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D013118: Spinal Cord Diseases

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug1369 Doxycycline Wiki 0.45
drug973 Chloroquine Wiki 0.38
drug2230 Ivermectin Wiki 0.21

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D001855 Bone Marrow Diseases NIH 1.00

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0002143 Abnormality of the spinal cord HPO 1.00
HP:0005561 Abnormality of bone marrow cell morphology HPO 1.00

Clinical Trials

Navigate: Correlations   HPO

There is one clinical trial.


1 Study of Postural Stability in Subjects With Myelopathy Using a Portable Virtual Reality Balance Protocol

Veterans are at heightened risk of developing cervical spondylotic myelopathy (CSM) from rigors of military service. Balance and posturography are negatively affected in CSM, but require expensive equipment, and extensive training of personnel for data acquisition and interpretation. The Virtual Environment TBI Screen (VETS) is a simple and inexpensive construct that could be implemented as an aid in diagnosis and as an objective means to compare treatment modalities and track recovery. The goal for the SPiRE is to generate the critical data to support rigorous Merit studies of posturography for assessments of clinical course in the treatment and rehabilitation of CSM. The investigators' ultimate goal, if the SPiRE is successful, is to phase in objective posturography assessments as VA standard of care in CSM.

NCT03810781
Conditions
  1. Cervical Spondylotic Myelopathy
MeSH:Spinal Cord Diseases Bone Marrow Diseases
HPO:Abnormality of bone marrow cell morphology Abnormality of the spinal cord Myelopathy

Primary Outcomes

Description: The postural stability task involves six conditions during which veterans are instructed to look straight ahead and maintain an upright stance as stably as possible. Veterans are barefooted with feet comfortably placed ~25 cm apart. The six conditions are (1) Eyes Open (EO) Firm (2) Eyes Closed (EC) Firm, (3) Dynamic Scene (DYN) Firm, (4) EO Foam, (5) EC Foam, and (6) DYN Foam. Each condition is tested three times with the average center of pressure (COP) sway area used as a index of stability for that condition.

Measure: Virtual Environment TBI System (VETS) assessment of Static Posturography

Time: PreSurgery compared to otherwise healthy veterans

Description: It is expected that posturography, especially that from FOAM and EC conditions will be improved be surgical relief. This is a within comparison of veterans with CSM and receiving surgical relief through widening of the chord.

Measure: Change in Posturography

Time: Presurgery compared to 2 weeks, 6 weeks, and 6 months post-surgery. The Post-surgery endpoints are normally scheduled clinical follow ups.

Secondary Outcomes

Description: The Nurick scale is a 6-grade ordinal scale assessing gait impairment, with grades ranging from 0 (signs and symptoms of root involvement but no evidence of spinal cord disease) to 5 (chair bound or bedridden). The aggregate value of the Nurick scale will be related to posturography.

Measure: Nurick Scale

Time: PreSurgery compared to otherwise healthy veterans

Description: The NDI is a 10-item questionnaire addressing function activities (personal care, lifting, reading, work, driving, sleeping, and recreation), pain intensity, concentration, and headache. For each item, patients make their ratings on a 6-point Likert scale with values 0 = no disability and 5 = complete disability. Summed scores for each category are multiplied by 2 to give a total NDI score ranging from 0-100. NDI will be related to VETS posturography to determine the sensitivity of standing posture to degree of disability.

Measure: Neck Disability Index (NDI)

Time: PreSurgery compared to otherwise healthy veterans

Description: The SF-36v2 is a general health survey that includes mental and physical component scores to measure functional status and overall quality of life. The instrument includes 8 scales: physical functioning, role limitations physical pain, bodily pain, general health perceptions, vitality, social functioning, role limitations, emotional health, and mental health. The higher the score the more limitations. The total scale will be used to determine the sensitivity of VETS posturography to quality of life.

Measure: Short Form-36 version 2 (SF-36v2)

Time: PreSurgery compared to otherwise healthy veterans

Description: From the VETS, a ratio corresponding to the Rhomberg ratio of COP sway will be used to determine the degree static posture depends on visual input.

Measure: EC FIRM/EO FIRM ratio

Time: PreSurgery

Description: From the VETS, a ratio of COP sway will be used to determine the degree static posture is affected by reduced proprioception.

Measure: EO FOAM/EO FIRM

Time: PreSurgery compared to otherwise healthy veterans

Description: From the VETS, a ratio of COP sway will be used to determine the degree loss of visual information compounds reduced proprioception in static balance.

Measure: EC FOAM/EO FOAM ratio

Time: PreSurgery compared to otherwise healthy veterans

Description: From the VETS, a ratio of COP sway to determine the roll vection is induced by loss of proprioception.

Measure: DYN FOAM/DYN FIRM ratio

Time: PreSurgery compared to otherwise healthy veterans

Description: From the VETS, a ration of COP sway to determine the degree roll vection is induced.

Measure: DYN FIRM/ EO FIRM ratio

Time: PreSurgery compared to otherwise healthy veterans

HPO Nodes


HP:0002143: Abnormality of the spinal cord
Genes 351
PRKG1 SETD2 SMARCB1 NSUN2 MAT2A FIBP RIPPLY2 NOTCH2NLC ALDH18A1 DKK1 WASHC5 MTHFR RUNX2 LMNB1 RTL1 GTF2IRD1 FLVCR1 FA2H PRPS1 WNT7A TGFBR2 ARID2 HFE APC PHGDH ARID1B ELN PUF60 ARVCF MNX1 ZIC1 TRAF7 FANCM RORA NELFA RREB1 GJB2 DNA2 RAI1 LETM1 CTBP1 JMJD1C CREBBP FBN1 KDM1A ATXN3 MAFB CTNNB1 POLG PALB2 ACTB TBX1 IRF6 ACY1 SOX4 AKT1 FKTN ZIC1 NFIA MFN2 PSAT1 TBL2 TBX1 RAD51C RRM2B COL2A1 POMT2 SUFU ATXN2 FANCE B3GLCT NF2 GNPTAB CLIP2 CCNQ RFC2 ATXN3 RNASEH1 NSD2 NF1 KIF22 GJB1 FANCC BMS1 LIMK1 CCT5 KRIT1 HIRA GP1BB HMGA2 BRIP1 B3GALNT2 FRAS1 POLA1 CCM2 MORC2 DARS2 B3GALT6 EP300 SEC24C GCLC CCNQ ELN BRCA1 POMGNT1 EXT1 ARID1B TWNK ARSB MTHFR TBC1D24 PAX3 MTHFD1 CCND1 FANCG PORCN SOX11 MSX2 SLC25A19 PNPLA6 SMAD3 POLG BRCA2 COL2A1 PTCH1 IDS RAF1 FBLN1 SIN3A COLEC10 FXN SLC33A1 CEP290 SPG7 HAAO CREBBP ACTA2 BMPER PNPLA6 SMARCC2 SC5D PTPN11 MEOX1 SMAD3 ALDH18A1 IGF2 DDR2 MPO MFAP5 LOX NF1 GRIP1 TNFRSF11A FANCD2 CUL7 SNRPB TGFB2 NEPRO FLNA ACVRL1 TRIM36 RASA1 LIG4 PDCD10 MAD2L2 FANCL CPLX1 FBN1 LARGE1 RAB23 FANCB PIK3CA IKBKG ARID1A SMARCB1 DLL4 FRAS1 SLX4 APOE FOXF1 SMARCE1 VANGL1 FLNB MYH11 TBX6 SALL4 C11ORF95 LEMD3 FLI1 NAXE ATXN2 RTN2 SLC26A2 VANGL1 PUF60 SMAD4 ATXN3 FOXE1 MTR CCBE1 FGFRL1 COLEC11 NF2 FANCF GLI3 APP UFD1 MASP1 PAX3 FUZ SALL4 ABCA1 UBE2T GTF2I CHRNG FLI1 NRAS LMX1B DACT1 TDP1 TBXT SMAD3 RUNX2 CHN1 KANSL1 DLL3 TGFBR1 COL2A1 POMT1 COL2A1 GNAS SH2B1 TWNK AMER1 CSPP1 KCNH1 A2M MINPP1 ALX4 OFD1 FREM2 IDS RBM8A ITGB4 PRMT7 PLP1 CCND1 KCNQ1OT1 PTCH2 ERCC4 TGFB2 SMARCD1 INPP5E RAD51 PHEX SMARCA4 ATXN3 GDF3 MMACHC GMPPB BRAF CREBBP SC5D TMEM216 CYP7B1 HES7 KIAA0586 XRCC2 FANCI NSD2 DPF2 VHL RECQL4 FLNA AMER1 CREBBP MASP1 MAN2B1 MYH3 NOTCH2 ATXN1 MYLK KIF1B LYST GTF2E2 PORCN RELA LETM1 GDF6 TGFB3 BMP2 LOX COMP RFWD3 KANSL1 ZSWIM6 HBB WHCR TBX6 WNT7A FBN1 HES7 FOXC2 SETX GLRX5 DACT1 PLEC EXT2 EP300 GDF6 FANCB GLB1 MEG3 FKRP NF1 DNAJC3 MYH3 MAP3K7 FANCA NEK9 H19 DLK1 VANGL2 PTPN11 PHGDH RMRP ENG PLAU LZTR1 NOTCH3 BAZ1B CCL2 EXTL3 PRPS1 COMT NOS3 IDUA GCLC TNXB LFNG MTRR CCT5 TRPV4 MESP2 HABP2 GALNS ABCD1 NOTCH3 RMRP FOXE3 IDS
Protein Mutations 0
SNP 0

HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


HP:0002143: Abnormality of the spinal cord
Genes 351
PRKG1 SETD2 SMARCB1 NSUN2 MAT2A FIBP RIPPLY2 NOTCH2NLC ALDH18A1 DKK1 WASHC5 MTHFR RUNX2 LMNB1 RTL1 GTF2IRD1 FLVCR1 FA2H PRPS1 WNT7A TGFBR2 ARID2 HFE APC PHGDH ARID1B ELN PUF60 ARVCF MNX1 ZIC1 TRAF7 FANCM RORA NELFA RREB1 GJB2 DNA2 RAI1 LETM1 CTBP1 JMJD1C CREBBP FBN1 KDM1A ATXN3 MAFB CTNNB1 POLG PALB2 ACTB TBX1 IRF6 ACY1 SOX4 AKT1 FKTN ZIC1 NFIA MFN2 PSAT1 TBL2 TBX1 RAD51C RRM2B COL2A1 POMT2 SUFU ATXN2 FANCE B3GLCT NF2 GNPTAB CLIP2 CCNQ RFC2 ATXN3 RNASEH1 NSD2 NF1 KIF22 GJB1 FANCC BMS1 LIMK1 CCT5 KRIT1 HIRA GP1BB HMGA2 BRIP1 B3GALNT2 FRAS1 POLA1 CCM2 MORC2 DARS2 B3GALT6 EP300 SEC24C GCLC CCNQ ELN BRCA1 POMGNT1 EXT1 ARID1B TWNK ARSB MTHFR TBC1D24 PAX3 MTHFD1 CCND1 FANCG PORCN SOX11 MSX2 SLC25A19 PNPLA6 SMAD3 POLG BRCA2 COL2A1 PTCH1 IDS RAF1 FBLN1 SIN3A COLEC10 FXN SLC33A1 CEP290 SPG7 HAAO CREBBP ACTA2 BMPER PNPLA6 SMARCC2 SC5D PTPN11 MEOX1 SMAD3 ALDH18A1 IGF2 DDR2 MPO MFAP5 LOX NF1 GRIP1 TNFRSF11A FANCD2 CUL7 SNRPB TGFB2 NEPRO FLNA ACVRL1 TRIM36 RASA1 LIG4 PDCD10 MAD2L2 FANCL CPLX1 FBN1 LARGE1 RAB23 FANCB PIK3CA IKBKG ARID1A SMARCB1 DLL4 FRAS1 SLX4 APOE FOXF1 SMARCE1 VANGL1 FLNB MYH11 TBX6 SALL4 C11ORF95 LEMD3 FLI1 NAXE ATXN2 RTN2 SLC26A2 VANGL1 PUF60 SMAD4 ATXN3 FOXE1 MTR CCBE1 FGFRL1 COLEC11 NF2 FANCF GLI3 APP UFD1 MASP1 PAX3 FUZ SALL4 ABCA1 UBE2T GTF2I CHRNG FLI1 NRAS LMX1B DACT1 TDP1 TBXT SMAD3 RUNX2 CHN1 KANSL1 DLL3 TGFBR1 COL2A1 POMT1 COL2A1 GNAS SH2B1 TWNK AMER1 CSPP1 KCNH1 A2M MINPP1 ALX4 OFD1 FREM2 IDS RBM8A ITGB4 PRMT7 PLP1 CCND1 KCNQ1OT1 PTCH2 ERCC4 TGFB2 SMARCD1 INPP5E RAD51 PHEX SMARCA4 ATXN3 GDF3 MMACHC GMPPB BRAF CREBBP SC5D TMEM216 CYP7B1 HES7 KIAA0586 XRCC2 FANCI NSD2 DPF2 VHL RECQL4 FLNA AMER1 CREBBP MASP1 MAN2B1 MYH3 NOTCH2 ATXN1 MYLK KIF1B LYST GTF2E2 PORCN RELA LETM1 GDF6 TGFB3 BMP2 LOX COMP RFWD3 KANSL1 ZSWIM6 HBB WHCR TBX6 WNT7A FBN1 HES7 FOXC2 SETX GLRX5 DACT1 PLEC EXT2 EP300 GDF6 FANCB GLB1 MEG3 FKRP NF1 DNAJC3 MYH3 MAP3K7 FANCA NEK9 H19 DLK1 VANGL2 PTPN11 PHGDH RMRP ENG PLAU LZTR1 NOTCH3 BAZ1B CCL2 EXTL3 PRPS1 COMT NOS3 IDUA GCLC TNXB LFNG MTRR CCT5 TRPV4 MESP2 HABP2 GALNS ABCD1 NOTCH3 RMRP FOXE3 IDS
Protein Mutations 0
SNP 0

Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

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4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

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