SNPMiner Trials (Home Page)
Report for SNP rs7221412
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There is one clinical trial.
Clinical Trials
1 Clock Genes in Patients With Refractory Septic Shock (SeptiClock) - Pilot Study
Despite large efforts trying to improve diagnostic and therapy of sepsis have been made over the last decade (e.g. initiation of the Surviving Sepsis Campaign, defining evidence based sepsis therapy bundles) the mortality of septic shock remains high and causes high socioeconomical burden of disease. The purpose of this pilot study is to evaluate the design and conduct of a projected full scale clinical trial.
NCT02044575 Septic Shock MeSH:Shock, Septic Shock
Furthermore, polymorphisms such as rs7221412, a common polymorphism near period homolog 1 (PER1), was associated with the timing of activity rhythms and also showed a suggestive time-dependent relationship with both cerebral cortex and monocytes PER1 expression and an association with time of death (Lim ASP et al., 2012).
Primary Outcomes
Description: Circadian regulation by expression of clock genes
Measure: Assessment of circadian regulation Time: These parameters are measured during intensive care unit stay, for a maximum of 3 daysSecondary Outcomes
Measure: Time on mechanical ventilation Time: They are followed up until the end of intensive care unit stay - or, for a maximum of 28 daysMeasure: Intensive care unit length of stay Time: Participants will be followed for the duration of intensive care stay, an expected average of 4 weeks
Measure: Hospital length of stay Time: Participants will be followed for the duration of intensive care stay, an expected average of 5 weeks
Measure: Simplified Acute Physiology Score (SOFA II) Time: They are measured until the end of intensive care unit stay - or, for a maximum of 28 days.
Measure: Sequential Organ Failure Assessment (SOFA) Time: They are measured until the end of intensive care unit stay - or, for a maximum of 28 days.
Measure: Therapeutic Intervention Scoring System (TISS-28) Time: They are measured until the end of intensive care unit stay - or, for a maximum of 28 days.
Measure: Mortality Time: 6 months after intensive care unit discharge
Measure: Light frequencies Time: Light frequencies are measured until the end of intensive care unit stay - or, for a maximum of 28 days
Measure: Light levels (lux) Time: Light levels are measured until the end of intensive care unit stay - or, for a maximum of 28 days
Measure: Cortisol Time: This parameter is measured in ng/ml during intensive care unit stay, for a maximum of 3 days
Measure: Melatonin Time: This parameter is measured in pg/ml during intensive care unit stay, for a maximum of 3 days
Description: Quality of life is measured by SF-36 questionnaire
Measure: Quality of life Time: Up to 3 and 6 monthsDescription: Cognitive function is measured by Repeatable Battery for the Assessment of Neuropsychological Status
Measure: Cognitive function Time: Up to 3 and 6 monthsDescription: Ncounter neuroinflammation and micro rna panel are analysed
Measure: Multiplex-Genexpression analysis Time: These parameters are measured during intensive care unit stay, for a maximum of 3 daysOther Outcomes
Description: Nagalase Enzyme activity is expressed in nmol/min per Milliliter. Analysis is evaluated with the perioperative Nagalase results of 10 patients in the clinical trial Phydelio (EudraCT-No 2008-007237-47).
Measure: Nagalase enzyme activity Time: This parameter is measured at the beginning of the investigationDescription: Venous return will be assessed after ICU admission by venous return pressure gradient (dVR)
Measure: Venous return Time: This parameter is measured at the beginning of the investigation