SNPMiner Trials by Shray Alag
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SNPMiner Trials (Home Page)
Report for Mutation S100A
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There is one clinical trial.
Clinical Trials
1 Stopping Postpartum Vitamin A Supplementation: Are we Missing Concealed Benefit?
The purpose of this study is to evaluate the effect of post-partum maternal vitamin A supplementation on breast milk bioactive compounds and immune status, growth and morbidity of children in the first four months of life.
NCT02043223 Conditions
- Vitamin A Deficiency
Interventions
- Dietary Supplement: Vitamin A (<3-day postpartum)
- Dietary Supplement: Vitamin A (6 wk postpartum)
- Dietary Supplement: Vitamin A (<3-day and 6 wk postpartum)
- Dietary Supplement: Placebo
MeSH:Night Blindness Vitamin A Deficiency
HPO:Low levels of vitamin A Nyctalopia
human β-defensin-2 (HBD2); Neopterin; α-1-antitrypsin (AAT); neutrophil gelatinase-associated lipocalin (NGAL)-2 and S100A at two time points- 7 wk of age (1wk after 2nd dose of maternal supplementation , as well as, 1wk after first doses of pentavalent vaccination) 15 wk of age (1wk after three doses of pentavalent vaccination). --- S100A ---
Primary Outcomes
Description: immune regulators in breast milk e.g. B-cell activating factor (BAFF); IL-7; Lactoferrin; sCD14, sIgA and TGF-beta levels at three time points- < 3-day postpartum (before 1st dose of supplementation) 7 wk postpartum (1wk after 2nd dose of supplementation) 15 wk postpartum
Measure: Breast milk immune regulators Time: Four monthsSecondary Outcomes
Description: Mitogen stimulated whole blood IL-10, IL-13, IFN-gamma, IL-21 and IL-17 responses at two time points- 7 wk of age (1wk after 2nd dose of maternal supplementation , as well as, 1wk after first doses of pentavalent vaccination) 15 wk of age (1wk after three doses of pentavalent vaccination)
Measure: Infant T helper cell immune responses Time: Four monthsDescription: Tall like receptor (TLR)-4 and TLR9 agonist stimulated whole blood TNF-alpha and IL-10 and IFN-alpha responses at two time points- 7 wk of age (1wk after 2nd dose of maternal supplementation , as well as, 1wk after first doses of pentavalent vaccination) 15 wk of age (1wk after three doses of pentavalent vaccination)
Measure: Infant innate immune responses Time: Four monthsDescription: Hepatitis B and Tetanus Toxoid specific plasma cell IgG responses at 15 wk of age (1wk after three doses of pentavalent vaccination) And Hepatitis B and Tetanus Toxoid specific IgG in plasma and Polio (3 serotypes) specific secretory IgA (sIgA) in stool at two time points- 7 wk of age (1wk after 2nd dose of maternal supplementation , as well as, 1wk after first doses of pentavalent vaccination) 15 wk of age (1wk after three doses of pentavalent vaccination)
Measure: Infant vaccines (Hepatitis B, Tetanus and Oral polio) specific antibody responses Time: Four monthsDescription: Next generation sequencing (NGS) of bacterial 16s rDNA (+qPCR) in extracted stool samples and assessment of infant gut inflammatory markers e.g. human β-defensin-2 (HBD2); Neopterin; α-1-antitrypsin (AAT); neutrophil gelatinase-associated lipocalin (NGAL)-2 and S100A at two time points- 7 wk of age (1wk after 2nd dose of maternal supplementation , as well as, 1wk after first doses of pentavalent vaccination) 15 wk of age (1wk after three doses of pentavalent vaccination)
Measure: Relative abundance of infant gut microbial community and gut inflammatory markers Time: Four monthsOther Outcomes
Description: Infant plasma vitamin A status at 7 wk and 15 wk of age
Measure: Infant vitamin A status Time: Four monthsDescription: Infant Weight-for-Age z-score (WAZ) at 7 wk and 15 wk of age
Measure: Infant growth Time: Four monthsDescription: Infant morbidity status up to four months of age
Measure: Infant morbidity Time: Four monthsDescription: Plasma Retinol Binding Protein (RBP) and breast milk vitamin A level at two time points- < 3-day postpartum (before 1st dose of supplementation) 15 wk postpartum
Measure: Mother vitamin A status Time: Four months