SNPMiner Trials by Shray Alag


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Report for SNP rs7993418

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD)

Age-Related Macular Degeneration (ARMD) is the most common cause of blindness in the adult population of the Western World. It affects the macula - the region of the retina most rich in photoreceptors and responsible for central vision. The ethiology of ARMD remains poorly understood. Population-based studies have demonstrated a complex ethiology, with contributions from a combination of genetic and environmental factors. Two major forms of ARMD are clinically distinguishable: the dry and wet form. The latter represents the more aggressive clinical subgroup, and is characterized by the abnormal growth of new blood vessels (neovascularization) under the macula, thus leading to the accumulation of fluid under the retina, bleeding, progression to fibrosis, and finally loss of central vision. The pathogenesis of this neovascularization is not fully understood, although the VEGF pathway is well known to be involved in angiogenesis and was implicated in the development of the new vessels under the macula. The VEGFs are the most specific and potent stimulators of the angiogenesis. Molecules that bind and inactivate the VEGF have been developed for the treatment of ARMD and they are applied in ARMD clinic through intra vitreal injections.The difference seen in response to anti VEGF treatment for ARMD between the patients is suggestive for the presence of factors influencing the effect of the drug. Some of these could be genetic variants within genes involved in ARMD pathogenesis or VEGF pathway. Few associations with markers within genes previously found to be related with the pathogenesis of ARMD have been found. It remains unknown whether variants involved in the anti VEGF treatment response could influence the therapeutic outcome. The purpose of this trial is to evaluate the association between a panel of selected polymorphic markers in the VEGF pathway and the response to therapy with anti VEGF antibody for ARMD. The hypothesis is that the individual genotype influences the response to the anti VEGF. This can lead to identification of genetic biomarkers allowing treatment individualization and optimization of the visual outcomes.

NCT02762188 Age-Related Macular Degeneration Device: Genotype analysis
MeSH:Macular Degeneration

A study demonstrated that the single nucleotide polymorphism (SNP) in VEGFR1 rs7993418 (TAC codon) form is associated to resistance to the anti VEGF therapy in carcinoma patients.

Primary Outcomes

Description: The visual acuity test is used to determine the smallest letters you can read on a standardized chart (Snellen chart).

Measure: Snellen visual acuity test result

Time: Baseline

Description: The visual acuity test is used to determine the smallest letters you can read on a standardized chart (Snellen chart).

Measure: Snellen visual acuity test result

Time: 3 months after treatment

Description: The visual acuity test is used to determine the smallest letters you can read on a standardized chart (Snellen chart).

Measure: Snellen visual acuity test result

Time: 6 months after treatment

Description: The visual acuity test is used to determine the smallest letters you can read on a standardized chart (Snellen chart).

Measure: Snellen visual acuity test result

Time: 12 months after treatment

Measure: Number of injections received per year

Time: 1 year

Description: Measured by optical coherence tomography (Heidelberg & Zeiss)

Measure: Central foveal thickness (µm)

Time: Baseline

Description: Measured by optical coherence tomography (Heidelberg & Zeiss)

Measure: Central foveal thickness (µm)

Time: 3 months after treatment

Description: Measured by optical coherence tomography (Heidelberg & Zeiss)

Measure: Central foveal thickness (µm)

Time: 6 months after treatment

Description: Measured by optical coherence tomography (Heidelberg & Zeiss)

Measure: Central foveal thickness (µm)

Time: 12 months after treatment

Description: Tested by optical coherence tomography (Heidelberg & Zeiss)

Measure: Presence of Intra Retinal Cysts (yes/no)

Time: Baseline

Description: Tested by optical coherence tomography (Heidelberg & Zeiss)

Measure: Presence of Intra Retinal Cysts (yes/no)

Time: 3 months after treatment

Description: Tested by optical coherence tomography (Heidelberg & Zeiss)

Measure: Presence of Intra Retinal Cysts (yes/no)

Time: 4 months after treatment

Description: Tested by optical coherence tomography (Heidelberg & Zeiss)

Measure: Presence of Subretinal Fluid (yes/no)

Time: Baseline

Description: Tested by optical coherence tomography (Heidelberg & Zeiss)

Measure: Presence of Subretinal Fluid (yes/no)

Time: 3 months after treatment

Description: Tested by optical coherence tomography (Heidelberg & Zeiss)

Measure: Presence of Subretinal Fluid (yes/no)

Time: 4 months after treatment

Description: Tested by optical coherence tomography (Heidelberg & Zeiss)

Measure: Presence of Pigment Epithelial Detachment (yes/no)

Time: Baseline

Description: Tested by optical coherence tomography (Heidelberg & Zeiss)

Measure: Presence of Pigment Epithelial Detachment (yes/no)

Time: 3 months after treatment

Description: Tested by optical coherence tomography (Heidelberg & Zeiss)

Measure: Presence of Pigment Epithelial Detachment (yes/no)

Time: 4 months after treatment


HPO Nodes