SNPMiner Trials by Shray Alag

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Report for SNP rs12143842

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials

1 Genetics of QT Response to Moxifloxacin

The purpose of this study is to assess the ability of common genetic variants in aggregate to predict drug-induced QT prolongation in healthy subjects using moxifloxacin.

NCT01936480 Cardiac Arrhythmias Drug: Moxifloxacin 400mg once time Drug: Placebo
MeSH:Arrhythmias, Cardiac
HPO:Arrhythmia

For example, SNP rs12143842 is a C/T SNP; for each copy of the T allele the QT interval is 3.50 msec higher such that individuals with the TT genotype have a QT interval 7 msec higher than those with CC genotype and individuals with the CT genotype have a QT interval 3.5 msec higher.

Primary Outcomes

Description: We will measure the QT interval on ECG up to 6 hours after administration of moxifloxacin or placebo

Measure: QT interval duration

Time: 6 Hours

HPO Nodes

HP:0011675: Arrhythmia
Genes 591
MEFV PEX5 LMNA GATA6 TPM1 ABCA12 GABRA3 TET2 CYTB PCCB XK COX3 KYNU ND5 SCNN1A CPT2 NAA10 TRNS2 TAZ PHOX2B TWNK RRM2B KCNH2 AKAP9 TRPM4 BRAF KCNE5 TSR2 PRKAG2 BSCL2 SOX10 MYH7 ABCC8 VPS33A LIPT1 ERCC6 TRNL1 ND4 PKP2 COX3 GYG1 SGO1 CALM1 TRNS1 UCP2 MFAP5 TNNI3K JUP DAXX KCNJ2 PEX10 TRNL1 PSMB8 SLC2A10 LMNA ALG10B RAF1 TMEM43 RYR2 TOP3A SCN1B CDH23 MYH7 PPA2 GPC4 PEX19 ND4L NDUFB11 MYLK2 KCNQ1 CACNA2D1 ATP6 TMEM70 RPL15 KCNJ2 ND1 DES SCN5A PIK3CA CYTB ELP1 RYR1 LMNA AKT1 MEN1 CAV3 CLCNKB RPS10 COX2 DNMT3A KCNQ1 LZTR1 SOS1 EFEMP2 ND2 PAX8 AKAP10 RIT1 ACADM FHL1 HCN4 KCNH2 FBP1 ABCC9 FOS CLCF1 KCNQ1 SCN5A FGFR3 HCN4 LMNA ND1 TRNQ CASQ2 VHL EMD CACNA1S CASQ2 NDUFB11 KCNE1 KCNH2 GNAI2 RAF1 RPL35 IFNG KCNK3 KCNE1 COX7B GPD1L TGFB3 ND6 DSP KCNJ18 ATP6 SDHD ND5 HADHA HLA-DRB1 FBLN5 TRNS1 RPL26 PTEN SLC25A20 PTPN11 CALM1 SCN1B RAF1 LRP6 COX2 POLG2 COQ4 SYNE1 CACNA1D TGFBR2 MYL3 BVES FBP1 COX7B LDLRAP1 SYNE2 SCN5A SCN3B SLC25A4 ELN CAV3 GLA KCNE2 ABCG8 SYNE2 BMP2 SLC25A11 KCNE2 RPS19 RPL35A HLA-DPA1 GLA KCNH2 CALM2 TRDN NRAS BMP2 TRNL1 NPPA GPX4 MYH7 CALM2 NAA10 ATP6 GJA1 TSPYL1 CSRP3 LAMA2 WIPI2 AKAP9 GYG1 WAS SDHD GLUL GBA PTPN11 RPS24 HMGCL GNB5 MYH6 ND2 CALM2 TRDN PRKAG2 COX1 DTNA DMD LMNA CIZ1 HMBS CSF2RB ND5 SDHD SCN2B CAV3 PEX14 COQ9 ACADVL EMD ND4 SDHD KCNJ5 GPC3 CNBP PKP2 SALL4 TRNQ FMO3 RPS27 HMBS CAV1 CSF2RA RPS26 PTPN22 HADHB FHL1 ELN GPX4 PEX26 KIF1B KCNQ1 SDHB COX1 SLMAP SRY RPS28 RYR1 SCN5A FLNC GJA5 CACNB2 NEXN GPD1L HJV VHL SCN9A ND5 RPS7 KCNE3 PLN PCCA HNF1A SCN5A KCNA5 DST GDAP1 TLL1 RFC2 GTPBP3 HNF4A SLC19A2 TAB2 WIPF1 DSC2 LAMP2 ND6 KRAS USP18 MAX SCNN1B CACNA1S ND6 CTLA4 PRTN3 SCNN1G TANGO2 RPL27 RET EP300 CPT1A NKX2-5 ABCC9 PEX3 DSG2 TRNC CRELD1 GNA11 TRNF JUP SCN5A KCNQ1 EPAS1 SPECC1L CACNA1C DNAJC19 PHYH APOB LMNA RPL11 MYL4 PEX6 FOXC2 SDHC MYBPC3 CYTB NR2F2 TTN SCN5A ACADVL CPT2 AGPAT2 SLC12A3 ENPP1 HFE BRAT1 RPS29 LIMK1 GAA PRKAG2 TBL2 PEX2 CPOX GJA5 CALM3 DMD ACTN2 KIF1B ZMPSTE24 NDUFS2 TWNK TRNF NKX2-5 FLAD1 VHL SMAD3 MDH2 RPL18 MTO1 ISCU SCN3B TRDN COX3 FBXL4 CLIC2 LDB3 ABCC6 CLIC2 GATA5 KCNJ5 RASA2 ACAD9 TDP2 PEX1 TRNW SCN1B GSN SDHB SNTA1 TGFBR1 TECRL PPOX SLC40A1 FHL1 TP53 CASR PEX7 TTN BANF1 ACADL RRAS SDHC KCNE3 CLIP2 ERCC8 HTRA2 SLC19A2 SCN10A TNNT2 CACNA1S JUP RPL5 TNNI3 CAVIN1 COL4A1 KYNU EYA4 TMEM127 CACNA1S HLA-DPB1 SCN1B ACTC1 TPM2 ND1 DLST DSP NDUFB11 HSPG2 POLG2 RPS17 TRPM4 TMEM127 MYOZ2 TSPYL1 PTPN22 GATA4 TRNK SNTA1 MECP2 CACNB2 RPL31 TTR CPT2 SLC25A20 ND6 MTFMT KCND3 FOXC2 HLA-B TAB2 CALM2 TRNK CRLF1 TRPM4 ATRX TMEM43 SOS2 LDLR RRAS2 KCNE1 KCNJ11 SLC12A3 POLG RET VHL GNAQ SCN2B SDHB HCN4 ECE1 CYTB MYL2 KCNQ1 PEX6 RPS15A TRNV SCN4B RAF1 LMNA KCNJ18 KCNJ8 EFEMP2 SDHAF2 RANGRF PEX13 MGME1 TSC2 PEX11B TNXB ANK2 HBB TBX5 ADA2 NKX2-5 KCNE2 KCNQ1 TRPM4 TTPA PSMB8 CALM1 HLA-B MGME1 GJA1 CACNA2D1 GTF2I ND4L LARS2 TRNW PEX1 COX3 CACNA1C SCN4B MYPN LMNA BTNL2 TMEM70 TRNH SCN5A FH IKZF1 TECRL GATAD1 CPOX HFE TPM3 SCN5A CBL HCCS TNNC1 DMPK TRNS2 HRAS TAB2 TBX3 SMAD3 CTNNA3 SCN10A CASQ2 PGM1 ND4 RBM20 KCND3 SCN9A TANGO2 TSHR COX1 TBX3 MRPS14 CAVIN1 PLN SCN4A PPARG LMNA ELP1 ACTC1 BAZ1B DES MYH7 MAX LMNA TMEM43 SCN5A GNB5 RYR2 RET NPPA MYPN CACNA1C CPT1A ND1 DPP6 TRNE GTPBP3 RYR2 CAV3 SDHB HCCS TCAP KCNQ1 RET SDHA PEX16 ANK2 SDHD GATA1 DSP MRAS JPH2 PCSK9 KCNJ2 ABCC9 PEX5 KCNJ2 KCNE1 GDNF TNNI3 BMP2 PRDM16 CALM1 ABCG5 NOS1AP GTF2IRD1 PEX12 NUP155 CREBBP TSC1 TRDN A2ML1
Protein Mutations 0
SNP 1
rs12143842