SNPMiner Trials (Home Page)
Report for SNP rs13208321
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There is one clinical trial.
Clinical Trials
1 CGRP Induced Migraine Attacks in Patients With High and Low Genetic Load
The investigators hypothesized that migraine without patients with many genetic loci associated with migraine (high genetic load) would be more sensitive and get provoked more migraine attacks by calcitonin gene-related peptide (CGRP) compared to patients with few genetic loci associated with migraine (low genetic load).
NCT01924052 Migraine Without Aura Drug: CGRP MeSH:Migraine Disorders Migraine without Aura
HPO:Migraine Migraine without aura
One of the genetic loci (rs13208321) is located in a gene (FHL5) that is associated with the regulation of cAMP-responsive elements.
Primary Outcomes
Description: The difference in incidence of migraine-like attacks between patients with high genetic load and patients with low genetic load using verbal rating scale (VRS).
Measure: CGRP induced migraine attacks in patients with high and low genetic load Time: Change from baseline in headache intensity at 12 hours after the start of infusion of CGRPSecondary Outcomes
Description: The difference in area under the curve (AUC) for headache intensity scores (0-12 hours)
Measure: CGRP induced migraine attacks in patients with high and low genetic load Time: Change from baseline in headache intensity at 12 hours after the start of infusion of CGRP