SNPMiner Trials by Shray Alag

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Report for SNP rs1906591

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials

1 Detection of Occult Paroxysmal Atrial Fibrillation in Cryptogenic Stroke Patients or TIA Using an Implantable Loop Recorder and Correlation With Genetic Markers.

Atrial fibrillation (AF) is the significant risk factor of ischemic stroke with incidence about 20% of all ischemic strokes. The undiagnosed AF in cryptogenic stroke patients could be present but not revealed by rutinne ECG.

NCT02216370 Cryptogenic Stroke or TIA Atrial Fibrillation
MeSH:Stroke Atrial Fibrillation
HPO:Atrial fibrillation Paroxysmal atrial fibrillation Stroke

Documented Atrial Fibrillation after episode of cryptogenic stroke / TIA Documented genetic mutation PITX2 chromosome 4q25, polymorphism rs1906591,rs10033464 and ZFHX3 chromosome 16q22, polymorphism rs2106261.

Primary Outcomes

Description: Documented Atrial Fibrillation after episode of cryptogenic stroke / TIA Documented genetic mutation PITX2 chromosome 4q25, polymorphism rs1906591,rs10033464 and ZFHX3 chromosome 16q22, polymorphism rs2106261

Measure: Documented Atrial Fibrillation after episode of cryptogenic stroke / TIA Documented genetic mutation PITX2 and ZFHX3

Time: 12 months

Secondary Outcomes

Measure: Time to documented Atrial Fibrillation Reccurent stroke or TIA Stroke Secondary Prevention Therapy changes within 12 months Neuroimaging Changes ( brain CT/ MRI)

Time: 12 months

Other Outcomes

Measure: Follow-up of patients with implanted ECG monitor REVEAL XT incidence of atrial fibrillation, stroke or TIA

Time: 3 Years

HPO Nodes

HP:0001297: Stroke
Genes 168
TRNF MAT2A GATA6 SON ACVRL1 MYH11 GLA CST3 COL3A1 PMM2 TGFB2 CYTB ND5 APP TRNV TRNS2 FOXE3 CALR ACVRL1 ACTB TPP2 GLA F2 GUCY1A1 MYBPC3 PIGA NR2F2 MYLK ELN APP TNXB TRNL1 GDF2 TRNL1 HBB WFS1 COX3 SH2B3 LIMK1 TBL2 PNP ENG TRNS1 TP53 SNAP29 PCNT JAK2 ZMPSTE24 GTF2I TRNF TRNW COX3 ZAP70 CPS1 CYP11B1 SMAD4 SMARCAL1 MYD88 JAG1 TREX1 KCNQ1 PRKAG2 MYH11 TRNH TGFB3 COX1 ANGPTL6 CCM2 OTC GNAQ ELN TRNW ND1 CYTB NOS3 ND5 MPL SMAD4 PRKCH ND4 DPM3 TREX1 COX2 LOX TGFBR2 RFT1 TRNQ PIK3C2A TRNS2 MECP2 NR3C1 MLXIPL APP ELN GUCY1A1 ADA2 ACTA2 CBS SLC2A10 APP COX1 CLIP2 ENG SLC19A2 HTRA1 FLNA PRKG1 HSD11B2 KRAS CST3 SCN5A GYS1 TGFBR1 BAZ1B COL4A1 APP ABCC6 LMNA FBN1 ND1 TRNQ F5 PRNP ACTG1 NPPA VHL MMUT HTRA1 STIM1 NAGS ACAD9 SMAD4 JAK2 COL3A1 TGFBR3 RFC2 SMAD3 SLC19A2 JAK2 GATA4 ND6 TTR ALOX5AP TRNS1 MPL ND6 NOTCH3 COX2 TANGO2 COL4A1 MYH11 TET2 DYRK1B AGXT TET2 ASS1 MFAP5 ADA2 XYLT1 TRNK XYLT2 MPL ENG GTF2IRD1 THPO MTHFR TRNC CRELD1
Protein Mutations 10
A143T C807T G20210A I843S L33P M235T N215S R112H V34L V66M
SNP 5
rs10033464 rs1906591 rs2106261 rs333 rs6265
HP:0004757: Paroxysmal atrial fibrillation
Genes 12
ABCC9 PRKAG2 TBX5 KCNJ2 CSRP3 KCNA5 KCNE2 MYL4 KCNJ5 SCN2B SCN5A SCN1B
Protein Mutations 18
A6986G A893S C1236T C3435T E161K E28A E28C E28D G2677T G389D G699A H558R M233I Q141K R14C S112A T117S T334G
SNP 15
rs10033464 rs1045642 rs1128503 rs13376333 rs17042171 rs17570669 rs1906591 rs2032582 rs2106261 rs2200733 rs2231142 rs2244613 rs3853445 rs6843082 rs776746