC4 PRSS1 DMD SLC40A1 G6PD MEFV PDGFRA DKK1 LMNA SLC40A1 WT1 BAP1 CYP27B1 HEXB COL17A1 IL2RA OPTN SCARB2 BSCL2 SPINK1 IL6 SOX10 MYH7 IL12A WT1 STOX1 SLC25A4 FMR1 SDHD IRAK1 DAXX MST1 MSTO1 TRNL1 PSMB8 HOGA1 IL12A-AS1 HADHA SQSTM1 TNFSF12 GNAS GNAS DOLK APC TRIM28 ESR1 NLRP3 CTSK PTPN22 NAB2 DPM3 TGFBR2 EDN3 MVK ANK1 TYMP KRAS TNFRSF11A PALB2 SEMA4A TEK UFD1 FUS MCM6 COL11A2 HNRNPA2B1 HGD CASQ1 RET FOS SOX10 BRCA2 RBCK1 F8 HELLPAR SQSTM1 NFKB2 FBN1 TRNQ JMJD1C SLC25A26 AMPD1 CD46 PMP22 GNAS POMP ICOS CEL IL2RA SDHD HLA-DRB1 TP53 EWSR1 CHMP2B INHBA CAT SLC34A3 DMP1 COL11A2 ADA2 EPB41 GFI1 CFTR DYSF SYNE2 SLC25A4 ATXN2 LRP5 MET GLA ABCG8 FOXE1 SLC25A11 COL9A3 BIRC3 FKRP IRF2BP2 PPOX GDNF TCIRG1 STAT4 CTNNB1 CDKN1B GLA VCP MAFB STK11 IL1RN LEMD3 SF3B1 FLT1 COMT SLC26A2 MVK HADHB WAS NLRP12 TREH TGFBR2 POLG MMP2 SLC4A1 TNFRSF1A CARS2 VCP ANO5 COX1 COMP EXT1 REST ZBTB16 GNAS ND4 COL2A1 KCNN4 SDHD OPLAH XPA FSHR CDKN1B PRKRA CPA1 HMBS PTPN22 HPGD C1QA ELN PON1 ERCC5 PYGM TGFB1 MFN2 BMPR1A FLNC XPC LMX1B CAPN3 AP2S1 PDGFB FUS ANKRD55 CCN2 ELANE MEFV CCR1 MTMR14 SCN9A PRPH COL9A1 CD19 IL2RB CLCN1 TREM2 GHSR PTPN22 RFC2 SMAD3 WIPF1 MME CFTR CYP27B1 CDKN2A LMNA HPGD SPINK1 FGF23 POMT1 ND6 CTLA4 RARA CDKN2C C9ORF72 ALDH18A1 NKX2-5 HLA-B NLRC4 BRCA1 GLT8D1 VDR GNA11 SCNN1B ANG GLE1 EPAS1 PNPLA2 NLRP3 SPINK1 HLA-DRB1 PRKCD IDH1 NGLY1 FOXE3 MFN2 KLRC4 LMNA NPM1 REEP2 MYBPC3 KIF1B SLC34A3 ELN SCN5A COL2A1 ACADVL TK2 AGPAT2 LPIN1 SLC12A3 HBB POLG CHST6 PIGY SH2B3 LIMK1 MRAP NLRP3 SERPING1 FIP1L1 TBL2 CLDN16 CPOX PTH1R SPTB TWNK TBL1XR1 ENPP1 MDH2 SLCO1B1 DNM1L SCN4A IDH2 GNA14 STX16 ACAD9 ATP7B SCNN1G MPL SLCO2A1 RYR1 CLCN7 JAK2 WT1 HIRA SLC40A1 PRKCSH FHL1 TP53 MYH3 ELANE CAV3 DGUOK UNC13A TBK1 EDN3 SEC63 ERCC3 PRKRA HGD CLCN5 PTH1R RNF6 HLA-DPB1 MATR3 VAPB DLST ERCC2 STIM1 HSPG2 DBH SLC26A2 CCNF LDHA C4A TNFRSF13B COQ7 TRAPPC11 CALR MINPP1 PTPN22 SPINK1 TRNK WNT1 VCP NLRC4 TET2 ERBB4 MFAP5 MSTO1 EPOR SLC4A1 MAT2A ATRX PRKCSH TMEM43 SLC12A3 POLG CD55 PRDM5 SDHB PRKAR1A DDB2 TLR4 SLC39A14 CDH23 HARS1 SAA1 COL9A1 IL10 CD247 PRSS1 TNXB PMS2 SEPTIN9 GBA HBB AIP TBX6 CHST3 COMP TRIM28 TP53 STAT4 PSMB8 CDC73 ARVCF ZNF687 COX3 POLR3A PTPN11 KIT TYMP COL5A1 STIM1 ASAH1 FH IKZF1 HFE NOD2 MS4A1 TRPV4 PON3 PLEKHM1 BAP1 TNXB TRNS2 SPAST SCN9A COL11A2 ALDOB NLRP3 EDNRB PGAM2 PRKG1 PRSS2 CAVIN1 TGFBR1 DLL3 PPARG RRM2B BAZ1B IL12B MAX TGFBR2 IDH1 STAT4 PSTPIP1 SPP1 ENO3 CTNNB1 CCND1 EPHA4 CAV3 JAK2 SDHB MSH2 ECE1 APC PRSS2 TRNW JAK2 RET SDHA PCSK9 CFH MESP2 FTL ANXA11 NF2 IL6 TET2 ABCG5 MPL GTF2IRD1 SCN4A TRNK Protein Mutations 0
SNP 0
Primary Outcomes
Description: Proportion of subjects having a significant change in their low back pain intensity during confinement, defined by the items "much worse" and "moderately worse", or "much improved" and "moderately improved" respectively.The meaning of this significant change (worsening or improvement) will also be described.
Measure: Impact of confinement on the low back pain intensity Time: at inclusionSecondary Outcomes
Description: Change in low back pain intensity between before and during confinement evaluated by a numerical pain scale rated from 0 to 10 (0 = no pain ; 10 = worst imaginable pain). Confinement conditions (alone or in a group, space, etc.) and the practice of physical and sporting activities during confinement (weekly duration, etc.)
Measure: Correlation between confinement conditions and low back pain intensity Time: at inclusionDescription: Disability measured by the "incapacity" sub-score of the "Core Outcome Measures Index" (COMI) questionnaire
Measure: Correlation between confinement conditions and disability related to low back pain Time: at inclusionDescription: Occurrence of a SARS-CoV-2 infection and its level of severity (confirmed diagnosis, few or no symptoms, symptoms severely limiting daily activities, hospitalization in a conventional service or in intensive care)
Measure: Correlation between infection with the new SARS-CoV-2 coronavirus and change in low back pain intensity Time: at inclusionDescription: Quality of life and levels of anxiety and depression evaluated with the COMI-AD sub-score (modified version of the COMI integrating the state of psychological health);
Measure: Correlation between confinement conditions and quality of life as well as psychological health Time: at inclusionDescription: Use of care, drug consumption and psychoactive substances (tobacco, cannabis, alcohol, anxiolytics) for low back pain
Measure: Impact of confinement on the use of care and the consumption of medication and psychoactive substances for low back pain Time: at inclusionDescription: Modalities of the the ocupational activity continuation (continuation of the activity, evolution of the working time, telework and modalities of establishment)
Measure: Correlation between working conditions and / or teleworking and low back pain intensity Time: at inclusionDescription: Experience of confinement. Socio-economic characteristics of the participants (age, sex, department, job and socio-professional category).
Measure: Correlation between socio-economic factors and modalities as well as the experience of confinement Time: at inclusion