SNPMiner Trials (Home Page)
Report for SNP rs174547
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There are 2 clinical trials
Clinical Trials
1 Gene - Diet Interactions in Fatty Acid Desaturase 1 Gene (FADSDIET)
Interactions between genes and environment, are likely to be crucial in the development of the common diseases such as type 2 diabetes. It was recently shown that FADS1 and FADS 2 genotypes are the strongest genes in a genome-wide analysis regulating serum fatty acid profile.The aim of this study is to test if subjects with the CC and TT genotypes of the FADS1 gene (rs174547) respond differentially to a diet supplemented with linoleic acid (substrate for FADS). We hypothesize that subjects with the TT genotype with more active desaturases will be more sensitive to dietary modification leading to more robust differences in serum FA profile, tissue inflammation and serum lipids.
NCT02543216 Fatty Acid Dietary Supplement: Sunflower oil
It was recently shown that FADS1 and FADS 2 genotypes are the strongest genes in a genome-wide analysis regulating serum fatty acid profile.The aim of this study is to test if subjects with the CC and TT genotypes of the FADS1 gene (rs174547) respond differentially to a diet supplemented with linoleic acid (substrate for FADS).
Inclusion Criteria: Participant of Metabolic syndrome in men (METSIM) cohort BMI 20-30 kg/m2 Healthy CC/TT genotype (rs 174547) Exclusion Criteria: Type 2 diabetes Other chronic disease Inclusion Criteria: Participant of Metabolic syndrome in men (METSIM) cohort BMI 20-30 kg/m2 Healthy CC/TT genotype (rs 174547) Exclusion Criteria: Type 2 diabetes Other chronic disease Fatty Acid Lean and overweight subjects (BMI >20kg/m2 <29kg/m2 ) with CC and TT genotypes of FADS1 polymorphism (rs174547) were recruited from the METSIM study (METabolic Syndrome in Men, currently >10000 men included from the population living in Kuopio).
Primary Outcomes
Measure: Fatty acid profile of serum lipid fractions Time: 4 weeksSecondary Outcomes
Measure: Serum lipids an lipoproteins Time: 4 weeksMeasure: Adipose tissue biopsies Time: 4 weeks
Measure: white blood cell samples Time: 4 weeks
2 Fatty Acid Desaturase Gene Locus Interactions With Diet (FADSDIET2)
Interactions between genes and environment, are likely to be crucial in the development of the common diseases such as type 2 diabetes. Recently, the investigators have obtained data that genotypes of genes encoding for fatty acid desaturases 1 and 2 (FADS1 and FADS2) are the strongest genes in a genome-wide analysis regulating serum fatty acid profile.The aim of this study is to test if subjects with different genotypes of the FADS2 gene respond differently to a diet supplemented with linoleic acid or alpha-linolenic acid (substrates for FADS2). The study hypothesizes that subjects will be more sensitive to the dietary modifications according to their genotype leading to more robust differences in serum FA profile, tissue inflammation and serum lipids.
NCT03572205 Fatty Acids Genetics Dietary Supplement: LA Dietary Supplement: ALA
Subcutaneous adipose tissue taken by open biopsy to collect 1-5 g of adipose tissue.. Inclusion Criteria: - Participants of METSIM study cohort with CC/TT FADS1 rs174547 SNP genotype.
Inclusion Criteria: - Participants of METSIM study cohort with CC/TT FADS1 rs174547 SNP genotype.
Primary Outcomes
Description: Fatty acid composition of serum lipid fractions
Measure: Change in fatty acid composition of serum lipid fractions Time: 8 weeksSecondary Outcomes
Description: Oral glucose tolerance test (OGTT) variables: fasting, 30 min and 120 min glucose and insulin measurements
Measure: Glucose and insulin metabolism response Time: 8 weeksDescription: Serum circulating levels of high-sensitivity C-reactive protein
Measure: Inflammatory markers response Time: 8 weeksDescription: Subcutaneous adipose tissue taken by open biopsy to collect 1-5 g of adipose tissue.
Measure: Adipose tissue biopsies Time: 8 weeks