SNPMiner Trials by Shray Alag

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Report for SNP rs1885988

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials

1 Web-based Weight Loss Intervention

Excess weight is a major risk factor underlying leading causes of death globally, including cardiovascular disease, type 2 diabetes, and some cancers. Among participants assigned to the same lifestyle intervention arms in prior weight loss randomized controlled trials, large inter-individual differences in weight loss success have been observed, ranging from >50lbs of weight loss to >10lbs of weight gain. Both genetic and non-genetic factors underlying differential adherence and weight loss success are poorly understood.

NCT03400696 Overweight and Obesity Behavioral: Lower carbohydrate diet Behavioral: Higher fiber diet Behavioral: Physical activity focused
MeSH:Overweight Weight Loss
HPO:Decreased body weight Weight loss

Primary aims include: a.) to confirm whether AG/GG individuals at MTIF3 rs1885988 lose more weight on lifestyle interventions; and b.) to test the performance of a randomized controlled trial vs. self-selection study design in terms of weight loss, drop-outs, and adherence.

Primary Outcomes

Measure: Change in weight from week 1 to week 12 of intervention

Time: 12 weeks

Secondary Outcomes

Measure: Change in waist circumference from week 1 to week 12 of intervention

Time: 12 weeks

Measure: Change in waist-to-hip ratio from week 1 to week 12 of intervention

Time: 12 weeks

HPO Nodes

HP:0001824: Weight loss
Genes 325
TRNF SCNN1B WT1 EPAS1 SCNN1A GABRA3 TRAIP COL1A1 PTEN MLX LIPA TCF4 STAT3 INSR LPIN2 HAVCR2 KLRC4 MC2R NPM1 JPH3 KIF1B H19 NOD2 PLAGL1 IL6 MECP2 IL12A WT1 TRNL1 POLG PRKAR1A BCL10 MRAP FOXP3 FIP1L1 KCNJ11 SDHD UBE2T INS CNTNAP1 KIF1B DAXX MST1 PML MALT1 VHL TBL1XR1 IL12A-AS1 TSHR PRNP CDH23 ERAP1 RPS20 MDH2 FLI1 BMPR1A CUL4B TP53 GJB3 FOXP1 TRIM28 B2M ND1 FANCL PDX1 SDHA ATP7B SCNN1G RHBDF2 RBBP8 MPL AKT1 NAB2 JAK2 ERCC5 WT1 COX2 EDN3 TP53 BCL2 JPH3 STAT6 TYMP EIF2AK3 KRAS PALB2 SNCA SEMA4A SDHC LRRK2 BRIP1 DCTN1 ACADM CACNA1S NBN FANCF IGH RET XRCC2 COL6A2 PRNP TSHR BRCA2 IGH HLA-B TRNQ NDP EDNRB UNC80 HLA-DPB1 DLST VPS35 PALB2 HSPG2 MLH1 TRIM37 TMEM127 STAR MEFV KCNJ18 FANCE C4A BMPR1A UBAC2 SDHD CALR PTPN22 KDSR POLG HLA-DRB1 KCNJ11 TRNS1 ERCC2 PTEN TRIP13 PLK4 TP53 RAD51 TTR EWSR1 IL23R PMS1 GIGYF2 F5 STAT3 ATR CHEK2 DNAJC13 BTK HYMAI FANCA MSH6 KRT1 POU6F2 HTT SLC9A6 PLA2G6 SUCLA2 FANCD2 TET2 SLC6A8 GJA1 ATRX PIK3CA PRNP KRT10 FANCM RET VHL CFTR SLC52A2 SDHAF1 SDHB SLC25A11 TLR4 BIRC3 ERCC4 SDHB GCK EPCAM IRF2BP2 LMNA KCNJ18 PIK3R1 HLA-DPA1 KRAS GDNF ACAT1 STAT4 SDHAF2 LRP12 SDHB DIS3L2 IL10 ATM COL5A2 IGH RB1 NNT NALCN PMS2 CYP24A1 BCOR SMAD4 ERCC3 BRCA2 ERCC4 TRIM28 PCNT SDHC BRCA2 RAD51C HLA-B JAK2 VPS13A SLC39A4 SDHD GBA SEMA3D AK2 TRNW COX3 RRM2B TGFBR2 HMGCL POLG UNC80 BRCA1 TYMP GATA4 COL5A1 RFWD3 SNCA BTNL2 SLX4 TRNH COX1 FH IKZF1 NOD2 GATA2 JAK2 REST ZBTB16 ABCC8 NUMA1 GPR35 TXNRD2 ND5 MAFB ND4 SLC11A1 BCL6 CENPJ TRNS2 COL12A1 HMBS PTPN22 FANCG STAT5B FANCI TP53 TGFB1 CENPE SEMA3C CEP152 AVP ABCC8 MPL RRM2B FAN1 FANCC CDC73 IL12B MAX ERCC4 FAS HLA-DRB1 CCR1 MAD2L2 FANCB TRPV4 GJB4 PALLD HLA-DRB1 HLA-DQB1 SLC52A3 EIF4G1 ATRIP PTEN CCND1 HLA-DRB1 RNF168 GPC3 NABP1 SDHB MSH2 ECE1 COL6A1 IFNGR1 JAK2 COL6A3 RET SDHA NRTN PANK2 CDKN2A GALT CACNA1S MLH3 ND6 CTLA4 PRTN3 RARA HLCS CCND1 TET2 ZFP57 HLA-B BRCA1 MPL THPO GNPTAB DCTN1 SDHD
Protein Mutations 2
I148M P12A
SNP 3
rs1885988 rs738409 rs9939609