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There is one clinical trial.
Suicide is a major public health issue, and is the 9th leading cause of death overall. Suicidal thinking and behaviours have been linked to painful childhood experiences, stressors, and psychological trauma. Stressful experiences are also strongly linked to the development of a variety of mental health problems, including anxiety, depression and posttraumatic stress disorder. However, patients with suicidal ideas are often left out of trauma treatment, for fear that it will worsen their distress and increase their suicidal thinking. However, there is preliminary evidence that treating posttraumatic stress symptoms in patients with suicidal thoughts can lead to improvement in their symptoms and a reduction in suicidal thinking. For many individuals, overwhelming emotions and/or painful negative beliefs stemming from traumatic experiences contribute to a desire to escape though suicide or self-harm. Eye Movement Desensitization and Reprocessing (EMDR) is an evidence-based therapy for posttraumatic stress disorder that desensitizes painful memories, so that reminders in the present no longer provoke the overwhelming emotional responses. It has also been used for depression and a variety of other mental health problems. This study aims to test the safety and effectiveness of virtual/remotely delivered EMDR for adults with suicidal ideation. Patients will be randomly assigned to receive either EMDR therapy plus usual care or usual care alone. Symptoms of anxiety, depression, post-traumatic stress, distressing emotions, and suicidal thinking will be compared before and after therapy. For the EMDR group, side effects to EMDR will be tracked. The number of emergency room visits and hospitalizations will also be compared before and after therapy for each group.
Description: 21 item questionnaire on suicidal ideation and behaviour in past 1week. Score range 0 to 42, with higher scores worse in outcome.
Measure: Beck Scale for Suicide ideation (BSS) Time: BaselineDescription: 21 item questionnaire on suicidal ideation and behaviour in past 1week. Score range 0 to 42, with higher scores worse in outcome.
Measure: Beck Scale for Suicide ideation (BSS) Time: 1 day after EMDR completed (after 12 sessions completed) for EMDR groupDescription: 21 item questionnaire on suicidal ideation and behaviour in past 1week. Score range 0 to 42, with higher scores worse in outcome.
Measure: Beck Scale for Suicide ideation (BSS) Time: 3 months after enrollmentDescription: 6 questions on suicidal ideation. First Questions 3, 4, and 5 are answered only if Question 2 ("Have you actually had any thoughts of killing yourself") is answered as a yes. Questions 3 to 5 elaborate on suicidal ideation. Scored as "yes or no" for each question, as dichotomous variables.
Measure: Columbia Suicide Severity Rating Scale (CSSRS) Recent (self report of past 1 week) Time: BaselineDescription: 6 questions on suicidal ideation. First Questions 3, 4, and 5 are answered only if Question 2 ("Have you actually had any thoughts of killing yourself") is answered as a yes. Questions 3 to 5 elaborate on suicidal ideation. Scored as "yes or no" for each question, as dichotomous variables.
Measure: Columbia Suicide Severity Rating Scale (CSSRS) Recent (self report of past 1 week) Time: 1 day after EMDR completed (after 12 sessions completed) for EMDR groupDescription: 6 questions on suicidal ideation. First Questions 3, 4, and 5 are answered only if Question 2 ("Have you actually had any thoughts of killing yourself") is answered as a yes. Questions 3 to 5 elaborate on suicidal ideation. Scored as "yes or no" for each question, as dichotomous variables.
Measure: Columbia Suicide Severity Rating Scale (CSSRS) Recent (self report of past 1 week) Time: 3 months after enrolmentDescription: 10 questions about childhood adversity, which can be added. Score ranges from 0 to 10, with higher number indicating worse adversity before age 18.
Measure: ACES Questionnaire (ACES) Time: Baseline onlyDescription: 28 item scale, with score ranging from 0 to 100, with higher score indicating higher dissociative symptoms and severity.
Measure: DES II (Dissociative Experiences Scale II). Time: BaselineDescription: 28 item scale, with score ranging from 0 to 100, with higher score indicating higher dissociative symptoms and severity.
Measure: DES II (Dissociative Experiences Scale II). Time: 3 months after enrolment (study end).Description: 21 item questionnaire on depressive symptoms, score ranges from 0 to 63, with higher scores indicating worse depression.
Measure: BDI II (Beck Depression Inventory II) Time: BaselineDescription: 21 item questionnaire on depressive symptoms, score ranges from 0 to 63, with higher scores indicating worse depression.
Measure: BDI II (Beck Depression Inventory II) Time: 1 day after EMDR completed (after 12 sessions completed) for EMDR groupDescription: 21 item questionnaire on depressive symptoms, score ranges from 0 to 63, with higher scores indicating worse depression.
Measure: BDI II (Beck Depression Inventory II) Time: 3 months after enrollmentDescription: Nine item questionnaire on depressive symptoms, ranging from 0 (not at all) to 3 (nearly every day) for each item, scores range from 0 to 27 (worst symptoms). Then symptoms ranked as either Not difficult, somewhat difficult, Very difficult or Extremely difficult.
Measure: PHQ-9 (Patient Health Questionnaire 9). Time: BaselineDescription: Nine item questionnaire on depressive symptoms, ranging from 0 (not at all) to 3 (nearly every day) for each item, scores range from 0 to 27 (worst symptoms). Then symptoms ranked as either Not difficult, somewhat difficult, Very difficult or Extremely difficult.
Measure: PHQ-9 (Patient Health Questionnaire 9). Time: 1 day after EMDR completed (after 12 sessions completed) for EMDR groupDescription: Nine item questionnaire on depressive symptoms, ranging from 0 (not at all) to 3 (nearly every day) for each item, scores range from 0 to 27 (worst symptoms). Then symptoms ranked as either Not difficult, somewhat difficult, Very difficult or Extremely difficult.
Measure: PHQ-9 (Patient Health Questionnaire 9). Time: 3 months after enrollmentDescription: 7 Item questionnaire on anxiety symptoms, each ranked from 0 (not at all) to 3 (nearly every day), with a score ranging from 0 to 21. Higher scores indicate worse anxiety.
Measure: GAD 7 (Generalized Anxiety Disorder 7) Time: BaselineDescription: 7 Item questionnaire on anxiety symptoms, each ranked from 0 (not at all) to 3 (nearly every day), with a score ranging from 0 to 21. Higher scores indicate worse anxiety.
Measure: GAD 7 (Generalized Anxiety Disorder 7) Time: 1 day after EMDR completed (after 12 sessions completed) for EMDR groupDescription: 7 Item questionnaire on anxiety symptoms, each ranked from 0 (not at all) to 3 (nearly every day), with a score ranging from 0 to 21. Higher scores indicate worse anxiety.
Measure: GAD 7 (Generalized Anxiety Disorder 7) Time: 3 months after enrollmentDescription: 22 item questionnaire on traumatic or stressful events. Each item ranges from 0 (not at all) to 4 (extremely), with scores ranging from 0 to 88 (higher is more severe).
Measure: IES-R (Impact of Events Revised) Time: BaselineDescription: 22 item questionnaire on traumatic or stressful events. Each item ranges from 0 (not at all) to 4 (extremely), with scores ranging from 0 to 88 (higher is more severe).
Measure: IES-R (Impact of Events Revised) Time: 1 day after EMDR completed (after 12 sessions completed) for EMDR groupDescription: 22 item questionnaire on traumatic or stressful events. Each item ranges from 0 (not at all) to 4 (extremely), with scores ranging from 0 to 88 (higher is more severe).
Measure: IES-R (Impact of Events Revised) Time: 3 months after enrollmentDescription: 36 item questionnaire on emotion regulation, with each question ranked from 1 (almost never; 0-10% of the time) to 5 (almost always; 91-100% of the time). Scores range from 36 to 180, with higher scores indicating worse emotion regulation. Subscales indicate specific type of difficulties.
Measure: DERS (Difficulties in Emotion Regulation Scale) Time: BaselineDescription: 36 item questionnaire on emotion regulation, with each question ranked from 1 (almost never; 0-10% of the time) to 5 (almost always; 91-100% of the time). Scores range from 36 to 180, with higher scores indicating worse emotion regulation. Subscales indicate specific type of difficulties.
Measure: DERS (Difficulties in Emotion Regulation Scale) Time: 3 months after enrolmentDescription: Differences between the two arms with respect to number of emergency room visits and hospitalizations in the year before and after study.
Measure: Healthcare care utilization Time: 1 year before and one year after the study.Alphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on December 13, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports