Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
Name (Synonyms) | Correlation | |
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drug3958 | pregnant women with laboratory-confirmed 2019-n-CoV Wiki | 0.71 |
Name (Synonyms) | Correlation | |
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D014777 | Virus Diseases NIH | 0.11 |
D018352 | Coronavirus Infections NIH | 0.04 |
Name (Synonyms) | Correlation |
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Navigate: Correlations HPO
There is one clinical trial.
This is a substudy of NCT04333732. The goal of this sub-study is to identify and characterize biomarkers of trained immunity by measuring, in vitro, immune responses to heterologous products, especially viral associated products, in the MMR vaccinated and placebo groups. Participants in this sub-study will have two blood draws. One at baseline, prior to injection of the NCT04333732 study drug, and one around day 30 following injection of said study drug.
Description: Cytokines such as TNF-α, IL-1β and IL-6 produced by human monocytes, and IFN-γ produced by natural killer (NK)-cells, are markers of trained immunity and these (and other cytokines and chemokines) will be measured in supernatants of stimulated PBMCs from a cohort of participants in the CROWN CORONATION trial. All cytokines and chemokines are measured in picograms/milliliter.
Measure: Cytokine (or chemokine) production in response to heterologous stimuli Time: 30 daysDescription: Cytokines such as TNF-α, IL-1β and IL-6 produced by human monocytes, and IFN-γ produced by NK-cells, are markers of trained immunity and these (and other cytokines and chemokines) will be measured in supernatants of stimulated PBMCs from a cohort of participants in the CROWN CORONATION trial. All cytokines and chemokines are measured in picograms/milliliter.
Measure: The ratio of cytokine (or chemokine) production between day 30 and day 0 Time: 30 daysDescription: Cytokines such as TNF-α, IL-1β and IL-6 produced by human monocytes, and IFN-γ produced by NK-cells, are markers of trained immunity and these (and other cytokines and chemokines) will be measured in supernatants of stimulated PBMCs from a cohort of participants in the CROWN CORONATION trial. All cytokines and chemokines are measured in picograms/milliliter.
Measure: The ratio of cytokine (or chemokine) production between MMR and placebo Time: 30 daysAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on December 13, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports