SNPMiner Trials (Home Page)
Report for SNP rs3813929
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There are 2 clinical trials
Clinical Trials
1 Prospective Pharmacogenetic Testing and Clinical Outcomes in Patients With Early-Phase Psychosis
This study evaluates whether prospective pharmacogenetic testing is cost-effective in affecting clinical treatment outcomes in patients with early-phase psychosis.
NCT02566057 Schizophrenia Schizoaffective Disorder Schizophreniform Disorder Psychotic Disorders Bipolar Disorder Biological: PGx testing guided treatment (PGT) MeSH:Disease Schizophrenia Bipolar Disorder Psychotic Disorders Mental Disorders
HPO:Bipolar affective disorder Mania Psychosis Schizophrenia
For example, the serotonin 2C receptor gene (HTR2C) has variants that protect patients from antipsychotic drug induced weight gain (-759C/T, rs3813929); a deletion variant of the dopamine D2 receptor gene (DRD2) suggests poor efficacy with antipsychotic drug treatment (-141C Ins/Del, rs1799732); the short allele of the serotonin transporter gene (SLC6A4) is associated with antidepressant side effects.
Primary Outcomes
Description: Due to lack of efficacy or intolerability
Measure: Time to Discontinuation of First Medication Time: 12 monthsSecondary Outcomes
Description: The clinician is asked to fill out a questionnaire elaborating the medication decision-making process for each patient, including whether or not acting on the genetic information provided clinically relevant information.
Measure: Prescribing Behavior Change Based on the Results of the Pharmacogenetic Testing Time: 12 monthsOther Outcomes
Description: Assessed by Brief Psychiatric Rating Scale (BPRS)
Measure: Treatment Efficacy Time: 12 monthsDescription: Assessed by measures including Hillside Adverse Events Rating Scale (HAERS), Simpson-Angus Rating Scale for Extrapyramidal Symptoms (SARSES), Barnes Rating Scale for Drug-Induced Akathisia (BRSDIA), Abnormal Involuntary Movement Scale (AIMS)
Measure: Adverse Drug Response Time: 12 monthsDescription: Examine overall medical costs (including outpatient visits, procedures, hospitalizations, other professional charges, laboratory charges, and medication costs), as well as costs specifically associated with treatment of psychiatric symptoms based upon ICD9 code (for procedures and visits) and medication category. This information will be provided by insurance company for patients with ValueOptions insurance coverage.
Measure: Treatment Services Utilized Time: 12 months2 Clozapine Induced Weight Gain: A Pharmacogenetic Study
Clozapine is prescribed to patients with psychosis in whom other treatments have not worked. Research has shown, however, that clozapine may be associated with weight gain and abnormal blood sugar levels in some patients. There is strong evidence to suggest that genetic variation between individuals plays an important role in the development of these side effects in response to the medication. Our research aims to evaluate the effects of two genes and the blood level of clozapine on side-effects such as weight changes and blood sugar levels in patients receiving clozapine treatment. From out-patient clinics in Cwm Taf UHB, the investigators aim to recruit 160 patients who are taking clozapine; collect information/ measurements from recruits relating to size/ weight/ BMI, risk of diabetes and blood samples to measure markers of blood sugar, fat/lipids, clozapine and its breakdown products, blood cells and variants of two specific genes. From this information the investigators will be particularly interested to understand if there is any association between the variation in these two genes with weight gain or changes in blood sugar, in patients taking clozapine.
NCT03996356 Weight Gain Antipsychotic Agents Pharmacogenetics Other: No study intervention - observational study MeSH:Body Weight Weight Gain
HPO:Increased body weight
SNPs will be determined by polymerase chain reaction followed by restriction fragment length polymorphism analysis to determine (c.-2548G or c.-2548A) .. Serotonin 5-HT 2C receptor gene single nucleotide polymorphisms (SNPs) (rs3813929).
Primary Outcomes
Description: BMI will be calculated by weight (kg)/ height^2 (m^2).
Measure: Body-mass index (BMI) Time: 12 monthsDescription: SNPs will be determined by polymerase chain reaction followed by restriction fragment length polymorphism analysis to determine (c.-2548G or c.-2548A) .
Measure: Leptin gene promoter region single nucleotide polymorphisms (SNPs) (rs7799039) Time: 12 monthsDescription: SNPs will be determined by polymerase chain reaction followed by restriction fragment length polymorphism analysis to determine (c.-759C or c.-759T) .
Measure: Serotonin 5-HT 2C receptor gene single nucleotide polymorphisms (SNPs) (rs3813929) Time: 12 monthsSecondary Outcomes
Description: Haemoglobin A1c concentrations will be determined by ion-exchange HPLC (G8, Tosoh, Amsterdam, Netherlands)
Measure: Blood haemoglobin A1c concentration Time: 6 monthsDescription: Waist:hip ratio will be calculated by waist circumference (cm)/hips circumference (cm)
Measure: Waist:hip ratio Time: 12 monthsDescription: Serum lipid profiles will include total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride. These will be measured by enzymatic colorimetric methods on cobas-Roche analysers (Roche, Burges Hill, UK) except LDL cholesterol, which will be calculated using the Friedewald equation ([LDL cholesterol] = [Total cholesterol] - ([Triglyceride] / 2.2) - [HDL cholesterol]
Measure: Lipid profile Time: 12 monthsDescription: Clinical Global Impression (CGI) scale is a validated tool to assess clozapine side effects (Ref: Guy W, editor. ECDEU Assessment Manual for Psychopharmacology. 1976. Rockville,MD, U.S. Department of Health, Education, and Welfare)
Measure: Clozapine side effects assessment by Clinical Global Impression (CGI) scale Time: 12 monthsDescription: Clozapine:nor clozapine ratio is calculated by clozapine (ug/L)/ nor clozapine (ug/L) both measured by high-performance liquid chromatography with diode-array detection.
Measure: Clozapine:nor clozapine ratio Time: 12 months