There is one clinical trial.
Neutrophil extracellular traps (NETs) and deoxyribonuclease (DNase) activity determine
outcome in ST elevation acute coronary syndrome (STE-ACS). DNase single nucleotide
polymorphisms (SNPs) were increased in a japanese cohort.
In the present study, the investigators seek to measure DNase SNPs frequency in a caucasian
STE-ACS cohort compared to healthy controls (each n=400). The investigators will compute
polymorphisms, DNase activity, NET surrogate markers and clinical variables in regression
models.
The single nucleotide polymorphism (SNP) Q222R in the DNase 1 gene, leading to impaired
extracellular DNase activity, was correlated with increased incidence of myocardial
infarction in Japanese patients(9). --- Q222R ---
Primary Outcomes
Measure: Frequency of SNPs of the DNase 1 and DNase gamma genes in the STE-ACS patient population compared to healthy controls Time: through study completion, an average of 2 years
Secondary Outcomes
Measure: Correlation of SNPs of the DNase 1 and gamma gene with DNase activity Time: through study completion, an average of 2 years
Measure: Correlation of SNPs with major adverse cardiac events Time: through study completion, an average of 2 years
Measure: Correlation of DNAse activity with major adverse cardiac events Time: through study completion, an average of 2 years
Measure: Correlation of SNPs with DNA-Histone complex levels Time: through study completion, an average of 2 years
Measure: Correlation of SNPs with MPO-DNA complex levels Time: through study completion, an average of 2 years
Measure: Correlation of SNPs with dsDNA levels Time: through study completion, an average of 2 years
Measure: Netosis quantification in STE-ACS patients and healthy controls Time: through study completion, an average of 2 years