Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
Navigate: Correlations HPO
There is one clinical trial.
This study aims to evaluate the relative efficacy of biofeedback and traditional treatment for residual speech errors when both are delivered via telepractice. In a single-case randomization design, up to eight children with RSE will receive both visual-acoustic biofeedback and traditional treatment via telepractice. Acoustic measures of within-session change will be compared across sessions randomly assigned to each condition. It is hypothesized that participants will exhibit a clinically significant overall treatment response and that short-term measures of change will indicate that biofeedback is associated with larger increments of progress than traditional treatment.
Description: Probes of words and syllables containing /r/ in various phonetic contexts will be elicited at the start and end of treatment. We follow a semi-automated protocol to demarcate intervals of interest in a Praat textgrid. Textgrids and recordings are submitted to a forced aligner, followed by automated extraction of formant frequencies (F1, F2, F3) at the center of each /r/ interval identified. F3-F2 distance, which is smaller in correct /r/, serves as the primary acoustic correlate of accuracy.
Measure: Acoustically measured accuracy of /r/ in words Time: Immediately before each of 20 treatment sessions over 10 weeksDescription: Probes of words and syllables containing /r/ in various phonetic contexts will be elicited at the start and end of treatment. We follow a semi-automated protocol to demarcate intervals of interest in a Praat textgrid. Textgrids and recordings are submitted to a forced aligner, followed by automated extraction of formant frequencies (F1, F2, F3) at the center of each /r/ interval identified. F3-F2 distance, which is smaller in correct /r/, serves as the primary acoustic correlate of accuracy.
Measure: Acoustically measured accuracy of /r/ in words Time: Immediately after each of 20 treatment sessions over 10 weeksDescription: Probes of words and syllables containing /r/ in various phonetic contexts will be elicited at the start and end of treatment. We follow a semi-automated protocol to demarcate intervals of interest in a Praat textgrid. Textgrids and recordings are submitted to a forced aligner, followed by automated extraction of formant frequencies (F1, F2, F3) at the center of each /r/ interval identified. F3-F2 distance, which is smaller in correct /r/, serves as the primary acoustic correlate of accuracy.
Measure: Acoustically measured accuracy of /r/ in words Time: In three separate sessions within two weeks of the start of all treatmentDescription: Probes of words and syllables containing /r/ in various phonetic contexts were elicited at the start and end of treatment. We follow a semi-automated protocol to demarcate intervals of interest in a Praat textgrid. Textgrids and recordings are submitted to a forced aligner, followed by automated extraction of formant frequencies (F1, F2, F3) at the center of each /r/ interval identified. F3-F2 distance, which is smaller in correct /r/, serves as the primary acoustic correlate of accuracy.
Measure: Acoustically measured accuracy of /r/ in words Time: In three separate sessions within two weeks after the end of all treatmentDescription: To assess generalization of treatment gains to untreated words, participants will read probe lists eliciting /r/ in various phonetic contexts. Stimuli in each probe will be presented individually in randomized order. No auditory models will be provided; for children with reading difficulty, semantic cues will be provided to elicit the intended word. Individual words will be isolated from the audio record of each word probe and presented in randomized order for binary rating (correct/incorrect) by naive listeners who are blind to treatment condition and time point (but will see the written representation of each target word). We will use the proportion of "correct" ratings for each token as our primary measure of perceptually rated accuracy.
Measure: Proportion of "correct" (vs "incorrect") ratings by blinded naive listeners, a measure of perceptually rated accuracy of /r/ production, for /r/ sounds produced in word or syllable probes. Time: In three separate sessions within two weeks of the start of all treatmentDescription: To assess generalization of treatment gains to untreated words, participants will read probe lists eliciting /r/ in various phonetic contexts. Stimuli in each probe will be presented individually in randomized order. No auditory models will be provided; for children with reading difficulty, semantic cues will be provided to elicit the intended word. Individual words will be isolated from the audio record of each word probe and presented in randomized order for binary rating (correct/incorrect) by naive listeners who are blind to treatment condition and time point (but will see the written representation of each target word). We will use the proportion of "correct" ratings for each token as our primary measure of perceptually rated accuracy.
Measure: Proportion of "correct" (vs "incorrect") ratings by blinded naive listeners, a measure of perceptually rated accuracy of /r/ production, for /r/ sounds produced in word or syllable probes. Time: In three separate sessions within two weeks after the end of all treatmentAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on December 13, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports