SNPMiner Trials by Shray Alag
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N1325S (1) V773M (1) Q812R (1) G212A (1) A997T (1) S241T (1) E167K (1) G1764A (1) G80A (1) E62D (1) E274Q (1) M34T (1) G401S (1) A2142C (1) G211A (1) D76Y (1) G1631D (1) D76N (1) E384G (1) V249I (1) M1106C (1) L234I (1) A2143C (1) L101I (1) K806E (1) A687V (1) A119S (1) P1028S (1) A313G (1) D824V (1) S9C (1) C182A (1) S9G (1) S153F (1) S1900D (1) S1900C (1) R1644H (1) S1900A (1) T1456G (1) R702W (1) T1565C (1) E1021K (1) K15210D (1) G82S (1) G779C (1) G840A (1) G779F (1) V18M (1) A27L (1) L28M (1) T351I (1) K121Q (1) H180Q (1) L28P (1) G779S (1) M11T (1) M11Q (1) P549S (1) N215S (1) R352W (1) G60D (1) G84E (1) E161K (1) G951A (1) C23S (1) E184K (1) V1206L (1) Y842C (1) L432V (1) V736A (1) E89Q (1) R135W (1) Y253F (1) G843D (1) D820Y (1) F77L (1) S311C (1) D10W (1) G86R (1) Y143H (1) Y143C (1) R112H (1) Y143A (1) A227G (1) K101Q (1) R463C (1) G85E (1) L236P (1) A310V (1) T798M (1) S310Y (1) R222C (1) A4917G (1) T798I (1) E44D (1) L302P (1) Q30R (1) L786V (1) R287Q (1) P286R (1) D36Y (1) 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SNPMiner Trials (Home Page)
Report for Mutation A133S
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There is one clinical trial.
Clinical Trials
1 The Incidence, Inheritance, and Prognostic Significance of Polymorphisms in the RASSF1A Gene in Children With Wilms Tumors
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at DNA variations in the RASSF1A gene in young patients with Wilms' tumor.
NCT00088803 Conditions
- Kidney Cancer
Interventions
- Genetic: molecular genetic technique
- Genetic: polymerase chain reaction
- Genetic: polymorphism analysis
MeSH:Kidney Neoplasms Wilms Tumor
HPO:Nephroblastoma Renal neoplasm
Presence of the A133S polymorphism of the RASSF1A tumor suppressor gene in germline DNAs of children with Wilms' tumor. --- A133S ---
Inheritance pattern of the A133S polymorphism in the parents of children who carry this polymorphism. --- A133S ---
Differences in age at diagnosis, stage, histology, site of primary tumor, and outcome between patients with vs without the A133S polymorphism. --- A133S ---
DISEASE CHARACTERISTICS: - Diagnosis of Wilms' tumor OR - Control participants matched for race, sex, and age - No prior or concurrent history of cancer OR - Parents of children involved in the study PATIENT CHARACTERISTICS: - Not specified PRIOR CONCURRENT THERAPY: - Not specified DISEASE CHARACTERISTICS: - Diagnosis of Wilms' tumor OR - Control participants matched for race, sex, and age - No prior or concurrent history of cancer OR - Parents of children involved in the study PATIENT CHARACTERISTICS: - Not specified PRIOR CONCURRENT THERAPY: - Not specified Kidney Cancer Kidney Neoplasms Wilms Tumor OBJECTIVES: Primary - Determine the presence of the A133S polymorphism in the RASSF1A tumor suppressor gene by screening germline DNAs of children with Wilms' tumor. --- A133S ---
- Determine the inheritance pattern of the A133S polymorphism by evaluating the parents of children who carry this polymorphism. --- A133S ---
Secondary - Determine the differences in age at diagnosis, stage, histology, site of primary tumor, and outcome, between patients with vs without the A133S polymorphism. --- A133S ---
DNA is also analyzed from parents of patients with the A133S polymorphism. --- A133S ---
Primary Outcomes
Measure: Presence of the A133S polymorphism of the RASSF1A tumor suppressor gene in germline DNAs of children with Wilms' tumorMeasure: Inheritance pattern of the A133S polymorphism in the parents of children who carry this polymorphism
Secondary Outcomes
Measure: Differences in age at diagnosis, stage, histology, site of primary tumor, and outcome between patients with vs without the A133S polymorphismMeasure: Whether the S131F RASSF1A variant is a true polymorphism
Measure: Polymorphic differences in this gene based on ethnicity and sex