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Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug3655 | Repetitive Transcranial Magnetic Stimulation (rTMS) Wiki | 0.71 |
| drug2168 | Internet-Delivered Cognitive Behavior Therapy (iCBT) Wiki | 0.71 |
| drug2342 | Lifestyle change promotion program Wiki | 0.71 |
Navigate: Correlations HPO
There are 2 clinical trials
This is a prospective, two-arm randomized controlled trial. 100 patients diagnosed with resistant depression in psychiatric care clinic in Edmonton, Alberta, Canada will be randomized to one of two conditions: (1) enrolment in rTMS sessions alone (2) enrolment in the rTMS sessions plus iCBT. Patients in each group will complete evaluation measures (eg, recovery, general symptomatology and functional outcomes) at baseline, 1 month, 3 months and 6 months. The primary outcome measure would be changes to scores on the Hamilton Depression Rating Scale. Patient service utilization data and clinician-rated measures will also be used to gauge patient progress. Patient data will be analyzed with descriptive statistics, repeated measures and correlational analyses.
Description: The scale contains 17 variables. Some are defined in terms of a series of categories of increasing intensity, while others are defined by a number of equal-valued terms. The form on which ratings are recorded also includes: four :Diurnal variation, de- realization, paranoid symptoms, obsessional symptoms.score Range of its score is from 0-54. from 0-6 means no depression. 7-17: mild depression 18-24:moderate depression 24 and more: Severe depression
Measure: The Hamilton Depression Rating Scale. Time: 6 monthsDescription: To assess depression as a symptom variable. Total scores range from 0 to 27 and high score means the worse outcome .The total score is obtained by adding the scores for each of the nine symptom domains of the DSM-IV MDD criteria: depressed mood, loss of interest or pleasure, concentration/decision making, self-outlook, suicidal ideation, energy/fatiguability, sleep, weight/appetite change, and psychomotor changes.
Measure: Quick Inventory of Depressive Symptomatology Self Report-16. Time: 6 monthsDescription: To assess suicidal ideation as symptom variable. Suicidal Ideation Score: The maximum suicidal ideation category (1-5 on the C- SSRS) present at the assessment. Assign a score of 0 if no ideation is present.
Measure: Columbia Suicide Severity Rating Scale. Time: 6 monthsDescription: To assess mania as a symptom variable.There are four items that are graded on a 0 to 8 scale (irritability, speech, thought content, and disruptive/aggressive behavior), while the remaining seven items are graded on a 0 to 4 scale. These four items are given twice the weight of the others to compensate for poor cooperation from severely ill patients. There are well described anchor points for each grade of severity. The authors encourage the use of whole or half point ratings once experience with the scale is acquired. Typical YMRS baseline scores can vary a lot. They depend on the patients' clinical features such as mania (YMRS = 12), depression (YMRS = 3), or euthymia (YMRS = 2). Sometimes a clinical study entry requirement of YMRS > 20 generates a mean YMRS baseline of about 30. Strengths of the YMRS include its brevity, widely accepted use, and ease of administration. The usefulness of the scale is limited in populations with diagnoses other than mania.
Measure: Young Mania Rating Scale. Time: 6 monthsDescription: To assess side effects as a functional variable. A patient self-report used to quantify the overall side effect burden. Used in combination with the PRISE. Rated for the last 7 days. Each item uses a 7-point Likert-type scale rated from 0 (i.e. no side effects) to 6 (i.e. intolerable). 3 global ratings encompass all side effects to study treatment experienced over the past week. One item rates frequency, another rating the intensity of side effects encountered in the prior week that the participant believes were due to the antidepressant treatment, and the third asks participants to estimate the overall burden or degree of interference in day-to-day activities and functioning due to the side effects.
Measure: Frequency, Intensity, and Burden of Side Effects Ratings *Edited for rTMS Time: 6 monthsDescription: To assess side effects as a functional variable. A patient self-report used to qualify side effects by identifying and evaluating the tolerability of each symptoms. Used in combination with the FIBSER. Rated for the last 7 days. 7 item assessment of the side effects in the following symptom domains; Gastrointestinal, Heart, Skin, Nervous System, Eyes/Ears, Genital/Urinary, Sleep, Sexual Functioning, and Other. Each domain has multiple symptoms which can be endorsed. For each domain the patient rates whether or not the symptoms are tolerable or distressing.
Measure: Patient Rated Inventory of Side Effects. Time: 6 monthsDescription: To assess disability as a functional variable.The scoring has three steps: Step 1 - Summing of recoded item scores within each domain. Step 2 - Summing of all six domain scores. Step 3 - Converting the summary score into a metric ranging from 0 to 100 (where 0 = no disability; 100 = full disability).
Measure: World Health Organization Disability Assessment 2.0 Time: 6 monthsDescription: To assess the quality of life as a functional variable. Each of the five dimensions comprising the EQ-5D descriptive system is divided into five levels of perceived problems: LEVEL 1: indicating no problem LEVEL 2: indicating slight problems LEVEL 3: indicating moderate problems LEVEL 4: indicating severe problems LEVEL 5: indicating unable to/extreme problems A unique health state is defined by combining one level from each of the five dimensions.
Measure: (The EuroQol-5 Dimension Assessment). Time: 6 monthsDescription: To assess patient satisfaction with service as a service variable.Identify survey questions that receive low scores and prioritize improving those areas (i.e., connect them to investigators strategic goals or propose them as an area of focus for the Board). Benchmark results against: The previous survey results Investigators peers Industry standard Best practices "Bright spots" in primary care
Measure: Patient Satisfaction/ Community Service Experience Survey Time: 3 monthsThe main objective of the study will be to evaluate the effectiveness of an adjuvant lifestyle-based intervention for treatment-resistant patients with major depressive disorder. Patients will be allocated to one of these three groups: 1)Treatment prescribed by their mental health team plus written lifestyle change suggestions 2)Treatment prescribed by their mental health team plus written lifestyle change suggestions plus 8-week Mindfulness-based cognitive therapy (MBCT) program 3) Treatment prescribed by their mental health team plus written lifestyle change suggestions plus 8-week lifestyle change promotion program. We will collect patient data using the questionnaires administered at baseline, immediately after the intervention, and at six and 12-month follow-up. The primary outcome will be depression severity and secondary outcomes will include health-related quality of life.
Description: Beck Depression Inventory-II (BDI-II)
Measure: Depression severity Time: 12 monthDescription: Questionnaire (EQ-5D)
Measure: Health-related quality of life Time: 12 monthAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on December 13, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports