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Sections: Correlations,
Clinical Trials, and HPO
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drug3256 | Placebo intravenous Wiki | 1.00 |
drug2565 | Melatonin intravenous Wiki | 1.00 |
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D045169 | Severe Acute Respiratory Syndrome NIH | 0.04 |
D018352 | Coronavirus Infections NIH | 0.03 |
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Navigate: Correlations HPO
There is one clinical trial.
"Sit-to-stand" is key to independent living. For intensive care unit (ICU) survivors, failure to perform sit-to-stand results in bed-bound status, unable participating in important activities of daily living (ADLs) or instrumental ADLs. Recent studies indicated that 31% of ICU survivors remained bed-bound and unable to "sit-to-stand" after returning home. Our preliminary findings further indicated that 70% of ICU survivors who had the ICU-acquired weakness (ICU-AW) were unable to "sit-to-stand" one-month after ICU discharge. The aim of this 3-year research project was to develop a feasible and effective "sit-to-stand" care (STS Care). A randomized controlled trial (RCT) design is proposed to examine effects of the STS Care in improving ICU patients' "sit-to-stand" ability, physical function, and rates of bed-bound and mortality one year following ICU discharge. The trial was approved by the Human Research Ethics Committee at the study site before enrollment. Adult ICU patients (≥ 20 years) admitted consecutively to six medical ICUs of a university affiliated medical center was eligible for the study if they were unable to "sit-to-stand" independently at ICU discharge. Upon signing informed consent, participants will be first stratified by "able to remain sitting upright without falling" or "unable to remain sitting upright" and then randomized separately into the intervention or usual care groups, according to computer-generated randomization tables. Participants in the intervention group received both usual care and the STS Care. The hospital-based (up to 14 days) STS Care, which was provided daily by the same trained nurse, consisted of nurse-supervised anti-gravity and resistant exercise (intensity based on patients' tolerance), repetitive sit-to-stand practice, and advice on sit-to-stand strategies. A comprehensive functional evaluation (success rate of sit to stand, scores of FSS-ICU, scores of MRC muscle scale, muscle strength at knee extensors, scores of the barthel index for activities of daily living (ADL), scores of instrumental activities of daily living scale (IADL), the walking distance by the 6-minute walk test, numbers of sit-to-stand repetitions in 30 seconds, rate of bed-bound status, rate of mortality) was assessed by blinded research nurses after ICU discharge at 5 time points:48hours, 14 day, 1, 3, and 12 months.
Description: Evaluated by one successful and independent sit-to-stand, allowed armrest use (yes/no)
Measure: Change from baseline success rate of sit to stand (%) Time: Baseline within 48 hours. 14 day, 1, and 3 months after ICU discharge.Description: The FSS-ICU use 7-points score to evaluated 5 functional tasks, which includes rolling, supine-to -sit transfer, unsupported sitting, sit-to-stand transfer, and ambulation. Score range from 0 to 35, higher score indicated better physical performance.
Measure: Change from baseline scores of FSS-ICU Time: Baseline within 48 hours. 14 day, 1, and 3 months after ICU discharge.Description: Measured by medical research council scale (MRC) in score, range from 0 to 60 score, higher score indicated better muscle strength
Measure: Change from baseline scores of MRC muscle scale Time: Baseline within 48 hours. 1, 3, and 12 months after ICU discharge.Description: Measured by Hoggan MicroFET®2 in kg
Measure: Change from baseline muscle strength(kg) at knee extensors Time: Baseline within 48 hours. 14 day, 1, 3, and 12 months after ICU discharge.Description: Measured by recording the numbers of sit-to-stand a person can complete in 30 seconds
Measure: Change from baseline numbers of sit-to-stand repetitions in 30 second Time: 14day, 1, and 3 months after ICU discharge.Description: Measured by ADL in score, range from 0-100 score, higher score indicated health condition
Measure: Scores of the barthel index for activities of daily living (ADL) Time: Baseline within 48 hours. 1, 3, and 12 months after ICU discharge.Description: Measured by IADL in score, range from 0 to 8 score, higher score indicated better health condition
Measure: Scores of instrumental activities of daily living scale (IADL) Time: Baseline within 48 hours. 1, 3, and 12 months after ICU discharge.Description: Obtained by family interview and medical record
Measure: Rate of bed-bound status (%) Time: 1, 3, and 12 months after ICU discharge.Description: Obtained by family interview and medical record
Measure: Rate of mortality (%) Time: 1, 3, and 12 months after ICU discharge.Description: Measured by walked distance in 6 minutes(6MWT) in meter, range from 400 to 700 meters, higher value indicated better global health condition
Measure: Walking distance (m) by the 6 minute walk test Time: 3 and 12 months after ICU discharge.Alphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on December 13, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports