Covid 19 Research using Clinical Trials (Home Page)
Report for D004700: Endocrine System Diseases NIH
(Synonyms: Endocrine System Diseases)
Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation
Correlated MeSH Terms (7)
| Name (Synonyms) | Correlation | |
|---|---|---|
| D008659 | Metabolic Diseases NIH | 1.00 |
| D044882 | Glucose Metabolism Disorders NIH | 1.00 |
| D003924 | Diabetes Mellitus, Type 2 NIH | 0.58 |
| D003920 | Diabetes Mellitus, NIH | 0.58 |
| D012140 | Respiratory Tract Diseases NIH | 0.32 |
| D045169 | Severe Acute Respiratory Syndrome NIH | 0.06 |
| D018352 | Coronavirus Infections NIH | 0.05 |
Correlated HPO Terms (3)
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0000818 | Abnormality of the endocrine system HPO | 1.00 |
| HP:0000819 | Diabetes mellitus HPO | 0.58 |
| HP:0005978 | Type II diabetes mellitus HPO | 0.58 |
There is one clinical trial.
Clinical Trials
1 Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients With Established COVID-19
The coronavirus disease 2019 (COVID-19) is an emerging pandemic in 2020 caused by a novel coronavirus named SARS-CoV2. Diabetes confers a significant additional risk for COVID-19 patients. Dipeptidyl peptidase 4 (DPP-4) is a transmembrane glycoprotein expressed ubiquitously in many tissues. In addition to its effect on glucose levels, DPP-4 has various effects on the immune system and several diseases, including lung diseases. This trial aims to assess the safety and efficacy of linagliptin, a DPP-4 inhibitor, in the treatment of COVID-19. The trial will be randomized without blinding, with one are treated by insulin only for glucose balance and the other by insulin and linagliptin. The trial will assess the effects of linagliptin on different measures of COVID-19 recovery.
NCT04371978 COVID 19 Coronavirus Diabetes Mellitus, Type 2 Diabetes Mellitus Glucose Metabolism Disorders Metabolic Disease Endocrine System Diseases Dipeptidyl-Peptidase IV Inhibitors Linagliptin Severe Acute Respiratory Syndrome Coronavirus 2 Sars-CoV2 Hypoglycemic Agents Respiratory Tract Diseases Inc Incretins Hormones Drug: Linagliptin 5 MG MeSH:Coronaviru Coronavirus Infections Severe Acute Respiratory Syndrome Diabetes Mellitus Diabetes Mellitus, Type 2 Metabolic Diseases Glucose Metabolism Disorders Respiratory Tract Diseases Endocrine System Diseases
HPO:Abnormality of the endocrine system Diabetes mellitus Type II diabetes mellitus
Primary Outcomes
Description: Clinical change is defined as 2 points reduction in the World Health Organization (WHO) Ordinal Scale for Clinical Improvement of COVID-19: 0 - No clinical or virological evidence of infection; 1 - No limitation of activities; 2 - Limitation of activities; 3 - Hospitalized, no oxygen therapy; 4 - Oxygen by mask or nasal prongs; 5 - Non-invasive ventilation or high-flow oxygen; 6 - Intubation and mechanical ventilation; 7 - Ventilation + additional organ support - pressors, renal replacement therapy, extracorporeal membrane oxygenation; 8 - Death.
Measure: Time to clinical change Time: 28 days
Secondary Outcomes
Measure: Percent of serious adverse events and premature discontinuation of treatment. Time: 28 days
Description: Percent of patients with a 2 points reduction in the World Health Organization (WHO) Ordinal Scale for Clinical Improvement of COVID-19.
Measure: Percent of patients with clinical improvement. Time: 28 days
Measure: Length of hospitalization. Time: 28 days
Measure: All-cause mortality. Time: 28 days
Measure: Percent of supplemental oxygen use. Time: 28 days
Measure: Supplemental oxygen-free days. Time: 28 days
Measure: Percent of mechanical ventilation use. Time: 28 days
Measure: Ventilator-free days. Time: 28 days
Measure: Percent of ICU admissions. Time: 28 days
Measure: ICU-free days. Time: 28 days
Measure: Percent of 50% decrease in C-reactive protein (CRP) levels Time: Up to 28 days
Measure: Time to virologic response, defined as no detection of SARS-CoV-2 in a PCR test. Time: 28 days
HPO Nodes
HP:0000818: Abnormality of the endocrine system
Genes 1877
SMC1A WHCR CTDP1 MAGED2 DMXL2 TCF4 TRNS2 CASR RRM2B MC2R ALX4 TACR3 TSR2 EXT2 IFT172 HNF1B ATM ABCC8 SETD5 PSMD12 BCL10 FLRT3 FGF17 OCRL CHD7 FANCM HESX1 FOXP3 KCNJ11 CCDC141 IRS2 SOX10 MEIOB SETBP1 TEX14 MALT1 POLR3A RECQL4 CDH23 IGFALS POLG FLI1 TRNN SUFU FOXP1 PIEZO1 ATP6 PRPF4 KCTD1 TUB ZSWIM6 NFIX PRMT7 NRAS NDUFS1 VPS13B CTRC RAP1B MEN1 PTPN11 SOS1 EIF2AK3 EFEMP2 GLI2 SIM1 SDCCAG8 BSCL2 PRPF6 PITX2 CNGA1 WWOX AEBP1 KIAA0556 PDE11A FOXE1 PROK2 XRCC2 PPP1R3A ARHGEF18 SLC29A3 SRD5A2 SOHLH1 PRPF3 POLR3H CDKN2B SGPL1 NKX2-1 ANTXR1 PTDSS1 MAPK8IP1 MLH1 FMR1 POLG RPL10 POR PAX4 AMH FBLN5 TRNS1 H19 PTEN PPARG RAB23 PSAT1 PROK2 PRLR INS MSH3 STX16 SDHC POLR3B GBA STAR GHR ZIC2 LEPR BLM GJA1 BBS12 ERCC2 SDHA FBN1 THOC2 GNAS USP9X GCK MECP2 RPS19 RPL35A HLA-DPA1 GATA6 SDHB SNORD115-1 ARL13B LHX3 NNT BBS1 FOXI1 ADAT3 PNPLA2 GNAS-AS1 STAT1 SLC30A8 SEMA3D POC1A SOX3 FANCM C8ORF37 APC CCDC22 INSR MINPP1 CTNS DNAL4 PROKR2 CYP17A1 BRCA1 PROP1 SUGCT POR STXBP1 RFWD3 HRAS MPI HSD11B2 TBX1 DKC1 LIG4 TXNRD2 FGFR1 ND5 SDHD PEX3 GPC3 CNBP ATAD3A ARL6 ERCC2 LMNA CAV1 RPGRIP1L ABCA4 ADAT3 MAGEL2 TEX11 CEP57 TULP1 HS6ST1 SDHB PEX12 PMM2 FOXA2 SRY HJV WRN VHL DEAF1 BCOR PROP1 MRPS7 HSD17B3 HDAC8 LEMD3 TGFB1 PEX26 STAT5B NDUFS7 NPHP1 VIPAS39 BMP15 TDRD9 GLI3 KCNJ5 PUS1 SLC19A2 NSUN2 PROK2 KRAS PLXND1 PPP1R15B STAT3 FAT4 PEX1 CLDN19 CIDEC PHGDH IGF1 TANGO2 RET ZFP57 ATM COL7A1 ARL3 AKT1 ARMC9 SDHB TRNC BCS1L TERT DCAF17 KCNA1 MAP3K1 SLC26A4 SPRY4 USP7 ND2 SMC3 SDHC CASR TBCE TBX1 GLI2 GNE COL4A5 PDE4D H6PD VAX1 HNF4A CAMKMT BNC1 GH1 LHX1 SRY UBE2T GK SYCE1 RNASEH2B ARL2BP ZBTB20 SCNN1G SCN2A LMNA RPL18 PEX10 NKX2-5 ITPR3 WT1 FUZ FAH SIL1 GATA6 FANCE RIN2 GNAS POU3F4 FAM161A SLC6A17 HNF1A KEAP1 CHD7 PTCH2 GNAS PIK3C2A STAT6 RBM28 FGFR1 ARNT2 RRAS TRIM32 SDHC NDUFV1 SLC19A2 SEC23B SPRY4 RIN2 RPL5 SIK1 NRXN1 PSMC3IP FGFR1 KIAA1549 PPP1R15B DUSP6 NOTCH2 DACT1 HAMP C1QBP SCNN1B ADAR GAS1 SOX10 RPS17 PARN EIF2AK3 TRAPPC11 BMPR1A KDSR HNF1A NKX2-5 BBS12 GLUD1 DNAH1 PMS1 LHB ZMYND15 NEK2 CERKL GPR101 NDUFS8 ND1 LMNA FOXL2 FANCA MSH6 NTN1 PRLR TTC8 TONSL LHX3 APC BRAF PIK3CA FANCM MOG KCNJ11 VHL IL17RD GCM2 EIF2B3 BMP4 RPS15A SOX9 EPCAM NDN MEN1 ABCD1 SECISBP2 HESX1 KAT6B PEX14 TRIP13 UBR1 SMCHD1 RAG1 AKT1 APC ARL6 FLRT3 GCK RASGRP1 PPP2R3C PRPF31 CILK1 SRY ALG1 IGFALS WDR11 NDUFB11 TTPA PCNT GTF2I CTRC HTR1A KCNJ11 PRPH2 LMNA TFR2 BTNL2 CLRN1 SLX4 OPA1 KMT2D NLGN3 KIAA0556 TCOF1 APOE LHCGR PCSK1 KCNJ10 WDR26 FANCI TP53 BMPR1B TRMT10A TRAF3IP1 MMP1 RPE65 AVP PDX1 TANGO2 IGF2BP2 TTC8 IL17RD AHSG SPATA7 PEX6 HNF4A AHR CYB5A GNRHR GPC3 RET RET HJV PEX16 CACNA1C PALLD GNAS TRNE TTC7A OTX2 HYLS1 ARL3 NONO PRKAR1A GATA1 KCNE3 MED12 ARX HNF4A DCAF17 BPTF MLH3 TMEM231 AHI1 CLPB GDNF SEMA3E SPRY4 ARL6IP6 NR5A1 IL2RA BBS10 HGSNAT ABCC8 GABRA3 ATRX GPC4 PAX8 NR0B1 ND5 DMRT1 RRM2B SCARB2 ALX3 SDHAF2 SPINK1 SDHD BEST1 MAP3K7 ABCC8 FSCN2 GABRD FAM111A TBX19 CTBP1 CRX COX3 FGF8 CRB1 SIX3 NKX2-1 STAG3 PEX12 FMR1 TRNS1 ESS2 MKS1 TSHB DAXX PDE4D MST1 MSTO1 MRPS22 VAMP7 TCTN1 KLF11 GNAS PDE4D DNAJC21 CYTB TAC3 INPP5K AKT1 NAB2 EDN3 G6PC3 TP63 CDKN1C SAG KRAS GNAO1 PALB2 PAX8 STUB1 TMEM67 NHP2 MRPS22 FGF8 LIPE RIT1 TDGF1 MERTK FGF17 STEAP3 PHF6 RET DCLRE1C DIS3L2 VPS33B SIL1 CTNS CYP11A1 LMNA TRNQ POLE NDP HSD17B3 SIN3A PAX4 COL7A1 LHCGR PDX1 TRIM8 CC2D2A MDM2 GNAS SLC2A2 PTF1A KCNJ18 KDM6A FANCE PAPSS2 SDHD CFTR PTF1A IL12A LIG4 HLA-DRB1 WT1 SHH MKS1 GAN AMACR ITGB6 ALMS1 NRAS FOXE1 TSC1 PCNT TMEM67 HDAC8 SMC1A CFTR SMCHD1 SRY DHDDS RNF125 FANCD2 WNK4 SOX2 TSHR VHL GLA CDC42 FOXE1 ERCC6 ARMC5 SLC25A11 BIRC3 PTPN22 GUCA1B RFWD3 GCK PDE8B NEUROG3 HSD17B4 FXN GATA4 KCNJ10 SLC16A2 CDKN1B GLA BCS1L ERCC5 FRAS1 YARS2 PAX4 GH1 THRA NR5A1 PPARG GJA1 FLT1 COMT WASHC5 FSHR MKKS PROKR2 WAS NFKB2 CYP11B1 AK2 ROM1 KISS1 PTEN TGFBR2 THRB RAB3GAP2 DDOST CHEK2 COX1 ZMPSTE24 LIPA LIPE AHI1 HS6ST1 ACTG2 FGD1 SIX3 ND4 SDHD TREX1 SEC23B TSHB ZNF423 XPA TRNQ RPS27 RPS26 PTPN22 RAI1 HPGD ELN TGFB1 USF3 COX1 FGF17 XPC PRKAR1A BUB3 H19-ICR NDUFA11 IGSF1 CYP11B2 FANCA AP2S1 DHX38 NSMF BMP15 MAD2L2 FOXI1 TMEM237 GJB4 FOXP3 DMPK RLBP1 WASHC5 KISS1 AR CEP57 BMP4 INS WNT4 WIPF1 TERC CLCNKB CYP27B1 CDKN2A LMNA PTPN11 KISS1R SPINK1 CTLA4 CDKN2C TSHR PLIN1 GPC1 SLC25A22 HNF1B GH1 IFT88 BRCA1 EPAS1 GALT BBS7 NDUFAF4 BBS2 RDH12 CTLA4 IDH1 IDH3A PIGT BBS9 SYCP3 ALG1 CNOT1 DHH PRMT7 EDA2R PEX26 POLR1D INSR SIN3A SLC12A3 PITX2 WFS1 CISD2 GLRX5 IFT27 IL6 LIMK1 MRAP TBL2 ENTPD1 LSS PNPLA6 RBM28 TWNK TRNF TGIF1 POLR3B TSHR CDH23 KIZ MDH2 PRPF8 CPLANE1 PTEN YY1 MARS1 SCN4A RASA2 SOX2 GREM1 PRKAR1A PEX1 TRNW ADAMTSL1 TP53 AR TMCO1 KLHL3 ARNT2 HIRA REV3L BBS10 FGF8 RAD21 HYMAI NDUFAF3 KMT2D INSR ERCC3 FANCF POF1B EIF2B2 TBC1D20 GHR CD36 PLVAP FAS PTH1R SIX1 HLA-DPB1 TXNRD2 INSR DLST POLE PTRH2 MC4R GNA11 APOA5 ADA TMEM138 SLC35A2 FLNB DUSP6 IRF5 NANOS1 NDUFAF5 FGFR1 WFS1 POLR1C KCNJ11 RPL31 TP63 NR5A1 PEX2 PIK3CA COQ2 SOX3 TRNK RAI1 GLI2 TBX2 COG2 NSMF ERGIC1 ATRX SOS2 MKRN3 TBC1D7 RRAS2 SDHB FGFR1 CDH23 PEX6 FOXD3 PIK3R1 IQSEC2 SAA1 CDC73 KCNJ11 KCNJ11 CEP120 ATRX ANK1 PRSS1 TNXB IRX5 ALMS1 PMS2 RCBTB1 GBA HBB EIF2B1 TSC2 ADA2 AIP NR5A1 CASR LETM1 SNAP29 RAD51C AKT2 ABCC8 CDC73 HSD3B2 LHX4 CYP11B2 MTNR1B CDON CEP120 HNF4A IFT172 JAG1 NPM1 ABCC8 PNPLA6 DICER1 MRE11 NRL DMRT3 WNT3 HNF4A BBS4 TP53 MLXIPL GPD2 RNF216 EDA PGM1 GJB2 XRCC2 TRIP4 PWAR1 LMNA CDH23 KCNQ1OT1 CAVIN1 GCM2 PPARG BAZ1B MAX POU1F1 GPR161 CHRNG NDUFV2 PEX5 MEN1 IDH1 GATA3 CPLX1 WDPCP AIP CBX2 SOX3 PTEN CYP21A2 TCF7L2 NOP10 SDHB OTX2 MSH2 CCDC141 TRNW MMEL1 RET SDHA IFT140 CACNA1S NEUROD1 NR0B1 FOXP1 LBR SPIB NF2 WT1 LIPC CISD2 POLR1C SMAD4 NIN WDR11 NDUFA1 GTF2IRD1 CREBBP LMNA PEX19 PEX1 SH2B1 PRKAR1A SRD5A3 EPG5 IL2RG RP1 IDH2 ERCC4 ENTPD1 DUOX2 PEX1 KCTD1 PTH GNRH1 GATA1 TCTN3 GPR101 INSR KCNJ10 TWNK TTC37 IARS2 SIX6 CHD7 PEX11B SHH CTRC TRNL1 ENPP1 ANTXR2 TP53 TSHR TINF2 MAFA HNF1B ZMPSTE24 ZBTB20 AIP CHD7 RPS20 GLIS3 BMPR1A CUL4B SCP2 TRNL2 TBX1 PEX11B B4GALNT1 ND1 RHO SETD2 INS DCLRE1C HBB MEN1 HS6ST1 AIP CLCNKB RPS10 HFE COX2 ZFAT EYA1 GCH1 INS HADH SCNN1B TRAPPC9 HABP2 CORIN USH2A PDX1 LRP5 SCNN1G RAD51 H19 SDHD CP RMRP HRAS SNRPN TSHR PLCD1 MARS2 CDKN1B RECQL4 ND1 NKX2-1 SLC7A14 EDNRB VHL RPL35 THRB FLCN CEP41 IPW TSHR INS INPP5E DGCR2 CDKN1A CCBE1 TMEM216 HADHA HMGA2 AVP RPL26 POLD1 DDX3X DCLRE1C FGFR1 APOA5 PDGFRB CYP2R1 TG ERCC3 POLG2 TEX15 SCAPER SEC24C RAB3GAP2 GLI3 AKT2 NF1 ERCC6 ZFPM2 KLHL10 MSMO1 SLCO2A1 MAP3K1 KCNJ11 DCC FANCC AVPR2 CAV1 SDHB POMC BBIP1 TACR3 WDR4 LMNA OTX2 PNPLA6 BMP2 TBCK ESR1 NNT NANOS1 NR5A1 ERCC4 ZFP57 SLC16A1 BRCA2 SBDS GNAS VPS13A SDHD SDCCAG8 PTPN11 POLR3A DISP1 PEX5 MAP2K1 PDE6G SLC25A13 WDR11 IRS1 ALDOA TSHR GCK ELN GHR PTEN AVPR2 PROM1 PIGP PSMD12 SEMA4A PEX10 MEN1 HNF1A HADHB FGF17 TPO NONO DCC KIF1B KIAA0586 CASK REEP6 PHEX DGCR6 RREB1 CTDP1 RPGRIP1L FANCC GCK DUOXA2 KLLN DDX3X NSDHL G6PC RPS7 MCM4 PPARG DLL1 WRN AQP2 SARS2 GP1BB EFL1 VDR DIS3L2 GPR101 NDUFAF1 MC4R NRTN TWNK SRGAP1 ND6 MAX CACNA1S FOXE3 HYLS1 SP110 UBR1 PUS1 PRTN3 GNRHR PREPL HESX1 ATP7B RPL27 GNRH1 USP8 STUB1 DICER1 CEL DGCR8 OFD1 TRNF MKRN3-AS1 LAS1L NDUFA6 DNAJC19 SMPD1 AK2 CHD7 RAB18 PRDM16 CYP17A1 STK11 STAT3 RPL11 ITCH HNF1A APPL1 CNTNAP2 SKI CYP19A1 CYP17A1 CC2D2A GCGR GLI3 KDM6A RPS29 PTEN USP8 SLC29A3 KIF1B ZMPSTE24 PPM1B B4GALNT1 NKX2-5 VHL AQP2 POMC PDE8B SRP54 SLC12A1 SLC3A1 WNT4 SLC39A4 SMARCAL1 HESX1 BBS4 RERE NDUFS4 SPIDR ERF RPGR MSH3 ABCC6 TAF13 EIF2S3 FANCL PDX1 SDHB PEX14 LEPR FUCA1 WFS1 INSR ELMO2 ESR2 NSD2 CEP19 NDUFS6 TAC3 POU2AF1 SMARCB1 RAP1A WDR11 CLIP2 ERCC8 PEX5 FSHR HSD11B2 CAVIN1 MKKS CP TMEM127 ANOS1 GNAS FANCI HSD3B2 FAM111A GCGR CEP290 GLI2 TIMMDC1 TMEM127 SHH STAR LMNA FOXH1 TBC1D24 PROKR2 NLRP3 CYP11A1 USB1 TMEM67 TRH KISS1R NKX2-1 ADA RAG2 PCSK1 PRSS1 KCNQ1 FDX2 GH1 FOXE1 NR0B1 TF IL2RG STEAP3 CASR HPD RET PROP1 PEX6 LMNA KCNJ18 B9D1 KRAS ANOS1 TRIM32 SDHAF2 DUOX2 SLC26A4 GNAS MGME1 ANOS1 IGH SOX9 RNF216 TBX19 USP9X FANCD2 GNAS BBS2 OTX2 AMHR2 SMAD4 PRKAR1A GMPPA NEUROD1 BRCA2 POU1F1 KCNJ1 DLST SEMA3A TRNE SDHC MGME1 PRKAR1A SEMA3E TRNW IL2RA LRAT SLC37A4 GHSR PRKAR1A APC2 KMT2A SAMD9 TRNH ERCC1 PEX3 PDE6A CLCNKA RNU4ATAC GPR35 NUP107 TBX1 TFAP2A PRKCD KCNJ5 KISS1R AIP NSMCE3 HESX1 TBX3 LMNA TTC8 PEX13 SLC25A11 NUBPL SNRPN SEMA3C FMR1 ATRX TBX3 AHI1 PTCH1 HESX1 NPAP1 BBS5 FAN1 CDC73 POLA1 C1S PDX1 LRP4 HADH SOST CUL3 VPS13B APC BBS5 AIRE CTC1 NSMCE2 FSHB TAF4B MCM8 XRCC4 SOX3 SRY KLF11 ALX4 MAB21L2 CYP11A1 LHX4 PTCH1 PLAGL1 NR3C2 PRSS1 C8ORF37 SLC26A4 TSC1 AGPAT2 PDE11A IYD PEX13 POLR3A TNFSF15 CYP27B1 CEP104 APPL1 LAS1L PEX6 RORC NECTIN1 CCDC141 IER3IP1 DCLRE1C AVPR2 HYMAI PREPL MAK BSCL2 FEZF1 PLCG2 SOX10 XRCC4 MCOLN1 FASLG PWRN1 CLCNKB KCNJ11 STOX1 BUB1 BBS2 IGF1R PRKACA BSCL2 SDHD UCP2 RP9 LHX4 POLR3A GDF9 TRNL1 SLC26A4 STS WFS1 LMNB2 MYH3 GPC4 SUFU MKS1 EIF2B4 HDAC8 GNAS PEX2 POLA1 ESR1 RPL15 KISS1R WNK1 KMT2A NEUROD2 ZFYVE26 NDE1 DNMT3A LZTR1 GCK PTEN SEMA4A UFD1 SCNN1A PAX8 FSHB RNASEH2A LRBA IFT74 B3GLCT FGFRL1 LHX3 TG FOS IDH3B CACNA1D CASR XRCC4 JMJD1C RAF1 PROP1 IFNG PALB2 RAG2 PHGDH SLC5A5 ND3 KRAS THRB SNORD116-1 TBCE NR5A1 FUT8 LHCGR CEL NSD1 HMGA1 NDUFS2 RETN RAD51 AAAS CDC73 LRP6 CAT HNF1A CTNNB1 PAX8 COX2 INSR PEX19 PRCD SEMA3E PIGQ PROKR2 PCARE HYMAI CDC73 POLR3B FGF8 TNPO3 SLC25A4 ZNF513 CCND1 AKT2 MMP2 SDHC SLC52A2 ADNP LEP HFM1 GDNF TRNL1 CSPP1 NRAS CYP11B1 TRNL1 AMACR GMNN PTPN1 SUFU RAC1 FMR1 ACP5 PRPS1 STRADA POU1F1 SOX3 KCNJ11 PDX1 NFKB2 WNT4 PDE6B RPS24 LIFR TBCE CDKN1C BRAF BTK CYP11B2 ABCC8 ABCC8 FXN PITX2 RGR HNF1A RAG1 ZMPSTE24 CBX2 CDKN1B GLUD1 CPA1 ERCC5 CUL4B TRMT10A FANCB ABCC8 RPS28 PDGFB CYP11B1 PLIN1 PTCH1 NDUFAF2 CDC73 HLA-DRB1 CACNA1D KAT6B TBCE NDUFB9 FOXRED1 MMP14 RP2 HNF1A RNPC3 WRAP53 GHSR RFC2 HNF4A PHF6 CEP41 STRADA CFTR SHROOM4 ND6 DNAJC3 FOXC1 INPP5E WFS1 EP300 NEK9 SRY MC2R NLGN4X ARSL TRNL1 VDR NODAL PNPLA2 FEZF1 PMM2 SPINK1 DICER1 PIK3R1 LIPA POR HACE1 FOXC2 SOX9 TMEM237 SCN4A TACR3 CLPP PLAGL1 POMGNT1 KCNAB2 CHD7 AGPAT2 ENPP1 POLG MRAP PEX16 FSHR LZTFL1 INS BLK SLC37A4 IMPG2 CEP290 GATA3 RBP3 PROKR2 ATP8 ARMC5 TOPORS DNM1L GJB3 DNAJC3 IDH2 STX16 GCM2 IL7R NDUFS3 PIBF1 HERC2 TCTN2 EXOSC2 TKT NSMCE2 APC IFIH1 DUSP6 TP53 RAI1 AFF4 IQSEC2 COG2 LIG4 BBS1 CYP11B2 NPHP1 BRIP1 RAB3GAP1 CACNA1S IGF2 NIPBL NR2E3 ALG8 SLC26A3 PEX10 TMEM126B MEN1 TPO KLHL7 DHCR7 BUB1B RET HABP2 CNGB1 POLR3B GCK ERCC2 DBH STAT1 AGBL5 RAB3GAP2 IL12RB1 INPP5E MINPP1 PTPN22 CA4 TRHR SPINK1 TRNK PAX4 WNT4 EYS MAGEL2 GNAS IGF2 MSTO1 LIPA MKS1 FLII FOXE1 TMEM237 MKRN3 NSMF HNF1B SKIV2L TG SLC12A3 RTEL1 POLG LHX4 CCDC28B CDKN1C SCN1B GNRH1 DDB2 TBX1 IFT27 NR0B1 TP53 TRNV PIK3CA NDUFB10 TRNS1 AR ZSWIM6 ZNF408 MCTP2 SLC5A5 CYP19A1 EIF2B5 AXL TSC2 CDHR1 BSND CASP10 GCM2 HSD17B4 ZNF148 ROBO1 HAMP NPHS1 TWNK DMXL2 ARVCF DUOXA2 COX3 AAAS RNU4ATAC POLR3A PLAA CDKL5 ABCC8 CYP11B1 RNASEH2C TYMP IL17RD IARS2 FH LZTFL1 SLC7A7 HFE SRA1 NLRP1 CBL PUF60 SLC16A2 FAM111B FAM20A DMPK AIRE TRNS2 NR3C1 SRD5A2 FANCG PDE4D NR5A1 SAMHD1 NKX2-5 LIG4 PNPLA6 TSHR PRSS2 PRKACA FLCN BLK RRM2B EIF2S3 SNRNP200 IYD NEUROD1 PHF21A PEX5 NR3C2 RAB3GAP1 FANCB DUOX2 PSTPIP1 ZMPSTE24 HLA-DQB1 SLC52A3 SASH1 DCHS1 TTC7A PNPLA6 ECE1 PTH1R APC PRSS2 SDHD FEZF1 SALL1 IMPDH1 PNKP MRAS NDUFB3 FAS HSD11B1 SALL1 CDON DHH LEP VANGL1 CDKN2A A2ML1 Protein Mutations 0
SNP 0
Primary Outcomes
Description: Clinical change is defined as 2 points reduction in the World Health Organization (WHO) Ordinal Scale for Clinical Improvement of COVID-19: 0 - No clinical or virological evidence of infection; 1 - No limitation of activities; 2 - Limitation of activities; 3 - Hospitalized, no oxygen therapy; 4 - Oxygen by mask or nasal prongs; 5 - Non-invasive ventilation or high-flow oxygen; 6 - Intubation and mechanical ventilation; 7 - Ventilation + additional organ support - pressors, renal replacement therapy, extracorporeal membrane oxygenation; 8 - Death.
Measure: Time to clinical change Time: 28 daysSecondary Outcomes
Measure: Percent of serious adverse events and premature discontinuation of treatment. Time: 28 daysDescription: Percent of patients with a 2 points reduction in the World Health Organization (WHO) Ordinal Scale for Clinical Improvement of COVID-19.
Measure: Percent of patients with clinical improvement. Time: 28 daysMeasure: Length of hospitalization. Time: 28 days
Measure: All-cause mortality. Time: 28 days
Measure: Percent of supplemental oxygen use. Time: 28 days
Measure: Supplemental oxygen-free days. Time: 28 days
Measure: Percent of mechanical ventilation use. Time: 28 days
Measure: Ventilator-free days. Time: 28 days
Measure: Percent of ICU admissions. Time: 28 days
Measure: ICU-free days. Time: 28 days
Measure: Percent of 50% decrease in C-reactive protein (CRP) levels Time: Up to 28 days
Measure: Time to virologic response, defined as no detection of SARS-CoV-2 in a PCR test. Time: 28 days