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D020181: Sleep Apnea, Obstructive

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (13)


Name (Synonyms) Correlation
drug664 Blood sampling (venesection) Wiki 0.41
drug1086 Comparator full face mask 1 Wiki 0.41
drug4442 Toffee Full Face Mask Wiki 0.41
Name (Synonyms) Correlation
drug1087 Comparator full face mask 2 Wiki 0.41
drug3999 Sleep Education Wiki 0.41
drug4144 Standardised questionnaires Wiki 0.41
drug1088 Comparator full face mask 3 Wiki 0.41
drug740 CBT-OSA Wiki 0.41
drug666 Blood test for IgG antibodies against SARS-CoV-2 Wiki 0.41
drug1916 Home Sleep Apnea Testing or In-hospital Polysomnography Wiki 0.41
drug2319 Lemborexant 10 mg Wiki 0.29
drug665 Blood test Wiki 0.29
drug3195 Placebo Wiki 0.02

Correlated MeSH Terms (12)


Name (Synonyms) Correlation
D012891 Sleep Apnea, NIH 0.83
D001049 Apnea NIH 0.71
D008173 Lung Diseases, Obstructive NIH 0.10
Name (Synonyms) Correlation
D029424 Pulmonary Disease, Chronic Obstructive NIH 0.09
D009103 Multiple Sclerosis NIH 0.09
D012598 Scoliosi NIH 0.09
D012120 Respiration Disorders NIH 0.09
D008171 Lung Diseases, NIH 0.07
D040921 Stress Disorders, Traumatic NIH 0.07
D013313 Stress Disorders, Post-Traumatic NIH 0.07
D013577 Syndrome NIH 0.04
D011014 Pneumonia NIH 0.02

Correlated HPO Terms (7)


Name (Synonyms) Correlation
HP:0002870 Obstructive sleep apnea HPO 1.00
HP:0010535 Sleep apnea HPO 0.83
HP:0002104 Apnea HPO 0.71
Name (Synonyms) Correlation
HP:0006536 Pulmonary obstruction HPO 0.10
HP:0006510 Chronic pulmonary obstruction HPO 0.09
HP:0002088 Abnormal lung morphology HPO 0.07
HP:0002090 Pneumonia HPO 0.02

Clinical Trials

Navigate: Correlations   HPO

There are 6 clinical trials


1 Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD

Approximately 20 million Americans suffer from Obstructive Sleep Apnea (OSA) creating risks for major health problems, including dementia, heart attack, and stroke. Obesity, a growing problem for Americans and Veterans alike, is the greatest risk factor for the development of OSA. Male gender and smoking, other OSA risk factors, are common in Veterans. Given the high comorbidity of these risk factors in Veterans, OSA presents a significant health burden to Veterans. The investigators' prior work provides evidence that OSA occurs in up to 69% of Vietnam-era Veterans with PTSD. OSA is easily treated; however, 15-30% of OSA patients are non-compliant with continuous positive airway pressure (CPAP), the standard OSA treatment. The proposed research aims to facilitate adherence to CPAP treatment by testing a novel cognitive-behavioral therapy intervention in Veterans with PTSD. If successful, it may represent an approach that could be applied to the rehabilitation of other chronic conditions with similar barriers to care.

NCT02641496
Conditions
  1. Obstructive Sleep Apnea
  2. PTSD
  3. Posttraumatic Stress Disorder
Interventions
  1. Behavioral: CBT-OSA
  2. Behavioral: Sleep Education
MeSH:Sleep Apnea Syndromes Sleep Apnea, Obstructive Stress Disorders, Traumatic Stress Disorders, Post-Traumatic
HPO:Obstructive sleep apnea Sleep apnea

Primary Outcomes

Description: The CPAP machine will measure the number of hours that the CPAP mask is on the participant's face and in use.

Measure: Time in hours of "mask-on" CPAP usage per night

Time: 1 year

Secondary Outcomes

Description: Effect of CBT on Self-reported Everyday Activities, Mood and Quality of Life. The investigators hypothesize that after initiating CPAP treatment, Veterans in the CBT-OSA group will report more improvement in the ease of performing everyday activities compared to that reported by those in the Education group.

Measure: Functional Outcomes of Sleep Questionnaire (FOSQ)

Time: 1 year

Description: Effect of CBT on Cognitive Outcomes. The CBT-OSA group will have better cognitive outcomes than the Education group over time. The California Verbal Learning Test-II, Delayed Recall Score is the cognitive outcome measure.

Measure: California Verbal Learning Test, Second Edition (CVLT-II)

Time: 1 year

Description: Effect of CBT on PTSD. The CBT-OSA group will have fewer PTSD symptoms than the Education group over time. The PTSD Checklist for DSM-5 (PCL-5) will be the PTSD outcome measure.

Measure: PTSD Checklist for DSM-5 (PCL-5)

Time: 1 year
2 Impact of Obstructive Sleep Apnea on Covid-19 Outcomes (OSACOVID-19 Study): A Prospective Observational Cohort Study

Covid-19 infection is an on-going pandemic with worse diagnosis in adults with comorbid conditions such as hypertension and cardiopulmonary diseases. Obstructive sleep apnea (OSA) is common in those comorbidities and may contribute to worse prognosis for the Covid-19 cases.

NCT04363333
Conditions
  1. COVID
  2. Obstructive Sleep Apnea
  3. Pneumonia
Interventions
  1. Diagnostic Test: Home Sleep Apnea Testing or In-hospital Polysomnography
MeSH:Apnea Sleep Apnea Syndromes Pneumonia Sleep Apnea, Obstructive
HPO:Apnea Obstructive sleep apnea Pneumonia Sleep apnea

Primary Outcomes

Description: Defined as a decline of 2 categories from admission on a 7-category ordinal scale

Measure: The rate of clinical improvement

Time: 7 days

Description: Defined as a decline of 2 categories from admission on a 7-category ordinal scale

Measure: The rate of clinical improvement

Time: 14 days

Description: Defined as a decline of 2 categories from admission on a 7-category ordinal scale

Measure: The rate of clinical improvement

Time: 21 days

Description: Defined as a decline of 2 categories from admission on a 7-category ordinal scale

Measure: The rate of clinical improvement

Time: 28 days

Secondary Outcomes

Description: Time to hospital discharge, ICU discharge, weaning from intubation, weaning from supplemental oxygen, incident pneumonia, ARDS, in-hospital mortality

Measure: Clinical status - improvement

Time: 7, 14, 21, 28 days

Description: Defined as an increase in category on a 7-category ordinal scale from admission

Measure: Clinical status - worsening

Time: 7, 14, 21, 28 days

Other Outcomes

Description: Re-analysis of the correlation of obstructive sleep apnea (objectively verified) severity in terms of apnea-hypopnea index and oxygenation levels with the primary and secondary outcomes as described above (the rate of clinical improvement defined as a decline of 2 categories from admission on a 7-category ordinal scale; time to hospital discharge, ICU discharge, weaning from intubation, weaning from supplemental oxygen, incident pneumonia, ARDS, in-hospital mortality as well as with the lung function, CO-diffusion capacity, cardiac function, CT thorax pathologies, biomarkers (cytokines, polymorphisms) and IgG-antibodies after 4 months.

Measure: Long-term outcomes

Time: 4-6 months after the initial hospital admission
3 Evaluation of Physical Activity Level and Sleep Quality in Patients With Obstructive Sleep Apnea Syndrome During Covid-19 Pandemic

As long as the people stay at home because of the Covid 19 outbreak, the investigators assume that the sleep quality of OUAS patients, like everyone else, and the sleep quality of COVID-19 outbreak are reduced due to anxiety and anxiety in people. In addition, we assume that sleep quality and physical activity level are related to health literacy level and fear of movement (kinesiophobia). In this study; the investigators aimed to determine how patients are affected by this process by evaluating sleep quality, physical activity, fear of movement and health literacy in OSAS patients during our stay in the COVID-19 outbreak.

NCT04451993
Conditions
  1. Obstructive Sleep Apnea-hypopnea Syndrome
MeSH:Sleep Apnea Syndromes Sleep Apnea, Obstructive Syndrome
HPO:Obstructive sleep apnea Sleep apnea

Primary Outcomes

Description: International Physical Activity Questionnaire/ In activity-specific scoring, walking under the heading of the fields is calculated by the sum of the moderate intensity activity and intensive activity in itself. From these calculations, a score is obtained in MET-minutes. There are 3 categories of physical activity level classification. Physical activity levels are classified as physically inactive (inactive), low level of physical activity (minimally active) and sufficient level of physical activity (very active)

Measure: Physical Activity

Time: 1 day

Description: The Pittsburgh Sleep Quality Index

Measure: Sleep Quality

Time: 1 day

Secondary Outcomes

Description: In order to measure the general sleepiness of people during the day, it was evaluated with a standard questionnaire, which is defined as Epworth sleepiness scale (EUS) and consists of 8 questions. The answers for each question are scored between 0 and 3 and the total score is obtained. The score obtained above 10 in EUS has high sensitivity and specificity for daytime sleepiness.

Measure: Daytime Sleepiness

Time: 1 day

Description: Tampa Kinesiophobia Scale (TKS)The person gets a total score between 17-68. The high score on the scale indicates that kinesiophobia is also high

Measure: Fear of movement

Time: 1 day

Description: Translated into Turkish TURKEY health literacy SCALE-32 (Tsoy-32) will be used. It was used to evaluate the literacy rates of individuals over the age of 15. 0 indicates the lowest health literacy and 50 indicates the highest health literacy.

Measure: Health literacy

Time: 1 day

Other Outcomes

Description: In the human circadian rhythm, the Morning Morning-Evening Survey (SAA) form was used, which determined morning and evening types.

Measure: Circadian rhythm evaluation

Time: 1 day
4 Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

This study will evaluate the influence of sleep apnea on clinical and radiological features of MS. Sleep apnea is associated with hypoxemia during sleep, which we believe is detrimental to MS. We will examine clinical data (MRI, lab results, medical history, labs, and sleep studies) of Dr. Sloane's MS patients. This will allow us to study correlations between MRI, clinical data, lab studies and sleep studies. We are specifically interested in the type of sleep apnea associated with MS, and whether MRI or clinical metrics of MS severity correlate with presence or absence of sleep apnea.

NCT04603196
Conditions
  1. Multiple Sclerosis
  2. Obstructive Sleep Apnea
MeSH:Apnea Sleep Apnea Syndromes Sleep Apnea, Obstructive Multiple Sclerosis Sclerosis
HPO:Apnea Obstructive sleep apnea Sleep apnea

Primary Outcomes

Description: Home Sleep Study Data

Measure: Home Sleep Study Data

Time: 1 year

Secondary Outcomes

Description: sleep quality, quality of life, depression and anxiety scales

Measure: Questionnaire data

Time: 1 year
5 F&P Toffee Full Face Mask Clinical Trial, NZ, 2020

This will be a prospective, multi-arm, randomized, and non-blinded clinical trial designed to evaluate the performance, comfort, and usability of the Toffee full face mask amongst participants who have been prescribed PAP therapy by a physician. This clinical trial will take place across three investigation sites with a sample of 45 participants.

NCT04615832
Conditions
  1. Positive Airway Pressure Therapy
  2. Obstructive Sleep Apnea
Interventions
  1. Device: Comparator full face mask 1
  2. Device: Comparator full face mask 2
  3. Device: Comparator full face mask 3
  4. Device: Toffee Full Face Mask
MeSH:Sleep Apnea, Obstructive
HPO:Obstructive sleep apnea

Primary Outcomes

Description: To assess the comfort of the mask as experienced by the participant. Comfort will be measured on a 5 point likert type scale from Very Uncomfortable to Very Comfortable. Different aspects of the mask such as cushion comfort, headgear comfort and overall comfort will be assessed using the same scale. Questions will be asked on a questionnaire and further qualitative responses will be captured during an interview.

Measure: Comfort

Time: Assessed 2 weeks after mask fitting

Description: To assess the ease of use of the mask as experienced by the participant. Questions regarding the ease of assembly, disassembly and mask fitting will be asked using a 5 point likert type scale with responses ranging from Very Easy to Very Difficult. Questions will be asked via a questionnaire with additional qualitative responses captured during an interview.

Measure: Usability

Time: Assessed 2 weeks after mask fitting

Description: To assess the long term reliability and durability of the mask when used in a home. environment over an extended period of time. Open ended questions during a semi-structured interview will be asked to participants who will provide qualitative information on their experience using the mask with specific regard to broken or degraded parts and components.

Measure: Reliability and Durability

Time: Assessed 4 months after mask fitting
6 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, 2-Period, Crossover Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Subjects With Moderate to Severe Obstructive Sleep Apnea and Adult and Elderly Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease

The primary purpose of the study is to determine whether lemborexant increases the apnea hypopnea index (AHI) on Day 8 of treatment in adult and elderly participants (adults greater than or equal to [>=] 45 to less than [<] 65 years; elderly >=65 to 90 years) with moderate to severe obstructive sleep apnea (OSA) compared with placebo, and using pulse oximetry determine whether lemborexant decreases the peripheral oxygen saturation (SpO2) during total sleep time (TST) on Day 8 of treatment in adult and elderly participants (adults >=45 to <65 years; elderly >=65 to 90 years) with moderate to severe chronic obstructive pulmonary disease (COPD) compared with placebo.

NCT04647383
Conditions
  1. Sleep Apnea, Obstructive
  2. Pulmonary Disease, Chronic Obstructive
  3. Respiration Disorders
Interventions
  1. Drug: Placebo
  2. Drug: Lemborexant 10 mg
  3. Drug: Placebo
  4. Drug: Lemborexant 10 mg
MeSH:Lung Diseases Apnea Sleep Apnea Syndromes Lung Diseases, Obstructive Pulmonary Disease, Chronic Obstructive Sleep Apnea, Obstructive Respiration Disorders
HPO:Abnormal lung morphology Apnea Chronic pulmonary obstruction Obstructive sleep apnea Pulmonary obstruction Sleep apnea

Primary Outcomes

Description: AHI is defined as the average number of apneas and hypopneas per hour of sleep. AHI will be assessed using polysomnography (PSG). The International Classification of Sleep Disorders (ICSD) (American Academy of Sleep Medicine, 2014) defines the severity of OSA according to the AHI: an AHI >5 to <15 is classed as mild, AHI >=15 to <30 as moderate, and AHI >=30 as severe.

Measure: OSA Cohort: AHI on Day 8 of Treatment

Time: Day 8

Description: SpO2 is an estimate of the amount of oxygen in the blood. It is the percentage of hemoglobin containing oxygen compared to the total amount of hemoglobin in the blood (that is, oxygenated hemoglobin versus oxygenated and non-oxygenated hemoglobin). SpO2 is monitored by noninvasive method known as transmissive pulse oximetry. TST is defined as the total time asleep in minutes using PSG.

Measure: COPD Cohort: Mean SpO2 During TST on Day 8 of Treatment

Time: Day 8

Secondary Outcomes

Description: AHI is defined as the average number of apneas and hypopneas per hour of sleep. AHI will be assessed using PSG. The ICSD (American Academy of Sleep Medicine, 2014) defines the severity of OSA according to the AHI: an AHI >5 to <15 is classed as mild, AHI >=15 to <30 as moderate, and AHI >=30 as severe.

Measure: AHI on Day 1 and Day 8 of Treatment

Time: OSA Cohort: Day 1; COPD Cohort: Day 1 and Day 8

Description: SpO2 is an estimate of the amount of oxygen in the blood. It is the percentage of hemoglobin containing oxygen compared to the total amount of hemoglobin in the blood (that is, oxygenated hemoglobin versus oxygenated and non-oxygenated hemoglobin). SpO2 is monitored by noninvasive method known as transmissive pulse oximetry. TST is defined as the total time asleep in minutes using PSG.

Measure: Mean SpO2 During TST on Day 1 and Day 8 of Treatment

Time: OSA Cohort: Day 1 and Day 8; COPD Cohort: Day 1

Description: SpO2 is an estimate of the amount of oxygen in the blood. It is the percentage of hemoglobin containing oxygen compared to the total amount of hemoglobin in the blood (that is, oxygenated hemoglobin versus oxygenated and non-oxygenated hemoglobin). SpO2 is monitored by noninvasive method known as transmissive pulse oximetry. TST is defined as the total time asleep in minutes using PSG.

Measure: Percentage of TST During Which the SpO2 is <90 percent (%), <85% and <80% on Day 1 and Day 8 of Treatment

Time: Day 1 and Day 8

Description: ODI is defined as (oxygen desaturations >=3%*60)/TST (that is, the average number of oxygen desaturations >=3% per hour of sleep), as defined by the American Academy of Sleep Medicine. ODI will be assessed using PSG.

Measure: Mean Oxygen Desaturation Index (ODI) on Days 1 and 8 of Treatment

Time: Day 1 and Day 8

Description: Desaturation is defined as decrease in the mean SpO2 of >=3% (over the last 120 seconds) that lasts for at least 10 seconds. Desaturation will be assessed using PSG.

Measure: Absolute Number of Desaturations (>=3% Reduction From Baseline SpO2) on Days 1 and 8 of Treatment

Time: Day 1 and Day 8

HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

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