SNPMiner Trials by Shray Alag
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SNPMiner Trials (Home Page)
Report for Mutation K3048A
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There is one clinical trial.
Clinical Trials
1 Relation of Visceral Fat and Associated Cytokines With Early Cardiovascular Complications in Type 1 Diabetes: the VISCERA Study
Objective: To investigate whether visceral adipose tissue (VAT) and its adipokines contribute to early signs of cardiovascular disease, meaning coronary artery calcifications (CAC) and diastolic dysfunction in type 1 diabetes (T1DM). Research Design & Methods: A cross-sectional study of T1DM patients without a history of cardiovascular disease. CAC and VAT are measured using a CT scan. CAC is scored using the Agatston method. Echocardiography is performed to assess contractile abnormalities. Serum levels of adipocytokines (adiponectin, leptin, IL-6 and TNF-a) are measured using ELISA assays.
NCT02689570 Conditions
- Type 1 Diabetes
- Coronary Artery Calcifications
- Diastolic Dysfunction
Interventions
- Other: observational
MeSH:Diabetes Mellitus Diabetes Mellitus, Type 1 Calcinosis
HPO:Calcinosis Diabetes mellitus Type I diabetes mellitus
Plasma Serum levels of creatinin, total cholesterol, HDL cholesterol and triglycerides are measured on a Vitros 750 XRC (Ortho Clinical Diagnostic, Johnson & Johnson, Buckinghamshire, UK) Dimension Vista 1500 System (Siemens Healthcare Diagnostics, Huizingen, Belgium) with reagents from the same manufacturer (REF K1270A for creatinin, REF K1027 for total cholesterol, REF K3048A for HDL-cholesterol, REF K2069 for triglycerides). --- K1270A --- --- K3048A ---
Primary Outcomes
Description: A 64-slice non-contrast multidetector CT scan of the coronary arteries was performed to measure coronary artery calcifications (CAC) (Lightspeed, VCT; General Electric Medical Systems, Waukesha, Wis, Milwaukee, USA). Scoring was done by one skilled radiologist (R. Salgado), who was blinded to the subjects case files. Typical imaging parameters were: tube voltage 100 kv; current intensity 310 mA; rotation time 500 ms; and detector collimation 64 x 0.625 mm. Scan data were reconstructed at 75% of the cardiac cycle after the QRS complex. The radiation dose for calcium scoring ranged at 1.3-1.7 mSv. CAC was quantified (Agatston score) by means of a dedicated software application (SmartScore, AW). The Agatston score is the product of CAC area times the density.
Measure: coronary artery calcifications Time: once at the moment of inclusion of this cross-sectional, observational studySecondary Outcomes
Description: Standard 2-dimensional and Doppler Echocardiography (iE-33 Philips, The Netherlands) was performed by a single cardiologist blinded to the clinical status of the study participants. Briefly, left ventricular function was assessed by the parasternal long axis M-mode and modified biplane Simpson method. Diastolic function was determined taking into account all the following parameters: mitral inflow, pulmonary vein inflow signal and mitral annular tissue Doppler (tD) velocities from end expiratory cycles
Measure: diastolic dysfunction Time: once at the moment of inclusion of this cross-sectional, observational study