Name (Synonyms) | Correlation | |
---|---|---|
drug1004 | Saline Control Wiki | 0.58 |
drug831 | Pectin Wiki | 0.58 |
drug1355 | no intervention-mechanistic study Wiki | 0.58 |
drug36 | Acacia Senegal Wiki | 0.58 |
drug666 | MSC Treatment Wiki | 0.58 |
Name (Synonyms) | Correlation | |
---|---|---|
D018746 | Systemic Inflammatory Response Syndrome NIH | 0.33 |
D058186 | Acute Kidney Injury NIH | 0.24 |
D013577 | Syndrome NIH | 0.08 |
D055371 | Acute Lung Injury NIH | 0.08 |
D012127 | Respiratory Distress Syndrome, Newborn NIH | 0.07 |
D012128 | Respiratory Distress Syndrome, Adult NIH | 0.06 |
D011014 | Pneumonia NIH | 0.04 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.03 |
D018352 | Coronavirus Infections NIH | 0.03 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0001919 | Acute kidney injury HPO | 0.24 |
HP:0002090 | Pneumonia HPO | 0.04 |
There are 3 clinical trials
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
Description: KDIGO AKI score
Measure: Acute Kidney Injury Time: During Intensive Care, an estimated average of 10 days.Description: Acute Respiratory Distress Syndrome yes/no
Measure: ARDS Time: During intensive care, an estimated average of 10 days.Description: Death within 30 days of ICU admission
Measure: 30 day mortality Time: 30 daysDescription: Death within 1 year of ICU admission
Measure: 1 year mortality Time: 1 yearDescription: Development of Chronic Kidney Disease
Measure: Chronic Kidney Disease Time: 60 days and 1 year after ICU admissionDescription: Sequential Organ Failure Score as a continuous variable
Measure: SOFA-score Time: During Intensive Care, an estimated average of 10 days.This study aims to use the regenerative and repair abilities of stem cells to fight against the harmful effects of the novel coronavirus Covid-19 and therefore develop a treatment strategy. It is known that fatalities from this virus is largely caused by its damage to lungs and other organs. As the disease progresses, these organs fail and lead to mortality. Our hope is that the stem cell transplantation from healthy donors will repair the damage caused by the virus and result in a healthy recovery.
Description: Improvement of clinical symptoms related to Covid-19 infection (fever, pneumonia, shortness of breath)
Measure: Clinical improvement Time: 3 monthsDescription: Improvement of lungs assessed by CT Scan
Measure: Lung damage improvement Time: 3 monthsDescription: Negative, measured by RT-PCR laboratory tests for the virus
Measure: Sars-Cov-2 viral infection laboratory test Time: 3 monthsDescription: Cell types and numbers
Measure: Blood test Time: 3 monthsIn the United Kingdom, there are currently 138,000 confirmed patients with coronavirus, causing 18,738 deaths. Whilst the disease may be mild in the majority of patients, a significant proportion of patients require intensive care therapy and a ventilator due to lung injury. In addition to lung injury/failure (acute respiratory distress syndrome (ARDS)), around 50% of patients admitted to intensive care develop acute kidney injury (AKI) (requiring advanced support via haemofiltration) and multi-organ failure. It is unclear why patients suffering from COVID-19 develop such severe lung injury (requiring life support or ventilation) or indeed why patients develop other organ dysfunction such as kidney injury. The investigators hypothesis that this may due to an over-reaction of the immune system particularly in the lungs. This then results in the release of various mediators and biological messengers which can be pushed into the blood bloodstream (exacerbated by positive pressure generated by the ventilator). These mediators then travel, via the blood, to other organs such as the kidney where they cause inflammation and injury of cells, resulting in organ failure. At the Imperial College London (specifically at the Hammersmith Hospital campus) the investigators are in the unique position to investigate the pathophysiology of multi-organ failure as we are a referral centre for patients with COVID-19 who have developed renal and multi-organ failure (the hospital has accepted a number of these patients from various hospitals across the region). The Division of Anaesthetics, Pain Medicine and Intensive Care at Imperial College London, headed by Professor Masao Takata, has an international reputation, investigating the mechanisms of organ injury and failure (particularly lung injury) in critical care patients (non-viral causes). The investigators would like to apply well-established methods to try and further the scientific community's knowledge of this severe and deadly viral condition. The investigators hope that this would lead to the development of medication that would treat this deadly virus.
Description: This will involve measurement of microvesicles in blood
Measure: Variation in inflammatory mediators in patients with multi-organ failure suffering from COVID-19 Time: 18 monthsDescription: This will involve measurement of microvesicles in bronchoalveolar lavage fluid
Measure: Variation in inflammatory mediators in patients with multi-organ failure suffering from COVID-19 Time: 18 monthsDescription: This will involve measurement of microvesicles in urine
Measure: Variation in inflammatory mediators in patients with multi-organ failure suffering from COVID-19 Time: 18 monthsDescription: The aforementioned inflammatory markers will be correlated with level fo lung injury which will be based upon the level of oxygen required by patients.
Measure: Correlation of inflammatory mediators in the bronchoalveolar lavage fluid with extent of lung injury (e.g. based upon oxygen requirement) Time: 18 monthsDescription: The aforementioned inflammatory markers will be measured in renal outcomes (creatinine and urine output) and cardiovascular markers (e.g. natriuretic peptides (BNP and NT pro-BNP) and Troponin).
Measure: Correlation of circulating inflammatory mediators with renal and cardiovascular markers Time: 18 months