SNPMiner Trials by Shray Alag

SNPMiner SNPMiner Trials (Home Page)

Report for SNP rs708272

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials

1 Influence of TaqIB (rs708272) Polymorphism in Cholesteryl Ester Transfer Protein (CETP) Gene on Functionality of HDL Particles, in the Pathway of Reverse Transport of Fasting and Post-prandial Cholesterol.

Reverse cholesterol transport (RCT) pathway explains the anti-atherosclerosis role of HDL. Post prandial hypertriglyceridemia is highly predictive of atherosclerosis. TaqIB polymorphism in CETP gene plays a role on HDL particles, and might give a link between TaqIB polymorphism and the cardioprotective efficiency of HDL particles. Our main objective was to compare post-prandial HDL particles between patients having B2 allele carriers (genotype AA) to B1 allele carriers (genotype GG), and their ability to mediate cellular cholesterol efflux, via SR-BI Scavenger Receptor class B type I (SR-BI) , ABCG1 and ABCA1 pathways.

NCT03109067 Healthy Volunteers Other: Standardized meal

Influence of TaqIB (rs708272) Polymorphism in Cholesteryl Ester Transfer Protein (CETP) Gene on Functionality of HDL Particles, in the Pathway of Reverse Transport of Fasting and Post-prandial Cholesterol.. Genetic and Metabolism of Post-prandial HDL Particles Reverse cholesterol transport (RCT) pathway explains the anti-atherosclerosis role of HDL.

Primary Outcomes

Description: Compare post-prandial HDL particles area under curve (AUC) between patients having B2 allele carriers (genotype AA) to B1 allele carriers (genotype GG)

Measure: Comparison of post-prandial HDL particles

Time: before the meal (time = 0 hour) vs 2 hours after

Secondary Outcomes

Description: Compare post-prandial HDL particles area under curve (AUC) between patients having B2 allele carriers (genotype AA) to B1 allele carriers (genotype GG), and their ability to mediate cellular cholesterol efflux, via SR-BI, ABCG1 and ABCA1 pathways.

Measure: Comparison of post-prandial HDL particles

Time: before the meal (time = 0 hour), 2 hours, 4 hours, 6 hours and 8 hours after the meal

Description: - Compare the increase of efflux capacity of postprandial HDL particles between individuals harboring a B2 allele compared to those harboring a B1 allele.

Measure: Efflux capacity of postprandial HDL particles

Time: before the meal (time = 0 hour), 2 hours, 4 hours, 6 hours and 8 hours after the meal

Description: Compare area under curves of triglyceridemia of apoB100 and apoB48 between individuals harboring a B2 allele (genotype AA) in the TaqIB polymorphism of the CETP gene.

Measure: Area under curves of triglyceridemia of apoB100 and apoB48

Time: before the meal (time = 0 hour), 2 hours, 4 hours, 6 hours and 8 hours after the meal

Description: Compare plasmatic concentrations of apoB100 between individuals harboring a B2 allele (genotype AA) in the TaqIB polymorphism of the CETP gene.

Measure: Plasmatic concentrations of apoB100

Time: before the meal (time = 0 hour), 2 hours, 4 hours, 6 hours and 8 hours after the meal

Description: Investigate the correlation between the area under curve of triglyceridemia and the efflux capacity of HDL particles.

Measure: Correlation between the area under curve of triglyceridemia and the efflux capacity of HDL particles.

Time: before the meal (time = 0 hour), 2 hours, 4 hours, 6 hours and 8 hours after the meal

HPO Nodes