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D000435: Alcoholic Intoxication

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (6)


Name (Synonyms) Correlation
drug3194 Pitolisant Wiki 0.71
drug4835 attendance by ambulance crew Wiki 0.71
drug490 BCG-Denmark Wiki 0.41
Name (Synonyms) Correlation
drug487 BCG vaccine Wiki 0.35
drug3844 Saline Wiki 0.21
drug3195 Placebo Wiki 0.06

Correlated MeSH Terms (3)


Name (Synonyms) Correlation
D000428 Alcohol Drinking NIH 0.50
D000437 Alcoholism NIH 0.25
D004630 Emergencies NIH 0.12

Correlated HPO Terms (0)


Name (Synonyms) Correlation

Clinical Trials

Navigate: Correlations   HPO

There are 2 clinical trials


1 Ambulance Calls for Substance Use and Alcohol in a Pandemic (ASAP): Exploring Attendance at Incidents Involving Substance and/or Alcohol Use During COVID-19 Pandemic

The Primary objective is to explore ambulance service attendance at incidents involving alcohol and/or substance use over the period of the pandemic lockdown, and the following months. This will be to determine prevalence and explore factors such as patient gender, age, ethnicity or location. Analysis will examine the calls over the course of the year prior to the lockdown, and then compare this to the period of lockdown and following months.

NCT04474444
Conditions
  1. Alcohol Use, Unspecified
  2. Substance Use
  3. Intoxication Alcohol
  4. Emergencies
  5. COVID-19 Pandemic
  6. Treatment
Interventions
  1. Other: attendance by ambulance crew
MeSH:Emergencies Alcoholic Intoxication Alcohol Drinking

Primary Outcomes

Description: Counts of attendances for alcohol and drug use by the East Midland's Ambulance Service over the time period. This will be a number per day of people attended.

Measure: Attendances for alcohol and drug use

Time: Full data set 23/03/2019 compared to 22/03/2021 to look at interruption (lockdown) in the time series.
2 The Effects of the Histamine-3 Receptor Inverse Agonist Pitolisant on Alcohol Self-Administration in Heavy Drinkers

This is a double-blind, randomized, placebo-controlled, crossover design trial that will test the effect of pitolisant on alcohol self-administration and craving following a priming dose of alcohol. The specific objective of this proposal is to determine whether pitolisant has effects on alcohol consumption and craving

NCT04596267
Conditions
  1. Alcohol Use Disorder
  2. Alcohol Drinking
Interventions
  1. Drug: Pitolisant
  2. Drug: Placebo
MeSH:Alcoholism Alcoholic Intoxication Alcohol Drinking

Primary Outcomes

Description: Alcohol consumption will be measured by using a graduated cylinder to determine the amount of alcohol given to the subject that was not consumed. This outcome will be measured as standard drink units. A standard drink contains approximately 0.6 fluid ounces of pure alcohol.

Measure: Alcohol Consumption

Time: 2.6 hours

Description: Alcohol craving will be measured by self report with the Visual Analog Scale (VAS). The VAS is a straight line with one end meaning no alcohol craving and the other end meaning intense alcohol craving. The Participant marks a point on the line that matches their amount of alcohol craving.

Measure: Alcohol Craving

Time: 2.6 hours

Description: The Alcohol Urge questionnaire (AUQ) is an 8 item measure of self-reported urges to drink in human laboratory studies that assesses the participant's urge for an alcoholic drink at the time the questionnaire is completed, Questions are in the form of a 7-point Likert scale (from strongly disagree to strongly disagree) and participants select the extent to which they disagree or agree with the 8 statements relating to desire to drink, expectation of a desired outcome from drinking, and inability to avoid drinking if alcohol was available. Lower scores are associated with less urge for an alcoholic drink.

Measure: Alcohol Urge

Time: 2.6 hours

Secondary Outcomes

Description: Whether pitolisant increases the stimulant effects of a priming drink of alcohol will be assessed using the Biphasic Alcohol Effects Scale (BAES). It is a self-report, unipolar adjective rating scale that is designed to measure both stimulant and sedative effects of alcohol. It consists of fourteen items, that comprise two subscales (stimulant and sedative). Items are rated on a eleven-point scale from 0 (not at all) to 10 (extremely). The stimulant subscale can range from 0 to 70 and the sedative scale can rage from 0 to 50. Higher scores are associated with more stimulant and sedative effects, respectively.

Measure: Alcohol-induced stimulation

Time: 2.6 hours

Description: The Visual Analog Scale (VAS) will be used to assess alcohol craving during the medication exposure period. The VAS is a 10 cm straight line with one end meaning no alcohol craving and the other end meaning intense alcohol craving. Higher scores are associated with more cravings.

Measure: Alcohol craving during 4-day drug exposure

Time: 4 days

Description: Alcohol consumption during the 4 days of drug exposure will be measured using the timeline followback method

Measure: Alcohol consumption during the 4-day drug exposure

Time: 4 days

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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