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D016470: Bacteremia

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (6)


Name (Synonyms) Correlation
drug1558 Exebacase Wiki 0.82
drug859 CRI management Wiki 0.58
drug3155 Phage Therapy Wiki 0.58
Name (Synonyms) Correlation
drug864 CT-P59 Wiki 0.41
drug866 CT-Scan Wiki 0.41
drug3195 Placebo Wiki 0.05

Correlated MeSH Terms (7)


Name (Synonyms) Correlation
D004696 Endocarditis NIH 0.82
D011552 Pseudomonas Infections NIH 0.58
D014115 Toxemia NIH 0.22
Name (Synonyms) Correlation
D018805 Sepsis NIH 0.18
D007239 Infection NIH 0.05
D003141 Communicable Diseases NIH 0.04
D011014 Pneumonia NIH 0.03

Correlated HPO Terms (3)


Name (Synonyms) Correlation
HP:0100584 Endocarditis HPO 0.82
HP:0100806 Sepsis HPO 0.18
HP:0002090 Pneumonia HPO 0.03

Clinical Trials

Navigate: Correlations   HPO

There are 3 clinical trials


1 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Single Dose of Exebacase in Patients Receiving Standard-of-Care Antibiotics for the Treatment of Staphylococcus Aureus Bloodstream Infections (Bacteremia), Including Right-Sided Infective Endocarditis

The purpose of this superiority study is to evaluate the efficacy and safety of exebacase in addition to standard of care antibiotics (SoCA) compared with SoCA alone for the treatment of patients with Staphylococcus aureus (S. aureus) bloodstream infections (BSI), including right-sided infective endocarditis (IE). Patients will be randomized to receive a single intravenous dose of exebacase or placebo. Patients will receive SoCA selected by the investigators based on the protocol. Exebacase, a direct lytic agent, is an entirely new treatment modality against S. aureus. Exebacase is a recombinantly-produced, purified cell wall hydrolase enzyme that results in rapid bacteriolysis, potent biofilm eradication, synergy with antibiotics, low propensity for resistance, and the potential to suppress antibiotic resistance when used together with antibiotics. Exebacase represents a first-in-field, first-in-class treatment with the potential to improve clinical outcome when used in addition to SoCA to treat S. aureus BSI including IE.

NCT04160468
Conditions
  1. Staphylococcus Aureus Bacteremia
  2. Staphylococcus Aureus Endocarditis
Interventions
  1. Drug: Exebacase
  2. Drug: Placebo
MeSH:Bacteremia Endocarditis
HPO:Endocarditis

Primary Outcomes

Measure: Clinical responder rate at Day 14 in the methicillin-resistant Staphylococcus aureus (MRSA) population

Time: Day 14

Description: TEAEs will be summarized by treatment group.

Measure: Treatment-emergent adverse events (TEAEs) through Day 60

Time: Through Day 60

Secondary Outcomes

Measure: Clinical responder rate at Day 14 in all S. aureus patients

Time: Day 14

Measure: 30-day survival in the MRSA population

Time: Through Day 30

Measure: Clinical responder rate at Day 60 in the MRSA population

Time: Day 60

Measure: Clinical responder rate at Day 60 in all S. aureus patients

Time: Day 60

Measure: Clinical responder rate at Day 60 in right-sided IE patients (all S. aureus and MRSA populations)

Time: Day 60
2 Expanded Access Study of a Single Dose of Exebacase in Addition to Antistaphylococcal Antibiotics for the Treatment of Persistent Methicillin-Resistant Staphylococcus Aureus (MRSA) Bloodstream Infections (Including Right Sided Endocarditis) in Patients Who Are Hospitalized With Coronavirus Disease 2019 (COVID-19)

This is an open-label, expanded access study of exebacase used in addition to antistaphylococcal antibiotics in adult patients with persistent methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI), including right-sided endocarditis (R-IE), who are hospitalized with coronavirus disease 2019 (COVID-19). Patients with left-sided endocarditis (L-IE) are excluded. Patients will receive a single dose of exebacase. Patients will continue to receive antistaphylococcal antibiotics as prescribed by the treating physician. Exebacase Phase 3 study sites (Study CF-301-105) may participate in this Expanded Access study (Study CF-301-107). Exebacase, a direct lytic agent, is an entirely new treatment modality against S. aureus. Exebacase is a recombinantly-produced, purified cell wall hydrolase enzyme that results in rapid bacteriolysis, potent biofilm eradication, synergy with antibiotics, low propensity for resistance, and the potential to suppress antibiotic resistance when used together with antibiotics. Exebacase represents a first-in-field, first-in-class treatment with the potential to improve clinical outcome when used in addition to standard-of-care antibiotics to treat S. aureus BSI including IE.

NCT04597242
Conditions
  1. MRSA Bloodstream Infection
  2. MRSA Bacteremia
  3. MRSA Right-sided Endocarditis
  4. Covid19
Interventions
  1. Drug: Exebacase
MeSH:Infection Bacteremia Endocarditis
HPO:Endocarditis

3 Expanded Access Study of Phage Treatment in Covid-19 Patients on Anti-Microbials for Pneumonia or Bacteremia/Septicemia Due to A. Baumannii, P. Aeruginosa or S. Aureus

Bacteriophage treatment in Covid-19 patients being treated with Anti-Microbials for Pneumonia or Bacteremia/Septicemia.

NCT04636554
Conditions
  1. Covid19
  2. Bacteremia
  3. Septicemia
  4. Acinetobacter Baumannii Infection
  5. Pseudomonas Aeruginosa Infection
  6. Staph Aureus Infection
Interventions
  1. Other: Phage Therapy
MeSH:Infection Communicable Diseases Bacteremia Pseudomonas Infections Sepsis Toxemia Pneumonia
HPO:Pneumonia Sepsis


HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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Interventions

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MeSH

706 reports on MeSH terms

HPO

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