|drug3076||Sodium Chloride 9mg/mL Wiki||0.58|
|drug2389||Patients with the treatment agains COVID19 Wiki||0.58|
There are 3 clinical trials
We aim to assess the benefits and harms of low-dose hydrocortisone in patients with COVID-19 and severe hypoxia.
Description: Days alive without life support (i.e. invasive mechanical ventilation, circulatory support or renal replacement therapy) from randomisation to day 28Measure: Days alive without life support at day 28 Time: Day 28 after randomisation
Description: Death from all causesMeasure: All-cause mortality at day 28 Time: Day 28 after randomisation
Description: Days alive without life support (i.e. invasive mechanical ventilation, circulatory support or renal replacement therapy) from randomisation to day 90Measure: Days alive without life support at day 90 Time: Day 90 after randomisation
Description: Death from all causesMeasure: All-cause mortality at day 90 Time: Day 90 after randomisation
Description: Defined as new episodes of septic shock, invasive fungal infection, clinically important GI bleeding or anaphylactic reactionMeasure: Number of participants with one or more serious adverse reactions Time: Day 14 after randomisation
Description: Number of days alive and out of hospital not limited to the index admissionMeasure: Days alive and out of hospital at day 90 Time: Day 90 after randomisation
Description: Death from all causesMeasure: All-cause mortality at 1 year after randomisation Time: 1 year after randomisation
Description: Assessed by EQ-5D-5LMeasure: Health-related quality of life at 1 year Time: 1 year after randomisation
Description: Assessed by EQ-VASMeasure: Health-related quality of life at 1 year Time: 1 year after randomisation
To date, there is no efficient therapeutics to prevent or treat COVID-19 related pulmonary failure. Corticosteroids (CS) could be a helpful therapeutic. Retrospective reports suggested survival improvement in patients with acute respiratory distress syndrome (ARDS). CT scan for COVID19 hospitalized patients showed sometimes unusual aspects of pneumonia, suggestive of an organizing phase of diffuse alveolar damage (DAD). We hypothesize that, in the context of alveolar aggression induced by COVID-19, CT scan could help to individualize patients with a high probability of pulmonary organizing process who could benefit from CS treatment.
Description: The 7-category ordinal scale is as follow: Not hospitalized with resumption of usual activities Not hospitalized, but unable to resume usual activities Hospitalized, not requiring O2 Hospitalized, requiring O2 from 1 to 5 l/min Hospitalized, requiring O2 >6 l/min, nasal high-flow O2, non-invasive mechanical ventilation, or both Hospitalized, requiring ECMO, invasive mechanical ventilation, or both Death.Measure: Clinical improvement defined by the improvement of 2 points on a 7-category ordinal scale, at 14 days. Time: 14 days
The objectives of this intermediate-size expanded access protocol are to assess the safety and efficacy of remestemcel-L in participants with MIS-C associated with COVID-19.
Data processed on December 13, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports