Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
Name (Synonyms) | Correlation | |
---|---|---|
drug411 | Atezolizumab Wiki | 0.71 |
drug1133 | Convalescent COVID 19 Plasma Wiki | 0.71 |
drug1546 | Etoposide Wiki | 0.71 |
Name (Synonyms) | Correlation | |
---|---|---|
D018288 | Carcinoma, Small Cell NIH | 0.71 |
D055752 | Small Cell Lung Carcinoma NIH | 0.58 |
D009369 | Neoplasms, NIH | 0.15 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0030357 | Small cell lung carcinoma HPO | 0.58 |
HP:0002664 | Neoplasm HPO | 0.15 |
Navigate: Correlations HPO
There is one clinical trial.
This phase I trial identifies the best dose and side effects of entinostat in combination with atezolizumab, carboplatin and etoposide for the treatment of previously untreated aggressive lung cancer that has spread (extensive-stage small cell lung cancer). Entinostat and etoposide may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving entinostat in combination with atezolizumab, carboplatin and etoposide may work better than atezolizumab, carboplatin and etoposide alone.
Description: The Bayesian optimal interval (BOIN) design will be used to find the MTD based on safety.
Measure: Maximum tolerated dose (MTD) Time: Up to 21 daysDescription: Defined by Common Terminology Criteria for Adverse Events version 5.0. Will be summarized by frequency and magnitude.
Measure: Grade 3/4 adverse event rate Time: Up to 30 daysDescription: The proportion of participants who receive 3 or more cycles of the combination, will be calculated with a 90% confidence interval.
Measure: Number of cycles received of the combination of entinostat, atezolizumab, carboplatin, and etoposide Time: Up to cycle 4 (1 cycle = 21 days)Description: Defined as the proportion of patients alive and without disease progression after 9 months from study enrollment. The 9 month PFS rate will be estimated with a 90% confidence interval. The Kaplan Meier estimator will be used to estimate survival curves.
Measure: 9-month progression free survival (PFS) rate Time: 9 monthsAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on December 13, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports