|D045169||Severe Acute Respiratory Syndrome NIH||0.04|
|D018352||Coronavirus Infections NIH||0.04|
There is one clinical trial.
COVID-19 patients with a severely symptomatic progression with development of an Acute respiratory distress syndrome (ARDS) due to SARS-CoV-2 need prolonged intensive care treatment involving pharmacological immobilization, sedation and mechanical ventilation, leaving them at a very high risk for developing Critical illness myopathy (CIM). CIM is associated with increased mortality and significant consequences for recovery and the ability to return to normal daily life. Up to date, there are no studies investigating the mid- or long-term course of the novel COVID-19 disease. The present study therefore aims to evaluate the clinical outcome of patients with ARDS due to SARS-CoV-2 with special attention to the development of CIM and its underlying causes. To provide the possibility of early diagnosis of CIM, critically ill patients will be regularly screened for muscle membrane alterations using (Muscle velocity recovery cycles) MRVC measurements. The primary endpoint is the incidence of CIM in patients with ARDS due to SARS-CoV-2, diagnosed according to the current diagnostic criteria.
Description: Short Form (36) Health Survey (SF-36)Measure: Short Form (36) Health Survey (SF-36) Time: 3 months
Description: MortalityMeasure: Mortality Time: 90 days
Description: Modified Rankin Scale (mRS); (0=no Symptoms at all, 6=dead)Measure: Modified Rankin Scale (mRS) Time: 90 days
Description: Duration of mechanical ventilation in daysMeasure: Duration of mechanical ventilation in days Time: 3 months
Description: Barthel Index (80-100= patient should be able to live independently, <20=total dependence)Measure: Barthel Index Time: 3 months
Description: Beck's Depression Inventory II (BDI-II)Measure: Beck's Depression Inventory II (BDI-II) Time: 3 months
Description: Essener Questionnaire for Coping with a Disease (EFK); (0=no burden of disease, 180-strong burden of disease)Measure: Essener Questionnaire for Coping with a Disease (EFK) Time: 3 months
Description: Number of patients with Critical Illness MyopathyMeasure: Number of patients with Critical Illness Myopathy Time: day 10
Data processed on December 13, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports