SNPMiner Trials (Home Page)
Report for SNP rs1790349
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There is one clinical trial.
Clinical Trials
1 Knowledge Innovation Project of CAS - Genetic and Nutritional Association Studies on Metabolism-related Diseases in Chinese Population -- Vitamin D Intervention Study
This is a double-blind, randomized, placebo-controlled trial. Based on inclusion and exclusion criteria, 400 eligible volunteers, who were 20-45 years, with 25-hydroxyvitamin D between 12.5-50 nmol/L and BMI between 18.5-28 kg/m2, were enrolled and randomly assigned to placebo or 2000 IU/d vitamin D3 arm, after taking placebo for one week. The study protocol was approved by the Ethics Committee of Huadong Hospital Affiliated to Fudan University, Shanghai and all participants provided written informed consents.In this 2-arm RCT we aimed to systematically investigate the effect of: 1. vitamin D3 supplement on serum 25(OH)D levels and the modifying factors; 2. genetic and non-genetic variants on vitamin D bioavailability; 3. vitamin D3 supplementation on metabolic profiles and circulating bone-turnover markers
NCT01998763 Vitamin D Deficiency Dietary Supplement: Placebo Dietary Supplement: Vitamin D3 MeSH:Vitamin D Deficiency
HPO:Low levels of vitamin D
In addition, we developed a genetic risk score (GRS) to evaluate the combined effect of three SNPs (rs4588, rs1790349 and rs2060793) from GC, NADSYN1/DHCR7 and CYP2R.
Primary Outcomes
Description: Serum 25(OH)D (D2+D3) concentration was measured by a liquid chromatography-mass spectrometry (LC-MS) method
Measure: 25-hydroxyvitamin D Time: 0,10,20 weekSecondary Outcomes
Description: Serum calcium was measured by an automatic biochemical analyzer
Measure: calcium Time: 0,10,20 weekDescription: Serum iPTH was measured by ADVIA Centaur XP Immunoassay System (Siemens, Germany)
Measure: parathyroid hormone Time: 0,10,20 weekDescription: Serum VDBP was measured by an ELISA kit
Measure: Vitamin D binding protein Time: 0,10,20 week