The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene encodes a lymphoid-specific phosphatase (LYP) which is an important downregulatory factor of T cell activation. A PTPN22 polymorphism, C1858T, was found associated with T1DM in different Caucasian populations. In this observational case-control study, we aimed at confirming the role of PTPN22, C1858T polymorphism in T1DM predisposition in a Greek population.

NCT01276743

Conditions

1. Type 1 Diabetes Mellitus

MeSH:Diabetes Mellitus Diabetes Mellitus, Type 1

HPO:Diabetes mellitus Type I diabetes mellitus

Study of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22) C1858T Polymorphism in Children and Adolescents of Greek Origin With Type 1 Diabetes Mellitus (T1DM). --- C1858T ---

Study of PTPN22 C1858T Polymorphism in Children and Adolescents of Greek Origin With T1DM The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene encodes a lymphoid-specific phosphatase (LYP) which is an important downregulatory factor of T cell activation. --- C1858T ---

A PTPN22 polymorphism, C1858T, was found associated with T1DM in different Caucasian populations. --- C1858T ---

In this observational case-control study, we aimed at confirming the role of PTPN22, C1858T polymorphism in T1DM predisposition in a Greek population. --- C1858T ---

• Difference of distribution of PTPN22 C1858T alleles between patients and controls of Greek origin. --- C1858T ---

• The association between PTPN22 C1858T polymorphism among patients and gender. --- C1858T ---

• The association between PTPN22 C1858T polymorphism among patients and age of onset of type 1 diabetes mellitus (T1DM). --- C1858T ---

• The association between the PTPN22 C1858T polymorphism among patients and presence of autoantibodies. --- C1858T ---