SNPMiner Trials (Home Page)
Report for SNP rs6190
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There is one clinical trial.
Clinical Trials
1 Improving Learning and School Functioning in Latino Children With Cancer
This randomized clinical trial studies how well a high-intensity intervention parenting program works in improving learning and school functioning in Latino children with acute leukemia or lymphoblastic lymphoma. A high-intensity intervention program may help doctors to see whether training parents or caregivers in specific parenting skills and "pro-learning" behaviors will result in better learning and school outcomes for Latino children with acute leukemia or lymphoblastic lymphoma. It is not yet known if a high-intensity intervention program is more beneficial than a standard of care lower intensity parenting intervention.
NCT03178617 Acute Lymphoblastic Leukemia Acute Myeloid Leukemia Lymphoblastic Lymphoma Acute Leukemia Other: Educational Intervention Other: Educational Intervention Other: Quality-of-Life Assessment Other: Questionnaire Administration MeSH:Lymphoma Leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma Lymphoma, Non-Hodgkin
HPO:Leukemia Lymphoma Non-Hodgkin lymphoma
EXPLORATORY OBJECTIVES: I. Explore the associations between neurocognitive performance and polymorphisms in candidate genes previously reported to explain cognitive variability in childhood cancer survivors (e.g., the catechol-O-methyltransferase Val158Met polymorphism and the nitric oxide synthase [NOS3] 894T allele) or involved in the stress response (e.g., the Serotonin transporter rs25531 and the Glucocorticoid receptor rs6190).
Primary Outcomes
Description: Measured by the parent-reported Pediatric Quality of Life Inventory school domain.
Measure: Change in child's health-related quality of life school functioning Time: Baseline up to 12 monthsDescription: Measured by the Efficacy scale from the Parent Knowledge, Beliefs and Behaviors Questionnaire-3rd Revision (PBQ-R3).
Measure: Change in parental efficacy Time: Baseline up to 12 monthsSecondary Outcomes
Description: Measured by WIAT: reading and math scores and classroom grades from school report cards.
Measure: Objective academic performance (Child) Time: Up to 12 monthsDescription: Measured by the Conners Parent Report Attention subscale.
Measure: Attention performance (Child) Time: Up to 12 monthsDescription: Measured by PBQ-R3 Behaviors Scale.
Measure: Frequency of pro-learning behaviors (Parent) Time: Up to 12 monthsDescription: Measured by the Parents' weekly time spent with child in pro-learning behaviors and activities.
Measure: Frequency of pro-learning behaviors (Parent) Time: Up to 12 monthsDescription: Measured by PBQ-R3 Knowledge scale.
Measure: Knowledge of pro-learning parenting (Parent) Time: Up to 12 monthsMeasure: Children's scores on other neurocognitive tests as assessed by learning, memory, and processing speed Time: Up to 12 months
Measure: Parental reports of their children's HRQOL as measured by the PedsQL parent proxy questionnaire Time: Up to 12 months