SNPMiner Trials by Shray Alag

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Report for SNP rs12143842

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials

1 Genetics of QT Response to Moxifloxacin

The purpose of this study is to assess the ability of common genetic variants in aggregate to predict drug-induced QT prolongation in healthy subjects using moxifloxacin.

NCT01936480 Cardiac Arrhythmias Drug: Moxifloxacin 400mg once time Drug: Placebo
MeSH:Arrhythmias, Cardiac
HPO:Arrhythmia

For example, SNP rs12143842 is a C/T SNP; for each copy of the T allele the QT interval is 3.50 msec higher such that individuals with the TT genotype have a QT interval 7 msec higher than those with CC genotype and individuals with the CT genotype have a QT interval 3.5 msec higher.

Primary Outcomes

Description: We will measure the QT interval on ECG up to 6 hours after administration of moxifloxacin or placebo

Measure: QT interval duration

Time: 6 Hours

HPO Nodes

HP:0011675: Arrhythmia
Genes 611
SLMAP LIMK1 TTR ELP1 LMNA CPOX ND1 COX1 PTEN CSRP3 LMNA SCN5A SCN1B KCNK3 NF1 RRAS2 ELN CTLA4 KCNH2 RPL5 CACNB2 GATA6 KCNQ1 LMNA RRM2B ATP6 MRPS14 MFAP5 SYNE2 TRNC CLIC2 TSC1 CACNA1C BMP2 GNA11 BANF1 TRPM4 HCCS GLA TRNK TRNL1 ND4 TMEM43 GNB5 DMD POLG2 TNNT2 ERCC8 RAF1 TRDN KCNQ1 LMNA CALM1 FHL1 LRP6 TNNI3 GJA1 HLA-B TRNQ RUNX1 TRNK COX3 KCNQ1 NDUFS2 TTPA CACNA1C HRAS TNNT2 KCNE3 MYBPC3 SYNE1 CACNA1S BSCL2 SCN10A MRAS CALM3 ELN PIK3CA TAB2 SNTA1 ABCC9 CSF2RB TMEM70 COX3 ND4 ACADVL PAX8 SDHA DES TECRL SLC19A2 ABCG8 LMNA DAXX KCNE2 KCND3 PEX1 COQ4 AKAP9 RPS28 CYTB TRPM4 SLC25A20 PSMB8 TCAP FOXC2 DMD RET GLA LAMA2 RPL11 LAMP2 NKX2-5 SLC25A11 DST SCNN1A SCN5A KCNQ1 GALC SEMA3A LMNA FOS TRNQ GPD1L JPH2 RBM20 TSPYL1 HLA-DPB1 TP53 PRKAG2 AGPAT2 PKP2 PPA2 TNNI3 PLN COQ9 TRNS1 ND5 CACNA2D1 TPM1 GTF2IRD1 SDHC PEX16 PPARG SOS2 TRNH PEX11B MYOZ2 PCCB ALG10B EFEMP2 PEX5 MYH7 SDHD MYLK2 RET RFC2 KCNJ2 KCNJ5 LDLR ERCC6 WIPF1 DLST CASQ2 PCCA GJA1 CAV3 CPT1A PEX12 RAF1 GPC4 HNF1A TRNW EP300 GATAD1 SCN5A RYR2 TMEM43 BVES SDHB ND5 PTPN11 LMNA SCN5A ACTC1 CLIP2 PYGM SCNN1G GPX4 SCN4A EMD PEX5 XK CACNA1C WAS FLNC SCN5A ATP6 SCN5A GATA4 HCN4 TMEM70 RPS27 RPS7 CACNA1S ENPP1 TRNS2 MGME1 CAV3 GTPBP3 DMPK UCP2 TNNC1 KCNQ1 GNAI2 CACNA1S PEX19 AKT1 COX1 SRY KCNE1 MYPN MYL2 CREBBP DSC2 ND5 ACADM SDHB HBB SCN2B SOS1 MYH6 RYR1 LMNA PRTN3 SCN1B MYH7 MDH2 GSN CACNA1D ND6 ND6 DNMT3A PPOX GAA CYTB FBP1 SCN4B ELP1 BMP2 TAB2 ND4L TRNL1 HJV HMGCL KCNH2 KCNE1 RPS17 RET MEFV MYL4 LARS2 GPD1L RAF1 TANGO2 DPP6 BRAF CAV1 CPT2 TGFBR2 NR2F2 RYR2 NAA10 CPT1A RPL35A EFEMP2 ABCC6 COX2 RET KCND3 SCNN1A RPL31 RIT1 RPL15 ACTN2 KCNJ18 ACAD9 CPOX CAVIN1 GNAQ MGME1 ND2 MAX RAF1 ACTC1 HADHB SGO1 DSP RPL27 ND6 KIF1B SLC25A4 FLNC TGFB3 TNNI3 SMAD3 TRNL1 PRKAG2 MTO1 GPC3 ND6 KCNJ8 SCNN1B GNB5 ND1 CRELD1 KCNE2 KCNJ2 KCNE1 CBL PRDM16 GLUL RPS24 VHL PGM1 GATA1 GATA5 SDHB SDHAF2 VHL DTNA KCNQ1 CYTB GDAP1 A2ML1 SCN5A SALL4 FHL1 SCNN1A TRNF CACNB2 SCN10A ATRX TOP3A CPT2 HADHA COX7B WIPI2 CLCF1 CPT2 TMEM127 TDP2 CTNNA3 SDHD RPS26 GJA5 COX7B PHYH SCNN1B NKX2-5 CAV3 COX1 HSPG2 COX3 NPPA PEX26 HFE FBLN5 ND4 MYPN RPL26 RPS29 NPPA KCNA5 APOB SDHD SCN1B ND1 KCNH2 SDHD SLC25A20 KCNQ1 GDNF KCNJ18 TTN KCNE2 ECE1 KCNQ1 TRNE SDHC FH SYNE2 TSC2 BMP2 NOS1AP PEX6 TBX3 ABCC9 CALM1 COX3 PEX3 RPS10 TRDN EYA4 USP18 SCN3B HTRA2 CALM1 CIZ1 TBX5 JUP CALM2 RANGRF CASQ2 SCN5A CYTB PKP2 TRNV KCNJ11 TAZ TRDN TAB2 ACADL KCNJ2 TWNK ABCC8 IKZF1 PEX13 CALM3 KCNJ2 AKAP9 SCN9A NRAS MYH7 SNTA1 SCN9A NUP155 POLG EPAS1 SPECC1L SLC2A10 PTPN22 KCNE1 GTPBP3 DMPK NAA10 KYNU POLG2 MYL3 BAZ1B FLAD1 TRNS2 VHL PCSK9 ABCA12 CSF2RA CBL ISCU ASXL1 NDUFB11 PEX2 APRT TGFBR1 FBP1 HLA-DPA1 ANK2 SDHD DSG2 TLL1 CNBP TSHR SCN5A ND4L CAVIN1 SLC12A3 DSP FMO3 VPS33A LDB3 TANGO2 TTN CRLF1 TWNK RPS15A KCNE3 COX2 TRNF HFE GBA GTF2I IFNG EMD LIPT1 CACNA1S KCNJ5 TET2 SCN1B AKAP10 HCN4 MEN1 RASA2 SCN3B KCNE5 CLCNKB BRAT1 PEX6 ND1 ND2 RYR2 LDLRAP1 GJA5 MYH7 RPL18 UQCRFS1 KCNH2 TPM2 SOX10 DNMT3A COL4A1 TSR2 TSPYL1 HLA-B HNF4A LMNA TPM3 KRAS BTNL2 FOXC2 TECRL DNAJC19 TNNI3K PTPN22 SDHB JUP TRDN TRNW ABCG5 GYG1 TMEM127 LMNA CALM1 CASR CAV3 HCN4 ADA2 LZTR1 SRSF2 TRPM4 SLC12A3 PTPN11 ATP6 ND5 CACNA1C CACNA2D1 SMAD3 TMEM43 FBXL4 GPX4 PLN NKX2-5 SLC40A1 PEX10 TBL2 HMBS FHL1 HMBS PEX14 PRKAG2 RYR1 HCCS KYNU RPL35 DES ACADVL MAX SCN5A SCN4B MYPN PEX7 ABCC9 KIF1B MTFMT CALM2 GYG1 TRNS1 SCN2B KIF20A DSP HLA-DRB1 PSAP TNXB NDUFB11 CDH23 RPS19 RRAS JUP CASQ2 ANK2 PHOX2B NDUFB11 ZMPSTE24 CALM2 NEXN SLC19A2 SCNN1G VHL TBX3 CLIC2 TET2 PEX1 GABRA3
Protein Mutations 0
SNP 1
rs12143842