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D007410: Intestinal Diseases

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (6)


Name (Synonyms) Correlation
drug4260 TD-1473 [Tablet A] Wiki 0.50
drug1415 ELISA Wiki 0.50
drug4611 VIR-7831 Wiki 0.50
Name (Synonyms) Correlation
drug4261 TD-1473 [Tablet B] Wiki 0.50
drug3551 RT-PCR Wiki 0.29
drug3195 Placebo Wiki 0.02

Correlated MeSH Terms (6)


Name (Synonyms) Correlation
D015212 Inflammatory Bowel Diseases NIH 0.67
D003092 Colitis NIH 0.15
D003093 Colitis, Ulcerative NIH 0.14
Name (Synonyms) Correlation
D003424 Crohn Disease NIH 0.13
D045169 Severe Acute Respiratory Syndrome NIH 0.02
D018352 Coronavirus Infections NIH 0.02

Correlated HPO Terms (5)


Name (Synonyms) Correlation
HP:0002242 Abnormal intestine morphology HPO 1.00
HP:0002037 Inflammation of the large intestine HPO 0.67
HP:0002583 Colitis HPO 0.15
Name (Synonyms) Correlation
HP:0100279 Ulcerative colitis HPO 0.14
HP:0100280 Crohn's disease HPO 0.13

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials


1 Assessing the Drug Exposure Risk of Infants Breastfed by Women With Inflammatory Bowel Disease

Breastfeeding is beneficial to both mother and baby. However, many breastfeeding women are affected by long-term health conditions and need to take medications. Sometimes, concerns about transfer of drugs to infants via breast milk lead the mothers to either avoid breastfeeding or stop their medication. Inflammatory Bowel Disease (IBD) is a chronic condition that is marked by an abnormal response of the body's immune system, and high levels of certain proteins that cause inflammation (Cytokines like Tumor Necrosis Factor-alpha or TNFα). A group of drugs called "biologics" target and stop these proteins from causing inflammation, and have been successfully used to treat this condition. Inflammatory proteins may be present in breast milk of healthy women in variable levels, and may play a role in development of infant's brain and immune system. This study is being conducted to investigate: - Concentration of some of the inflammatory proteins in breast milk of mothers with IBD and healthy controls - Interaction between these proteins and biologics in breast milk of women with IBD - Potential role of these proteins (and their interaction with biologics) on development of infant learning and memory function It has been presumed that concentrations of TNFα and some other cytokines are higher in breast milk of women with IBD, and the biologics can normalize these high levels. Due to precautions for COVID-19, the study now consists of only two mandatory study visits and two optional study visits. The mandatory visits include two home visits in the first 4 months postpartum to complete a participant questionnaire and collect a small sample of breast milk at each visit. The optional study visits consist of two visits at the Hospital for Sick Children for evaluation of learning and memory function of the infant at the ages of 12 and 18 months. Additionally, mothers will be required to complete for their infant subscales of The Ages and Stages Questionnaires®, Third Edition (ASQ®-3) either in person or over the telephone at the ages of 12 months and 18 months.

NCT03397108
Conditions
  1. Crohn's Disease
  2. Ulcerative Colitis
  3. Healthy Controls
MeSH:Crohn Disease Colitis Colitis, Ulcerative Intestinal Diseases Inflammatory Bowel Diseases
HPO:Abnormal intestine morphology Colitis Crohn's disease Inflammation of the large intestine Ulcerative colitis

Primary Outcomes

Description: Multiplex assay will be used to measure TNFα and downstream chemokines including CCL2, CCL4, CCL7, CXCL10 in breast milk of two groups of participants (women with IBD and healthy controls). (The unit of measurement is the same for all these cytokines)

Measure: Levels of TNFα and its downstream chemokines (CCL2, CCL4, CCL7, and CXCL10) in breast milk of women with IBD and healthy controls by Multiplex assay

Time: 4 years

Secondary Outcomes

Description: ELISA assay will be used to measure total and free drug levels (bound and unbound to TNFα) in breast milk of lactating women with IBD. (The unit of measurement is the same for infliximab and adalimumab).

Measure: Milk concentration of TNFα inhibitors (infliximab, adalimumab) at different time-points between two doses of medication, in lactating women with IBD by ELISA assay

Time: 4 years

Description: The infants of women with IBD and healthy controls will be examined for cognitive development using Bayley-III

Measure: Scores on cognitive subset of Bayley Scales of Infant and Toddler development- Third Version (Bayley-III) in infants of healthy controls and women with IBD

Time: 4 years

Description: Infants of healthy controls and women with IBD will be examined for communication and problem-solving development using the ASQ®-3. This supplementary measure is intended to provide additional data as an alternative to Bayley test under unprecedented circumstances which preclude participants to complete Bayley test at the Hospital for Sick Children

Measure: Scores on the "Problem-solving" and "Communication" subscales of The Ages and Stages Questionnaire (ASQ®-3) in infants of healthy controls and women with IBD

Time: 4 years

Description: An estimation of the population distribution of anti-TNFα antibodies (infliximab and adalimumab) in breast milk of women with IBD will be made, using population pharmacokinetic modelling

Measure: Simulated/predicted profiles of TNFα inhibitors (infliximab, adalimumab) in breast milk in a large population of lactating women with IBD by population pharmacokinetic modelling

Time: 4 years
2 PREPARE-IBD: Physician Responses to Disease Flares and Patient Adaptation in Relation to Events in Inflammatory Bowel Disease During COVID-19 Pandemic

To find out what adaptations have been made by Inflammatory bowel disease physicians and patients in relation to therapies in flaring IBD patients during severe acute respiratory syndrome 2-COV and what the impact of these is on IBD patients with no symptomatic COVID-19 and in suspected/confirmed COVID-19. Also whether there any IBD related factors impacting the outcome of patients with COVID-19 symptoms or COVID-19 disease

NCT04410484
Conditions
  1. Inflammatory Bowel Diseases
  2. Coronavirus Infection
MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome Intestinal Diseases Inflammatory Bowel Diseases
HPO:Abnormal intestine morphology Inflammation of the large intestine

Primary Outcomes

Measure: Flare of IBD needing change in therapy or surgery

Time: 3 months
3 SARS-CoV-2 Infection in Patients From Two Tertiary Inflammatory Bowel Disease (IBD) Centres: Frequency of Suspected and Confirmed Infections, Severity and Outcome Management

Most of the inflammatory bowel disease (IBD: Crohn's disease and ulcerative colitis) in a tertiary expert Centre are on immunosuppressive and/or biological therapy. Theoretically, these treatments may increase patients' risk of infection, in particular viral infection. Therefore, the current SARS-Cov-2 pandemia, with its unprecedent worldwide morbidity and mortality, may have a negative impact on IBD patients' clinical course. Identifying an increased risk in this particular patients' population as well as the risk/protective factors is of outstanding importance, in order to adapt their treatment and surveillance. As a consequence, our aims were (i) to measure retrospectively the risk of SARS-CoV-2 (proven by biological testing or suspected due to record of potential clinical symptoms of COVID-19 infection) in this patients' cohort (principal objective), (ii) to identify risk or protective factors for SARS-CoV-2 infection in IBD, and (iii) to analyze the outcome of patients in case of suspected or confirmed COVID-19. The results of this study may be important to adjust our surveillance and therapeutic strategy in these patients, in particular if high virus circulation will occur in the future.

NCT04492267
Conditions
  1. Inflammatory Bowel Disease
MeSH:Intestinal Diseases Inflammatory Bowel Diseases
HPO:Abnormal intestine morphology Inflammation of the large intestine

Primary Outcomes

Measure: Retrospective analysis of severity and specific needs in case of SARS-CoV-2 infection in IBD patients

Time: Files analysed retrospectily from March 1st, 2020 to July 31, 2020 will be examined
4 A Phase 1, Two-Part, Open-Label Study to Assess the Relative Bioavailability of Two TD-1473 Tablet Formulations Under Fasted and Fed Conditions in Healthy Subjects and the Pharmacokinetics of TD-1473 in Healthy Chinese Subjects

This is a Phase 1, 2-part, open-label study. Part A will be a formulation bridging and food effect study in healthy adult subjects. Part B will be an assessment of pharmacokinetics (PK) in healthy adult Chinese subjects.

NCT04587713
Conditions
  1. Intestinal Disorder
  2. Bowel Diseases, Inflammatory
Interventions
  1. Drug: TD-1473 [Tablet A]
  2. Drug: TD-1473 [Tablet B]
MeSH:Intestinal Diseases Inflammatory Bowel Diseases
HPO:Abnormal intestine morphology Inflammation of the large intestine

Primary Outcomes

Description: Area under the concentration-time curve, from time 0 to the last observed non-zero concentration (AUC0-t) of TD-1473 in Plasma

Measure: AUC0-t

Time: Predose and at prespecified time points up to 5 days after dosing on Day 1 of each period

Description: Area under the concentration-time curve, from time 0 extrapolated to infinity (AUC0-inf) of TD-1473 in Plasma

Measure: AUC0-inf

Time: Predose and at prespecified time points up to 5 days after dosing on Day 1 of each period

Description: Maximum observed concentration (Cmax) of TD-1473 in Plasma

Measure: Cmax

Time: Predose and at prespecified time points up to 5 days after dosing on Day 1 of each period

Secondary Outcomes

Description: Number and severity of treatment emergent adverse events.

Measure: Adverse events

Time: Day 1 through Day 7 of each period

HPO Nodes


HP:0002242: Abnormal intestine morphology
Genes 1004
KMT2D SH2B1 RPS7 UBR1 DNAAF1 MITF GTF2IRD1 CAVIN1 SLC9A7 CTRC FRMPD4 SPINK5 APC PGAP2 ARVCF FANCM RPS15A RELA EDN3 RSPH9 NOTCH2 FCN3 RREB1 NAA10 HPGD PMS1 NPHP3 TCF4 POLG SHPK RFX6 PRSS1 HLA-DPA1 PEX11B CFC1 DNAH11 GJB6 POLG STK11 CDC45 GPC1 BUB1B DMD CYP27A1 SNAI2 WAS TJP2 CFAP221 MTTP MCC GJB2 AP1S1 CEP290 TTC7A BRIP1 HSD3B7 SEC24C CDK8 DDX59 BMPR1A PIK3CA B3GALT6 TWNK COL3A1 SATB2 CYBA FANCG FOXF1 HLA-DPB1 WAC KIT CLCN4 ENPP1 AKT1 TNPO3 XRCC4 NIPBL SIN3A FLNB ITGA8 PTRH2 EFEMP2 MYCN IL10RA ECE1 SLC9A3 TRNW CTLA4 ADAMTS3 SOX10 PRKCD SUFU HLA-B COL5A1 CCR6 AHI1 BLM CFAP300 AKR1D1 ADA2 VPS51 COL5A1 PEX19 USB1 MUTYH FAH MSH2 F12 NEK1 LIG4 POLE DNMT3B RPL35 FANCL NDUFB11 CPLX1 FAS FAN1 RFX5 SEMA3D FTSJ1 MYRF PIK3CA ODAD4 CCDC40 SPINT2 SRP54 MSH2 TINF2 CAV1 SDHC MKS1 VANGL1 CFTR FOXE1 CCBE1 AGA KMT2A FANCF MMP21 GDNF ASCL1 GATA6 ND4 RPS19 FLI1 STAT1 MBTPS2 SALL4 BMPR1A L1CAM SOX10 LONP1 L1CAM BTK MSH6 NOTCH3 CXCR4 RSPH1 MEFV CCBE1 RET PALLD SMAD4 SMAD4 SKIV2L STAT1 ISL1 HMBS ALG3 SNAI2 TCOF1 FOXJ1 FANCI NRAS CREBBP PEX6 NOTCH2 CFAP298 SALL4 PORCN CEP57 FGFR1 RAD21 PIGV SMAD7 CLMP DOK7 FGF8 SBDS RET RERE FLNA TCTN3 PTPN22 DACT1 SLC6A8 TTC7A TRNS2 CDON EDNRB FGF20 C1R MMEL1 RASGRP1 FANCA DMP1 TTC12 RPS19 IL12A-AS1 KLLN PPP1R12A TYMP CDKN1B GAS1 TGFB1 CCN2 MAP3K7 HYLS1 NPM1 GAS2L2 CTLA4 IL12A CNKSR2 PTPRJ APC IRF5 SAR1B GDNF DSE USP9X DHODH RPGR NSUN2 JAK3 PDGFRA FERMT1 DNAJC21 MSH2 DNAL1 NCF4 MPI MYCN RHBDF2 DDX59 TGFB1 MKS1 EXOC6B RPS26 EWSR1 SLC39A4 FLNA SMO RNF43 MNX1 RPGRIP1L FBN2 ASCL1 APC SLC29A3 BAX ABCB1 PEX10 MSH3 JAK1 RET PGM3 DNAJB13 JMJD1C TP53 BUB1 PALB2 TRNK SDHC ZEB2 EDN3 TMEM237 TBX1 ZAP70 ATRX NCF4 COX4I2 ODAD2 PEX12 HCCS B2M ENG DNAI1 MCM6 MDM2 MADD CEP104 FANCC AXIN2 LIMK1 MED12 AMACR PIGL HMGA2 ZBTB24 PCSK1 APC NCF1 EP300 IL2RB NRTN CDKN2A SAA1 EP300 PMS1 RPS10 PLCG2 BRCA2 POLG TTC37 PIGO LTBP4 ACOX2 IGLL1 SLC6A19 ODAD3 PERCC1 SYP BRCA2 PTCH1 HNRNPK EDNRB IGHM PDGFRB FASLG SOX10 MUSK EPCAM APC TMEM216 CISD2 GDF2 BUB1B CYBB RAD54B MLH1 EDN3 SLC6A8 PLG AURKA GPIHBP1 FLCN TYMP COX3 CD3G COG8 PIGV USF3 ACVRL1 CYBB MTTP SERPING1 LPIN2 NTHL1 SETBP1 ITGA6 STRA6 FANCB STAT3 CPLANE1 GLI2 SLX4 DNMT3B RECQL4 SLC2A2 RPL31 MYO1H LEMD3 HMBS GABRD SEMA4A TRMT5 PALB2 ASXL1 NEK10 CCDC22 DMPK DCC RPL5 MKS1 RPS27 PTCH1 TFAP2A RPS24 RPL35A UFD1 ARL13B AHI1 UBE2T SRP54 MEFV RTEL1 DNAAF2 KDM3B SF3B4 ACTG2 EIF2AK3 ABCB4 ARL6 PEX12 BDNF AP1S1 MYOD1 HNRNPK PIGY SALL1 HELLS IDS ZEB2 PIGO POLE SMC1A EYA1 RNF43 PIBF1 SETD2 ERCC4 SIX3 OCRL DZIP1L NEUROG3 CENPF PAX3 PDGFRL SMC3 POU2AF1 ARPC1B GATA1 POLG RAPSN TSR2 HLA-DRB1 PHOX2B DLC1 CEP41 BMPR1A HDAC8 MLH3 CHD7 POLR1C EFL1 TERC BUB3 RAD51C RBM10 MASP2 TRIP13 CC2D2A BMPR1A FGFR2 AIRE PARN HSD3B7 RFWD3 DNAAF6 OPLAH SDHD WFS1 GDNF NHP2 NOD2 ERGIC1 COMT ZMYND10 BLNK PLA2G4A KRAS MSH6 EDNRB KAT6A ARX SDHB COL5A2 TP53 WT1 LIPA SDHC RPS6KA3 SMAD4 KDM6A SALL1 SERPING1 SEMA3C EDN3 TMEM67 PIGN MYLK DNAH1 POLD1 UBR1 NODAL ND6 PIEZO1 IRGM ALG13 LRRC56 COL1A1 DHCR7 AGTR2 MPI FREM1 ZNF711 F13B INSR BMPR1A LBR BBS1 SDHD ASXL1 ARID1B KIT FGFR1 ARL3 RET RRM2B SETD5 CDKN2A SHH JAK3 PIK3C2A CFTR AMACR GATA1 CTBP1 MYO5B CEP120 MCIDAS ARX PTEN MYC FGFR2 TP53 CTNNB1 BCOR RAD51C SUFU DLL1 RAB39B PEX13 B3GLCT TGFBR2 CLIP2 CYBC1 ELN RET ALDH18A1 GDNF HIRA GP1BB DRC1 TP53 DIS3L2 IRF5 ARMC9 MEN1 ZMPSTE24 COX1 CEP41 CSPP1 CCNQ PTF1A ELN MYD88 SPAG1 BUB1 PORCN PHOX2B PMS2 FOXP3 SOX10 RPL27 SEC23B POLG CBL POLA1 PKHD1 MITF AXIN2 EDN3 PPOX MIR17HG TCF3 GDI1 RPL11 GREM1 CHEK2 PTCHD1 STXBP2 CREBBP STK36 DOCK8 STK11 PEX2 TTC37 DACT1 SMAD4 EDNRB POLR1D TDGF1 KRAS GLA AP1B1 PHOX2B LRRC6 RPL15 INPP5E FANCD2 FAT4 MLH3 CHST14 CIITA KIT BACH2 DNAJC21 MUTYH PEX26 IL12RB1 CCNO IL21 HYDIN IL2RA KIT CTC1 TSPAN7 C12ORF65 BAAT PRTN3 KIT FRAS1 LIG4 MYCN TRNS1 TRNH AAGAB TTC7A INPP5E KATNIP SALL4 SI SKIV2L ZAP70 MNX1 ZNF81 BRCA1 RPS6KA3 SLC7A7 FGFRL1 RARB RMRP GATA6 ND1 ADAMTS3 LIPA PEX3 CASP10 PAK3 ZEB2 C4A RPL18 TRNQ KIAA0586 LBR SBDS DNAI2 LMOD1 CYP7B1 PDGFRA PEX1 CHRM3 NUP88 TRNE TLR2 SERPING1 TNFAIP3 ELN PTCH2 DNAH9 MSH2 ASXL1 DHCR7 F5 KITLG SDHB AMER1 NCF2 MKKS PIK3CA FOXP3 PKD1 CEP57 TNFSF15 AKT1 ZFPM2 APC SDHA TRNF WNT2B CEP120 XIAP MLH1 ODC1 PIGW ACSL4 ACTG2 FOXH1 KLHL7 MID2 LRRC8A RPL26 RMRP PTEN PTPN12 TBCE TCF4 MLH3 FBLN5 DISP1 TCTN2 MSH6 ACTA2 PEX14 GAS8 PEX16 DGAT1 NIPBL HABP2 RPS28 RAC2 SLCO2A1 SDHB C12ORF65 DNAAF3 CLMP LRP2 ZIC2 SRP54 PLVAP DYRK1A RPS20 RAD21 COL14A1 CDKN2C MED12 AXIN2 CCDC47 CPOX IL1RAPL1 RPS17 ITCH APC2 KIF7 ITGB4 ENG ZNF423 LCT SPIB TP63 NSD1 SPEF2 IL6 CREBBP TMEM237 HYOU1 TMEM231 TBX1 EPCAM JAK2 MECP2 ATP8B1 PGAP3 PRSS2 TBL2 IL10 MLH1 AKR1D1 ABL1 FANCE WIPF1 NCF2 GUCY2C MTOR RFC2 PSTPIP1 NPHP3 PNLIP NSD2 SALL4 CCDC103 OFD1 DNAAF5 GATA6 IL12A EDNRB LMNA EPCAM SOX10 EDN3 BRCA1 STAG2 EP300 SRCAP CDKN2B DCTN4 CLCA4 SIX1 FCGR2A MST1 TGIF1 DNAH5 MBTPS2 SEMA3E TCTN1 SRSF2 SLC18A3 ZNF41 ALG8 CD79A PIK3R1 HNRNPU NOP10 POLD1 CCND1 STEEP1 PLG COG6 CD79B MKKS ECE1 INAVA PRDM16 SAR1B IVNS1ABP DYNC2H1 IL23R COX2 SPINK1 APC TEK SMO USP27X SPINK5 RTEL1 CYBA MYH11 GPC3 SMAD4 KIFBP EPHX1 TGFBR2 RERE IL10RB FLNA PLA2G2A TCF4 MAD2L2 SKI TMEM237 SNAI2 PIK3CA ABCB11 CDCA7 SLC46A1 TEK RTTN FOXF1 CHST14 SDHC SLC5A1 TLR4 NCF1 RSPH3 COX7B CYBC1 PMS2 GNAS SRCAP TMPRSS6 TET2 FGFR3 WAS SEC23B WRAP53 FAS PAX3 HPS1 ATP7A PTEN SH3KBP1 RFXAP CARMIL2 BCOR CCDC28B KRAS GTF2I TNFRSF1A STAT4 PTEN FBLN5 TERT RUNX1 FAT4 LRP2 RIPK1 TWNK EP300 SETD5 DNAAF4 CCR1 MINPP1 UBAC2 WNT4 ITGB2 EFL1 TMEM138 PHOX2B BMPR1A RBM8A FAS NLRC4 UPF3B SLC10A2 RAD51 ANTXR2 TGFB1 HCFC1 NPHP1 XRCC2 CBLIF RECQL4 GREB1L ERAP1 FARSB PACS1 TRNL1 RET ODAD1 CTC1 PEX5 SRC SDHB PHOX2B KEAP1 NME8 LETM1 STX1A FLCN ELANE STAT5B RFWD3 APC ND5 APC MBTPS2 CCDC39 CFTR B9D1 WHCR GPC4 DLG3 MLH1 RFXANK KLRC4 DICER1 EP300 PRKAR1A F13A1 MLXIPL PIGN STX3 IQSEC2 CTNNB1 RET AK2 CD55 HLA-DRB1 MVK DKC1 RPS29 ACTG2 LRBA GPR35 MYO5B BAZ1B MED12 RSPH4A CDKN1A CCDC65 KIFBP ARHGEF6 DHCR24 WASHC5 ERCC2 AKT1 KCNAB2 EDNRB ADAM17 HLA-B TRNL1 UBE3B
Protein Mutations 1
C10D

HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


HP:0002242: Abnormal intestine morphology
Genes 1004
KMT2D SH2B1 RPS7 UBR1 DNAAF1 MITF GTF2IRD1 CAVIN1 SLC9A7 CTRC FRMPD4 SPINK5 APC PGAP2 ARVCF FANCM RPS15A RELA EDN3 RSPH9 NOTCH2 FCN3 RREB1 NAA10 HPGD PMS1 NPHP3 TCF4 POLG SHPK RFX6 PRSS1 HLA-DPA1 PEX11B CFC1 DNAH11 GJB6 POLG STK11 CDC45 GPC1 BUB1B DMD CYP27A1 SNAI2 WAS TJP2 CFAP221 MTTP MCC GJB2 AP1S1 CEP290 TTC7A BRIP1 HSD3B7 SEC24C CDK8 DDX59 BMPR1A PIK3CA B3GALT6 TWNK COL3A1 SATB2 CYBA FANCG FOXF1 HLA-DPB1 WAC KIT CLCN4 ENPP1 AKT1 TNPO3 XRCC4 NIPBL SIN3A FLNB ITGA8 PTRH2 EFEMP2 MYCN IL10RA ECE1 SLC9A3 TRNW CTLA4 ADAMTS3 SOX10 PRKCD SUFU HLA-B COL5A1 CCR6 AHI1 BLM CFAP300 AKR1D1 ADA2 VPS51 COL5A1 PEX19 USB1 MUTYH FAH MSH2 F12 NEK1 LIG4 POLE DNMT3B RPL35 FANCL NDUFB11 CPLX1 FAS FAN1 RFX5 SEMA3D FTSJ1 MYRF PIK3CA ODAD4 CCDC40 SPINT2 SRP54 MSH2 TINF2 CAV1 SDHC MKS1 VANGL1 CFTR FOXE1 CCBE1 AGA KMT2A FANCF MMP21 GDNF ASCL1 GATA6 ND4 RPS19 FLI1 STAT1 MBTPS2 SALL4 BMPR1A L1CAM SOX10 LONP1 L1CAM BTK MSH6 NOTCH3 CXCR4 RSPH1 MEFV CCBE1 RET PALLD SMAD4 SMAD4 SKIV2L STAT1 ISL1 HMBS ALG3 SNAI2 TCOF1 FOXJ1 FANCI NRAS CREBBP PEX6 NOTCH2 CFAP298 SALL4 PORCN CEP57 FGFR1 RAD21 PIGV SMAD7 CLMP DOK7 FGF8 SBDS RET RERE FLNA TCTN3 PTPN22 DACT1 SLC6A8 TTC7A TRNS2 CDON EDNRB FGF20 C1R MMEL1 RASGRP1 FANCA DMP1 TTC12 RPS19 IL12A-AS1 KLLN PPP1R12A TYMP CDKN1B GAS1 TGFB1 CCN2 MAP3K7 HYLS1 NPM1 GAS2L2 CTLA4 IL12A CNKSR2 PTPRJ APC IRF5 SAR1B GDNF DSE USP9X DHODH RPGR NSUN2 JAK3 PDGFRA FERMT1 DNAJC21 MSH2 DNAL1 NCF4 MPI MYCN RHBDF2 DDX59 TGFB1 MKS1 EXOC6B RPS26 EWSR1 SLC39A4 FLNA SMO RNF43 MNX1 RPGRIP1L FBN2 ASCL1 APC SLC29A3 BAX ABCB1 PEX10 MSH3 JAK1 RET PGM3 DNAJB13 JMJD1C TP53 BUB1 PALB2 TRNK SDHC ZEB2 EDN3 TMEM237 TBX1 ZAP70 ATRX NCF4 COX4I2 ODAD2 PEX12 HCCS B2M ENG DNAI1 MCM6 MDM2 MADD CEP104 FANCC AXIN2 LIMK1 MED12 AMACR PIGL HMGA2 ZBTB24 PCSK1 APC NCF1 EP300 IL2RB NRTN CDKN2A SAA1 EP300 PMS1 RPS10 PLCG2 BRCA2 POLG TTC37 PIGO LTBP4 ACOX2 IGLL1 SLC6A19 ODAD3 PERCC1 SYP BRCA2 PTCH1 HNRNPK EDNRB IGHM PDGFRB FASLG SOX10 MUSK EPCAM APC TMEM216 CISD2 GDF2 BUB1B CYBB RAD54B MLH1 EDN3 SLC6A8 PLG AURKA GPIHBP1 FLCN TYMP COX3 CD3G COG8 PIGV USF3 ACVRL1 CYBB MTTP SERPING1 LPIN2 NTHL1 SETBP1 ITGA6 STRA6 FANCB STAT3 CPLANE1 GLI2 SLX4 DNMT3B RECQL4 SLC2A2 RPL31 MYO1H LEMD3 HMBS GABRD SEMA4A TRMT5 PALB2 ASXL1 NEK10 CCDC22 DMPK DCC RPL5 MKS1 RPS27 PTCH1 TFAP2A RPS24 RPL35A UFD1 ARL13B AHI1 UBE2T SRP54 MEFV RTEL1 DNAAF2 KDM3B SF3B4 ACTG2 EIF2AK3 ABCB4 ARL6 PEX12 BDNF AP1S1 MYOD1 HNRNPK PIGY SALL1 HELLS IDS ZEB2 PIGO POLE SMC1A EYA1 RNF43 PIBF1 SETD2 ERCC4 SIX3 OCRL DZIP1L NEUROG3 CENPF PAX3 PDGFRL SMC3 POU2AF1 ARPC1B GATA1 POLG RAPSN TSR2 HLA-DRB1 PHOX2B DLC1 CEP41 BMPR1A HDAC8 MLH3 CHD7 POLR1C EFL1 TERC BUB3 RAD51C RBM10 MASP2 TRIP13 CC2D2A BMPR1A FGFR2 AIRE PARN HSD3B7 RFWD3 DNAAF6 OPLAH SDHD WFS1 GDNF NHP2 NOD2 ERGIC1 COMT ZMYND10 BLNK PLA2G4A KRAS MSH6 EDNRB KAT6A ARX SDHB COL5A2 TP53 WT1 LIPA SDHC RPS6KA3 SMAD4 KDM6A SALL1 SERPING1 SEMA3C EDN3 TMEM67 PIGN MYLK DNAH1 POLD1 UBR1 NODAL ND6 PIEZO1 IRGM ALG13 LRRC56 COL1A1 DHCR7 AGTR2 MPI FREM1 ZNF711 F13B INSR BMPR1A LBR BBS1 SDHD ASXL1 ARID1B KIT FGFR1 ARL3 RET RRM2B SETD5 CDKN2A SHH JAK3 PIK3C2A CFTR AMACR GATA1 CTBP1 MYO5B CEP120 MCIDAS ARX PTEN MYC FGFR2 TP53 CTNNB1 BCOR RAD51C SUFU DLL1 RAB39B PEX13 B3GLCT TGFBR2 CLIP2 CYBC1 ELN RET ALDH18A1 GDNF HIRA GP1BB DRC1 TP53 DIS3L2 IRF5 ARMC9 MEN1 ZMPSTE24 COX1 CEP41 CSPP1 CCNQ PTF1A ELN MYD88 SPAG1 BUB1 PORCN PHOX2B PMS2 FOXP3 SOX10 RPL27 SEC23B POLG CBL POLA1 PKHD1 MITF AXIN2 EDN3 PPOX MIR17HG TCF3 GDI1 RPL11 GREM1 CHEK2 PTCHD1 STXBP2 CREBBP STK36 DOCK8 STK11 PEX2 TTC37 DACT1 SMAD4 EDNRB POLR1D TDGF1 KRAS GLA AP1B1 PHOX2B LRRC6 RPL15 INPP5E FANCD2 FAT4 MLH3 CHST14 CIITA KIT BACH2 DNAJC21 MUTYH PEX26 IL12RB1 CCNO IL21 HYDIN IL2RA KIT CTC1 TSPAN7 C12ORF65 BAAT PRTN3 KIT FRAS1 LIG4 MYCN TRNS1 TRNH AAGAB TTC7A INPP5E KATNIP SALL4 SI SKIV2L ZAP70 MNX1 ZNF81 BRCA1 RPS6KA3 SLC7A7 FGFRL1 RARB RMRP GATA6 ND1 ADAMTS3 LIPA PEX3 CASP10 PAK3 ZEB2 C4A RPL18 TRNQ KIAA0586 LBR SBDS DNAI2 LMOD1 CYP7B1 PDGFRA PEX1 CHRM3 NUP88 TRNE TLR2 SERPING1 TNFAIP3 ELN PTCH2 DNAH9 MSH2 ASXL1 DHCR7 F5 KITLG SDHB AMER1 NCF2 MKKS PIK3CA FOXP3 PKD1 CEP57 TNFSF15 AKT1 ZFPM2 APC SDHA TRNF WNT2B CEP120 XIAP MLH1 ODC1 PIGW ACSL4 ACTG2 FOXH1 KLHL7 MID2 LRRC8A RPL26 RMRP PTEN PTPN12 TBCE TCF4 MLH3 FBLN5 DISP1 TCTN2 MSH6 ACTA2 PEX14 GAS8 PEX16 DGAT1 NIPBL HABP2 RPS28 RAC2 SLCO2A1 SDHB C12ORF65 DNAAF3 CLMP LRP2 ZIC2 SRP54 PLVAP DYRK1A RPS20 RAD21 COL14A1 CDKN2C MED12 AXIN2 CCDC47 CPOX IL1RAPL1 RPS17 ITCH APC2 KIF7 ITGB4 ENG ZNF423 LCT SPIB TP63 NSD1 SPEF2 IL6 CREBBP TMEM237 HYOU1 TMEM231 TBX1 EPCAM JAK2 MECP2 ATP8B1 PGAP3 PRSS2 TBL2 IL10 MLH1 AKR1D1 ABL1 FANCE WIPF1 NCF2 GUCY2C MTOR RFC2 PSTPIP1 NPHP3 PNLIP NSD2 SALL4 CCDC103 OFD1 DNAAF5 GATA6 IL12A EDNRB LMNA EPCAM SOX10 EDN3 BRCA1 STAG2 EP300 SRCAP CDKN2B DCTN4 CLCA4 SIX1 FCGR2A MST1 TGIF1 DNAH5 MBTPS2 SEMA3E TCTN1 SRSF2 SLC18A3 ZNF41 ALG8 CD79A PIK3R1 HNRNPU NOP10 POLD1 CCND1 STEEP1 PLG COG6 CD79B MKKS ECE1 INAVA PRDM16 SAR1B IVNS1ABP DYNC2H1 IL23R COX2 SPINK1 APC TEK SMO USP27X SPINK5 RTEL1 CYBA MYH11 GPC3 SMAD4 KIFBP EPHX1 TGFBR2 RERE IL10RB FLNA PLA2G2A TCF4 MAD2L2 SKI TMEM237 SNAI2 PIK3CA ABCB11 CDCA7 SLC46A1 TEK RTTN FOXF1 CHST14 SDHC SLC5A1 TLR4 NCF1 RSPH3 COX7B CYBC1 PMS2 GNAS SRCAP TMPRSS6 TET2 FGFR3 WAS SEC23B WRAP53 FAS PAX3 HPS1 ATP7A PTEN SH3KBP1 RFXAP CARMIL2 BCOR CCDC28B KRAS GTF2I TNFRSF1A STAT4 PTEN FBLN5 TERT RUNX1 FAT4 LRP2 RIPK1 TWNK EP300 SETD5 DNAAF4 CCR1 MINPP1 UBAC2 WNT4 ITGB2 EFL1 TMEM138 PHOX2B BMPR1A RBM8A FAS NLRC4 UPF3B SLC10A2 RAD51 ANTXR2 TGFB1 HCFC1 NPHP1 XRCC2 CBLIF RECQL4 GREB1L ERAP1 FARSB PACS1 TRNL1 RET ODAD1 CTC1 PEX5 SRC SDHB PHOX2B KEAP1 NME8 LETM1 STX1A FLCN ELANE STAT5B RFWD3 APC ND5 APC MBTPS2 CCDC39 CFTR B9D1 WHCR GPC4 DLG3 MLH1 RFXANK KLRC4 DICER1 EP300 PRKAR1A F13A1 MLXIPL PIGN STX3 IQSEC2 CTNNB1 RET AK2 CD55 HLA-DRB1 MVK DKC1 RPS29 ACTG2 LRBA GPR35 MYO5B BAZ1B MED12 RSPH4A CDKN1A CCDC65 KIFBP ARHGEF6 DHCR24 WASHC5 ERCC2 AKT1 KCNAB2 EDNRB ADAM17 HLA-B TRNL1 UBE3B
Protein Mutations 1
C10D

Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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