CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Report for D013315: Stress, Psychological NIH

(Synonyms: Stress, Psych, Stress, Psychol, Stress, Psychological)

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (8)


Name (Synonyms) Correlation
drug596 Internet-based guided self-help based on CBT principles Wiki 0.38
drug826 Patient management suffering of coronavirus infection Wiki 0.38
drug703 MinnRAP Peer Support Program Wiki 0.38
drug929 Questionnaires on psychological quality of life Wiki 0.38
drug1044 Software Messaging Wiki 0.38
drug269 Chlorpromazine Injection Wiki 0.38
drug173 Blood draw Wiki 0.27
drug208 COVID-19 Convalescent Plasma Wiki 0.19

Correlated MeSH Terms (13)


Name (Synonyms) Correlation
D019973 Alcohol-Related Disorders NIH 0.38
D015207 Osteoarthritis, Hip NIH 0.38
D015775 Fractures, Stress NIH 0.38
D010003 Osteoarthritis, NIH 0.38
D000068376 Compassion Fatigue NIH 0.38
D000067073 Psychological Trauma NIH 0.38
D020370 Osteoarthritis, Knee NIH 0.38
D000428 Alcohol Drinking NIH 0.38
D000077062 Burnout, Psychological NIH 0.22
D040921 Stress Disorders, Traumatic NIH 0.22
D013313 Stress Disorders, Post-Traumatic NIH 0.19
D004194 Disease NIH 0.17
D001008 Anxiety Disorders NIH 0.13

Correlated HPO Terms (3)


Name (Synonyms) Correlation
HP:0002758 Osteoarthritis HPO 0.38
HP:0008843 Hip osteoarthritis HPO 0.38
HP:0005086 Knee osteoarthritis HPO 0.38

There are 7 clinical trials

Clinical Trials


1 The COVISTRESS Study: Influence of the COvid-19 Epidemic on STRESS

The Coronavirus has a major influence on stress for the general population. However, data are currently non-existent concerning the perception and knowledge of the epidemic, the feeling of information from companies / establishments / governments, the means of protection used, the feelings of fear generated and their impact on feelings of stigmatization towards certain ethnic groups or categories of patients (those who cough ...), or relationships with socio-demographic factors or lifestyle.

NCT04308187 Stress, Psychological
MeSH:Stress, Psychological

Primary Outcomes

Description: Stress level will be assessed by questionnaire

Measure: Stress

Time: Day 1

Secondary Outcomes

Description: Perception and knowledge of the epidemic will be assessed by questionnaire

Measure: Perception and knowledge of the epidemic

Time: Day 1

Description: The feeling of information will be assessed by questionnaire

Measure: Feeling of information on the part of companies / establishments / governments

Time: Day 1

Description: the means of protection used will be assessed by questionnaire

Measure: Means of protection

Time: Day 1

Description: The feeling of fear and the impact on stigmatization will be assessed by questionnaire

Measure: Feelings of fear generated and its impact on feelings of stigmatization towards ethnic groups or categories of patients

Time: Day 1

Description: Sociodemographic factors and lifestyle habits will be assessed by questionnaire

Measure: Sociodemographic factors and lifestyle habits

Time: Day 1

2 Acceptance and Commitment Therapy Delivered by Automated Software Messaging

This study aims to 1) observe the course of pain, 2) mental status, and 3) possible effect of a behavioral intervention delivered via an automated mobile phone messaging robot in patients were indicated and/or scheduled to undergo joint replacement but have been cancelled or delayed due to the COVID-19 crisis.

NCT04329897 Hip Osteoarthritis Knee Osteoarthritis Mental Stress Coronavirus Behavioral: Software Messaging
MeSH:Osteoarthritis Osteoarthritis, Knee Osteoarthritis, Hip Stress, Psychological
HPO:Hip osteoarthritis Knee osteoarthritis Osteoarthritis

Primary Outcomes

Description: PROMIS Pain Intensity 3A short form is a 3 question survey measuring an individual's pain over the past 7 days. It utilizes a scale of 1 (no pain) to 5 (very severe pain) for all questions. The scores for the 3 questions are summed and then matched to a corresponding t-score for the instrument. The corresponding t-score is the final, reportable score and can range from 30.7 to 71.8 for the PROMIS Pain Intensity 3A instrument. Higher t-score values represent worse pain outcomes. More information on this instrument, including a scoring manual, can be found at http://www.healthmeasures.net

Measure: Change in reported pain intensity score (PROMIS Pain Intensity 3A) Patient-reported outcomes measurement information system Pain Intensity (PROMIS) 3A short form scores collected from all participating subjects.

Time: Measurements assessed via a computer interface of the standardized form listed above on the day of enrollment and on day fourteen, via telephone.

Description: PROMIS Pain Intensity 1A short form is a 1 question survey measuring an individual's average pain over the past 7 days. It utilizes a scale of 0 (no pain) to 10 (worst imaginable pain). Higher values represent worse pain outcomes. More information on this instrument, including a scoring manual, can be found at http://www.healthmeasures.net

Measure: Change in reported pain intensity score (PROMIS Pain Intensity 1A) Patient-reported outcomes measurement information system Pain Intensity (PROMIS) 1A short form scores collected from all participating subjects.

Time: Measurements assessed via a computer interface of the standardized form listed above on the day of enrollment and on day fourteen, via telephone.

Description: The PROMIS Pain Interference 8A short form is an 8 question survey that measures how much pain has interfered in the respondent's life over the past 7 days. It utilizes a scale of 1 (not at all) to 5 (very much) for all questions. The scores for all 8 questions are summed and then matched to a corresponding t-score for the instrument. The corresponding t-score is the final, reportable score and can range from 40.7 to 77.0 for the PROMIS Pain Interference 8A instrument. Higher t-score values represent worse pain interference outcomes. More information on this instrument, including a scoring manual, can be found at http://www.healthmeasures.net

Measure: Change in reported pain interference score Patient-reported outcomes measurement information system (PROMIS) Pain Interference 8A short form scores collected from all participating subjects.

Time: Measurements assessed via a computer interface of the standardized form listed above on the day of enrollment and on day fourteen, via telephone.

Description: The PROMIS Emotional Distress-Anxiety 8A short form is an 8 statement survey that measures how much emotional distress, specifically due to anxiety, a respondent has experienced over the past 7 days. It utilizes a scale of 1 (never) to 5 (always) for all the statements. The scores for all 8 statements are summed and then matched to a corresponding t-score for the instrument. The corresponding t-score is the final, reportable score and can range from 37.1 to 83.1 for the PROMIS Emotional Distress-Anxiety 8A instrument. Higher t-score values represent worse anxiety caused emotional distress outcomes. More information on this instrument, including a scoring manual, can be found at http://www.healthmeasures.net

Measure: Change in reported emotional distress (anxiety) score. Patient-reported outcomes measurement information system (PROMIS) Emotional Distress-Anxiety 8A short form scores collected from all participating subjects.

Time: Measurements assessed via a computer interface of the standardized form listed above on the day of enrollment and on day fourteen, via telephone.

3 Burnout Among Caregivers Facing COVID-19 Health Crisis at a Non-conventional Intensive Care Unit Compared to a Conventional Intensive Care Unit

The intense health crisis due to COVID-19 led to a profound reorganization of the activities at theatres, recovery rooms and the intensive care units. The caregivers are facing several issues and are daily exposed to an intensification of the work. Assessing the stress and the well-being of the caregivers is very important in this context.

NCT04346810 COVID-19 Burnout, Caregiver Intensive Care Unit Stress, Psychological Other: Patient management suffering of coronavirus infection
MeSH:Burnout, Psychological Stress, Psychological

Primary Outcomes

Description: stress level of caregivers managing patients with coronavirus infection needing airway support or resuscitation. The level of stress will be quantified with the Maslach burnout Inventory.

Measure: Stress in a recovery room transformed into an intensive care unit versus a conventional intensive care unit

Time: A 3 months period from the starting of the pandemic

4 Impact of the COVID-19 Pandemic on the Quality of Psychological Life of Healthcare Professionals

The COVID-19 pandemic is profoundly changing the way people live and work. After the health impact, it is the mental and psychological impact that reaches varying degrees in the entire world population. The previous Asian epidemics have had a lasting impact on the health professionals concerned. In France, no study has yet assessed the psychological impact of this health crisis on the level of health professionals. Investigators propose to study prospectively the evolution of the state of stress and anxiety of all the professionals practicing within the gynecology-obstetrics departments of 18 French hospitals. Investigators also hypothesize that the mental repercussions in terms of stress and anxiety within the same service could be different depending on the professional status and the place of exercise (the French regions being impacted in different ways). In addition to the epidemiological interest, the results of this study may help us to target regions and professionals who will need psychological support during and after this serious health crisis.

NCT04375644 Covid 19 Stress, Psychological Other: Questionnaires on psychological quality of life
MeSH:Stress, Psychological

Primary Outcomes

Description: Stress state score, during the confinement period, established by a comparison VAS (visual analogue scale) compared to a period outside COVID-19 (from -5: considerable degradation to +5: considerable improvement, with 0: no change)

Measure: Stress state score, during the confinement period

Time: About 10 minutes ( Questionnaire filling time)

5 COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study

Background: The SARS-CoV-2 virus has caused a pandemic infection called COVID-19. It is a global threat to people, communities, and health systems. Researchers are concerned about the mental health effects of the pandemic. They want to learn more about how it is affecting people s alcohol use and problems, and how it may continue to affect them over time. Objective: To study the impact of the COVID-19 pandemic on alcohol use and consequences in individuals across the spectrum of alcohol use and those with alcohol use disorder. Eligibility: Participants who have been screened under the NIAAA Screening, Assessment and Management Protocol (14-AA-0181) Design: Participants will complete a baseline survey by phone. It will ask about alcohol use, alcohol dependence, and stress. It covers 2 time periods: the 12 months before the pandemic started and the time since it started. Participants will get an ID code and a link to an online survey. They will complete the online survey within a week of the phone survey. Participants will complete a series of online surveys over 24 months. For the first year, surveys will be completed weekly for the first 4 weeks, then biweekly for the next 8 weeks, and then every 1-2 months for the rest of the year. For the second year, surveys will be completed every 6 months. Surveys will cover the following topics: - Alcohol use and its consequences - Other substance use - Stress - Impact of the COVID-19 pandemic - Pain - Physical health - Sleep - Quality of life. Because the course of the pandemic may change, the frequency of the surveys may change. Participation lasts 2 years.

NCT04391816 Alcohol Drinking Alcohol-Related Disorders Pandemic Psychological Stress
MeSH:Alcohol-Related Disorders Alcohol Drinking Stress, Psychological

Primary Outcomes

Description: Alcohol Use Disorder Identification Test (AUDIT): This is a 10-item questionnaire designed to screen for AUD. The first 3 questions constitute the AUDIT-C and provides a measure of alcohol consumption. The total score provides a continuous quantification of AUD severity.

Measure: AUDIT Score

Time: 24 months

Description: Alcohol Dependence Scale (ADS): This 25-item scale will be used to measure severity of alcohol dependence. This scale covers alcohol withdrawal symptoms, impaired control over drinking, awareness of a compulsion to drink, increased tolerance to alcohol, and salience of drink-seeking behavior.

Measure: ADS Score

Time: 24 months

Secondary Outcomes

Description: Life Events Questionnaire (LEQ): This questionnaire assesses positive and negative life events and their impact on participants

Measure: Life Events Questionnaire (LEQ) Score

Time: 24 monhts

Description: UCLA Loneliness Scale (UCLALS): This is a 20-item scale designed to measure a person s subjective feeling of loneliness and social isolation in the last month

Measure: UCLA Loneliness Scale (UCLALS) Score

Time: 24 months

Description: Perceived stress scale (PSS): This is a 10-item scale to measure perception of stress

Measure: Perceived Stress Scale (PSS) Score

Time: 24 months

6 Pilot Internet-based Self-Help Program for Managing Corona Stress vs. Waitlist Control

The current study examines an adapted guided self-help stress reduction program, focusing on reducing stress in the time of COVID-19. Two studies are planned: 1) an international study in English in which individuals proficient in English throughout the world will participate and 2) a follow-up study in Hebrew.

NCT04394403 Stress Stress, Psychological Behavioral: Internet-based guided self-help based on CBT principles
MeSH:Stress, Psychological

Primary Outcomes

Description: change in a self-report measure of stress during the COVID-19 pandemic that ranges from 0-128. Higher means more symptomatic.

Measure: The CoRonavIruS Health Impact Survey (CRISIS)

Time: change from Pre to post treatment (6 weeks),

Description: change in a self-report measure of stress during the COVID-19 pandemic that ranges from 0-128. Higher means more symptomatic.

Measure: The CoRonavIruS Health Impact Survey (CRISIS)

Time: change from Pre to 6 mos Follow-up

Description: change in a self-report measure of stress during the COVID-19 pandemic that ranges from 0-128. Higher means more symptomatic.

Measure: The CoRonavIruS Health Impact Survey (CRISIS)

Time: change from Pre to 1 year Follow-up

Secondary Outcomes

Description: a self-report measure of depression, anxiety and stress, with each subscale ranging from 0-28. Higher means more symptomatic.

Measure: Depression, Anxiety, and Stress Scale- 21 item version: DASS-21

Time: Weekly change during treatment and at pre and post (6 week) treatment evaluations

Description: a self-report measure of depression, anxiety and stress, with each subscale ranging from 0-28. Higher means more symptomatic.

Measure: Depression, Anxiety, and Stress Scale- 21 item version: DASS-21

Time: change from pre to 6 month follow up

Description: a self-report measure of depression, anxiety and stress, with each subscale ranging from 0-28. Higher means more symptomatic.

Measure: Depression, Anxiety, and Stress Scale- 21 item version: DASS-21

Time: change from pre to 1 year follow-up

Other Outcomes

Description: how many modules each individual completes, with less than 2 being considered dropout

Measure: completion rate of modules

Time: 6 weeks

7 The Professional Peer Resilience Initiative: Leveraging a Data-Driven Model to Maximize the Resilience of Healthcare Workers During the COVID-19 Pandemic

The Professional Peer Resilience Initiative (PPRI) study is an observational study aimed at understanding how symptoms of traumatic stress and resilience evolve over time in the University of Minnesota (UMN) healthcare workforce during the coronavirus disease 2019 (COVID-19) pandemic. The study is being conducted concurrently with a UMN peer support program called the MinnRAP program and will remotely administer quality of life and mental health surveys to healthcare workers before they start the MinnRAP program and throughout their participation in the program.

NCT04396600 Stress Stress Disorder Stress, Psychological Trauma, Psychological Anxiety Anxiety State Post Traumatic Stress Disorder Secondary Traumatic Stress Professional Quality of Life Stress Related Disorder Stress Reaction Stress Risk Mental Resilience Emotional Resilience Behavioral: MinnRAP Peer Support Program
MeSH:Disease Compassion Fatigue Fractures, Stress Anxiety Disorders Stress Disorders, Traumatic Stress Disorders, Post-Traumatic Stress, Psychological Psychological Trauma

Primary Outcomes

Description: Professional Quality of Life Questionnaire (proQOL): min score of 10; max score of 50; higher scores mean worse outcome

Measure: Change in professional quality of life

Time: Before peer support program, through study completion (an average of 7 months)

Secondary Outcomes

Description: Stress Risk & Resilience Self-Index: min score 0; max score of 12; higher scores mean worse outcome

Measure: Change in mental health symptoms and resilience markers

Time: Before peer support program, through study completion (an average of 7 months)


HPO Nodes