SNPMiner Trials by Shray Alag

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Report for SNP rs2043211

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials

1 Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Subgingival Plaque and Blood Samples of Generalized Chronic Periodontitis Subjects With and Without Coronary Heart Disease

Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) will be analysed in the subgingival plaque and blood samples of generalized chronic periodontitis with and without coronary heart disease. The demographic and the periodontal parameters were assessed and correlated with the quantification of NLRP3 (rs4612666) and CARD8 (rs2043211) was analysed with RT-PCR

NCT04127487 Peri Periodontal Diseases Coronary Artery Disease
MeSH:Periodontitis Chronic Periodontitis Periodontal Diseases Coronary Artery Disease
HPO:Coronary artery atherosclerosis Periodontitis

Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Subgingival Plaque and Blood Samples of Generalized Chronic Periodontitis Subjects With and Without Coronary Heart Disease.

Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Generalized Chronic Periodontitis Subjects Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) will be analysed in the subgingival plaque and blood samples of generalized chronic periodontitis with and without coronary heart disease.

The demographic and the periodontal parameters were assessed and correlated with the quantification of NLRP3 (rs4612666) and CARD8 (rs2043211) was analysed with RT-PCR Expression of NLRP3 (rs4612666) and CARD8 (rs20432111) gene.

To determine the expression of NLRP3 (rs4612666) and CARD8 gene (rs2043211) polymorphisms in subgingival tissue samples of generalised chronic gingivitis periodontitis subjects with and without coronary artery disease.

To correlate the demographic variables and periodontal parameters and the expression of NLRP3 (rs4612666) and CARD8 (rs2043211) gene polymorphisms in generalised chronic periodontitis patients with coronary artery disease and compare them with systemically healthy chronic periodontitis patients

Primary Outcomes

Description: Expression of NLRP3 (rs4612666) and CARD8 (rs20432111) gene using RT-PCR

Measure: Expression of NLRP3 (rs4612666) and CARD8 (rs20432111) gene

Time: 12 months

Secondary Outcomes

Description: Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) gene using RT-PCR

Measure: Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) gene

Time: 12 months

HPO Nodes

HP:0000704: Periodontitis
Genes 42
PLG CTC1 WRAP53 PLG CXCR4 C1S NOP10 PARN ELANE C1R RTEL1 COL3A1 COL3A1 LYST FERMT1 NHP2 SLC35C1 C1S GORAB TERC ITGB2 TCIRG1 USB1 SRP54 AEBP1 FGF3 ELANE C1R CAT NPM1 CTSC CTSC FERMT1 CTSC NOTCH2 DKC1 GFI1 CTSC AP3B1 OCRL TINF2 TERT
Protein Mutations 2
C282Y C31G
SNP 8
rs11083519 rs2043211 rs20432111 rs30461 rs4612666 rs679620 rs8099917 rs8105790
HP:0001677: Coronary artery atherosclerosis
Genes 48
MAT2A MYH11 CEP19 LDLR ACTA2 ABCG8 ZMPSTE24 ACTA2 SMAD3 APOB TGFB2 ZNF687 ABCA1 SMPD1 LMNA LOX PRKG1 FOXE3 LMNA LIPC LMNA PCSK9 TGFBR1 APOB CYP7A1 LMNA MYH11 TGFB3 MYLK SERPIND1 ABCA1 MYH11 ELN LMNA ABCG8 ESR1 LMNA FBN1 APOE MFAP5 LMNA ABCG5 SMAD4 PPARG KCNJ5 LOX TGFBR2 LDLRAP1
Protein Mutations 1
C825T
SNP 19
rs10153820 rs1143623 rs1143633 rs1143634 rs12041331 rs16944 rs16969968 rs17561 rs1761667 rs2043211 rs20432111 rs2305619 rs4612666 rs4848306 rs6434222 rs7586970 rs7903146 rs8069645 rs8176528