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D018746: Systemic Inflammatory Response Syndrome

Developed by Shray Alag, The Harker School
Sections: Correlations, Clinical Trials, and HPO

Correlations computed by analyzing all clinical trials.

Navigate: Clinical Trials and HPO


Correlated Drug Terms (14)


Name (Synonyms) Correlation
drug2000 Hydroxychloroquine/Azithromycine Wiki 0.50
drug136 ARCT-021 Dose Regimen 1 Wiki 0.50
drug132 ARCT-021 Dose 1 Wiki 0.50
Name (Synonyms) Correlation
drug1090 Complement dosage Wiki 0.50
drug3516 Quinquina-Stevia/Azythromycin Wiki 0.50
drug137 ARCT-021 Dose Regimen 2 Wiki 0.50
drug1219 Cytokines dosage Wiki 0.50
drug134 ARCT-021 Dose 3 Wiki 0.50
drug1070 Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT) Wiki 0.50
drug133 ARCT-021 Dose 2 Wiki 0.50
drug135 ARCT-021 Dose 4 Wiki 0.50
drug69 4Plants/Azythromycin Wiki 0.50
drug2466 MMR vaccine Wiki 0.50
drug3195 Placebo Wiki 0.02

Correlated MeSH Terms (9)


Name (Synonyms) Correlation
D009102 Multiple Organ Failure NIH 0.20
D014115 Toxemia NIH 0.19
D058186 Acute Kidney Injury NIH 0.19
Name (Synonyms) Correlation
D018805 Sepsis NIH 0.16
D016638 Critical Illness NIH 0.06
D013577 Syndrome NIH 0.04
D012127 Respiratory Distress Syndrome, Newborn NIH 0.04
D055371 Acute Lung Injury NIH 0.04
D012128 Respiratory Distress Syndrome, Adult NIH 0.04

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0001919 Acute kidney injury HPO 0.19
HP:0100806 Sepsis HPO 0.16

Clinical Trials

Navigate: Correlations   HPO

There are 4 clinical trials


1 Uppsala Intensive Care Study of Mechanisms for Organ Dysfunction in Covid-19

The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.

NCT04316884
Conditions
  1. COVID-19
  2. Organ Dysfunction Syndrome Sepsis
  3. Organ Dysfunction Syndrome, Multiple
  4. Septic Shock
  5. Acute Kidney Injury
  6. Acute Respiratory Distress Syndrome
MeSH:Respiratory Distress Syndrome, Newborn Respiratory Distress Syndrome, Adult Acute Lung Injury Acute Kidney Injury Syndrome Systemic Inflammatory Response Syndrome Multiple Organ Failure
HPO:Acute kidney injury

Primary Outcomes

Description: KDIGO AKI score

Measure: Acute Kidney Injury

Time: During Intensive Care, an estimated average of 10 days.

Secondary Outcomes

Description: Acute Respiratory Distress Syndrome yes/no

Measure: ARDS

Time: During intensive care, an estimated average of 10 days.

Description: Death within 30 days of ICU admission

Measure: 30 day mortality

Time: 30 days

Description: Death within 1 year of ICU admission

Measure: 1 year mortality

Time: 1 year

Description: Development of Chronic Kidney Disease

Measure: Chronic Kidney Disease

Time: 60 days and 1 year after ICU admission

Description: Sequential Organ Failure Score as a continuous variable

Measure: SOFA-score

Time: During Intensive Care, an estimated average of 10 days.
2 Evaluation of Interleukine 6 (and Other Cytokines and Inflammatory Markers) in SARS-Cov-2 Infected Patients With a Systemic Inflammatory Response Syndrome

In patients infected by the SARS-Cov-2 Coronavirus a severely progressive disease requiring hospitalization in intensive care seems related to deregulation of cytokines with very high levels of IL-6, IL-2, IL-7, IL-10 and TNF-α. In order to elucidate the mechanism of this hyper inflammatory syndrome we will measure a panel of pro and anti inflammatory cytokines, as well as known markers of macrophage activation syndrome. To determine the role of activation of the complement cascade the most important complement factors and their activation markers will be measured. The changes of those parameters will be monitored after administration of an anti-IL6R antibody therapy.

NCT04346017
Conditions
  1. COVID-19
Interventions
  1. Diagnostic Test: Cytokines dosage
  2. Diagnostic Test: Complement dosage
MeSH:Systemic Inflammatory Response Syndrome

Primary Outcomes

Description: Interleukine 6, soluble IL6-R, complex IL6-IL6R concentration

Measure: IL6 concentration

Time: Before anti-IL6R treatment (baseline)

Description: Interleukine 6 soluble IL6-R, complex IL6-IL6R variation compared to baseline value

Measure: IL6 concentration change from baseline value

Time: Twice a week from day 1 to day 14 post anti-IL6R administration

Description: CH50, C3, C4, C3d, C5a, SC5b-9, C4a, MASP-2

Measure: Complement parameters

Time: Before anti-IL6R treatment (baseline)

Description: CH50, C3, C4, C3d, C5a, SC5b-9, C4a, MASP-2 variation compared to baseline values

Measure: Complement parameters change from baseline values

Time: Twice a week from day 1 to day 14 post anti-IL6R administration

Description: Concentration of TNFa, IFNg, IL1, IL7, IL10, IL12, IL17, IL18

Measure: Inflammatory cytokines baseline concentrations

Time: Before anti-IL6R treatment (baseline)

Description: Concentration of TNFa, IFNg, IL1, IL7, IL10, IL12, IL17, IL18 variation compared to baseline values

Measure: Inflammatory cytokines change from baseline values

Time: Twice a week from day 1 to day 14 post anti-IL6R administration

Secondary Outcomes

Description: sCD25, sCD163, sCD14, glycosylated ferritin

Measure: Concentration of markers of macrophage activation

Time: Before anti-IL6R treatment (baseline)

Description: sCD25, sCD163, sCD14, glycosylated ferritin variation compared to baseline values

Measure: Markers of macrophage activation change from baseline values

Time: Twice a week from day 1 to day 14 post anti-IL6R administration
3 Use of a Live Attenuated Vaccine Repurposed as an Innate Immune-based Preventive Against COVID-19-associated Sepsis/Inflammation

The objective of this randomized clinical trial is to test whether administration of live attenuated MMR vaccine (measles mumps rubella; Merck) to eligible adults at highest risk for contracting COVID-19 (healthcare workers, first responders), can induce non-specific trained innate immune leukocytes that can prevent/dampen pathological inflammation and sepsis associated with COVID-19-infection, if exposed.

NCT04475081
Conditions
  1. Sepsis Syndrome
Interventions
  1. Biological: MMR vaccine
MeSH:Sepsis Toxemia Systemic Inflammatory Response Syndrome
HPO:Sepsis

Primary Outcomes

Description: peripheral blood monocytic MDSCs (M-MDSC) and/or granulocytic MDSCs (G-MDSC) determined by flow cytometry from whole blood samples as percentage/fold increase over baseline

Measure: Induction of myeloid-derived suppressor cells (MDSCs)

Time: 14 days post-vaccination

Description: peripheral blood monocytic MDSCs (M-MDSC) and/or granulocytic MDSCs (G-MDSC) determined by flow cytometry from whole blood samples as percentage/fold increase over baseline

Measure: Induction of MDSCs

Time: 30 days post vaccination

Description: peripheral blood monocytic MDSCs (M-MDSC) and/or granulocytic MDSCs (G-MDSC) determined by flow cytometry from whole blood samples as percentage/fold increase over baseline

Measure: Induction of MDSCs

Time: 60 days post vaccination

Description: peripheral blood monocytic MDSCs (M-MDSC) and/or granulocytic MDSCs (G-MDSC) determined by flow cytometry from whole blood samples as percentage/fold increase over baseline

Measure: Induction of MDSCs

Time: 12 months post vaccination

Secondary Outcomes

Description: COVID-19 antibodies (seropositive) or COVID-19 RNA+ as evidence of infection

Measure: COVID-19 infection positive

Time: 14 days post-vaccination

Description: COVID-19 antibodies (seropositive) or COVID-19 RNA+ as evidence of infection

Measure: COVID-19 infection positive

Time: 30 days post-vaccination

Description: COVID-19 antibodies (seropositive) or COVID-19 RNA+ as evidence of infection

Measure: COVID-19 infection positive

Time: 60 days post-vaccination

Description: COVID-19 antibodies (seropositive) or COVID-19 RNA+ as evidence of infection

Measure: COVID-19 infection positive

Time: 12 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 14 days post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 30 days post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 60 days post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 3 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 4 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 5 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 6 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 7 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 8 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 9 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 10 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 11 months post-vaccination

Description: Sepsis/lung inflammation, ICU/ventilator usage, in-patient health related co-morbidities and self-reporting mental status (such as general fatigue/stress level)

Measure: Health questionnaire

Time: 12 months post-vaccination
4 Extracorporeal Blood Purification Therapy in Critically Ill Patients: an Interactive,Web-based,Multicenter,Observational Prospective Registry

Worldwide, the use of Extracorporeal Blood Purification (EBP) in everyday clinical practice is becoming increasingly common, particularly in critical care settings. The efficacy of most of these treatments on removal of inflammatory mediators is the main rationale behind the use of EBP in critically ill patients with multiorgan dysfunction. Nonetheless, there are still some doubts as to the clinical efficacy of bacterial toxins and cytokines removal and many clinical trials aiming at exploring the effect of EBP on long-term outcomes of septic patients have failed to demonstrate consistent results regarding 28 day- or hospital-mortality rates. The primary aim of this observational prospective web-based registry is to define the possible clusters of critically ill patients - treated with extracorporeal blood purification therapies worldwide - who are homogeneous regarding both clinical and treatment characteristics and seem to benefit the most from EBP.

NCT04580680
Conditions
  1. Critical Illness
  2. Acute Kidney Injury
  3. Sepsis
  4. Systemic Inflammatory Response Syndrome
Interventions
  1. Device: Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT)
MeSH:Acute Kidney Injury Critical Illness Systemic Inflammatory Response Syndrome
HPO:Acute kidney injury

Primary Outcomes

Description: Define the possible clusters of critically ill patients - treated with extracorporeal blood purification therapies worldwide - that are homogeneous regarding both clinical and treatment characteristics thanks all the treatment and baseline clinical variables extracted from the patient Case Report Forms (CRFs).

Measure: Define the possible clusters of critically ill patients

Time: 10 days after Extracorporeal Blood Purification Therapy (EBPT) initiation

Secondary Outcomes

Description: Define as ≥ 20% decrease in Vasoactive-Inotropic Score (VIS) at 48 hours with respect to baseline to assess the correlation between cluster membership and positive short-term outcome (i.e. an improvement in hemodynamic stability and inflammatory status).

Measure: To assess the correlation between cluster membership and positive short-term outcome.

Time: 48 hours after EBPT initiation

Description: To assess the correlation between cluster membership and positive long-term outcome, defined as patient survival at ICU discharge.

Measure: To assess the correlation between cluster membership and positive long-term outcome.

Time: 10 days after EBPT initiation

Description: To assess the correlation between positive short-term outcome and changes from baseline in clinical parameters and all treatment at 12 and 24 hours (as from the patient CRFs).

Measure: To assess the correlation between positive short-term outcome and changes from baseline.

Time: 24 hours after EBPT initiation

Description: Timing of initiation of a specific Extracorporeal Blood Purification (EBT) treatment will be described.

Measure: To describe the clinical circumstances under which clinicians opt for specific techniques of extracorporeal blood purification therapy worldwide.

Time: 10 days after EBPT initiation

Description: Absolute and relative frequencies of those clinical variables relevant to the application of a specific EBP treatment will be described.

Measure: To describe the clinical circumstances under which clinicians opt for specific techniques of extracorporeal blood purification therapy worldwide in terms of absolute and relative frequencies of clinical variables.

Time: 10 days after EBPT initiation

Description: EBP utilization will be described in terms of cumulative incidence among all the enrolled patients from all participating centers

Measure: To describe EBP utilization rates in intensive care units worldwide.

Time: 10 days after EBPT initiation

Description: EBP utilization will be described in terms of of yearly absolute frequencies and cumulative incidence among all the enrolled patients from all participating centers.

Measure: To describe EBP utilization rates in intensive care units worldwide in terms of absolute frequency

Time: 10 days after EBPT initiation

Description: Utilization of Continuous Renal Replacement Therapy(CRRT), Intermittent Hemodialysis (IHD), and Hybrid Renal Replacement Therapies as well as of the different membranes will be described in terms of relative frequencies.

Measure: To describe EBP in terms of relative frequencies for treatment type in intensive care units worldwide.

Time: 10 days after EBPT initiation

Description: For each EBP treatment will be described absolute and relative frequency of chosen anticoagulation strategy

Measure: To describe EBP in terms of technical characteristics in intensive care units worldwide.

Time: 10 days after EBPT initiation

Description: For each EBP treatment will be described average flow rates (variables: blood flow rate, dialysate flow rate, replacement flow rate pre-filter, replacement flow rate post-filter, effluent flow rate, net ultrafiltration rate).

Measure: To describe EBP in terms of average flow rates in intensive care units worldwide.

Time: 10 days after EBPT initiation

HPO Nodes


HPO

Alphabetical listing of all HPO terms. Navigate: Correlations   Clinical Trials


HPO Nodes


Reports

Data processed on December 13, 2020.

An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.

Drug Reports   MeSH Reports   HPO Reports  

Interventions

4,818 reports on interventions/drugs

MeSH

706 reports on MeSH terms

HPO

306 reports on HPO terms

All Terms

Alphabetical index of all Terms

Google Colab

Python example via Google Colab Notebook