SNPMiner Trials by Shray Alag

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Report for SNP rs2043211

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials

1 Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Subgingival Plaque and Blood Samples of Generalized Chronic Periodontitis Subjects With and Without Coronary Heart Disease

Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) will be analysed in the subgingival plaque and blood samples of generalized chronic periodontitis with and without coronary heart disease. The demographic and the periodontal parameters were assessed and correlated with the quantification of NLRP3 (rs4612666) and CARD8 (rs2043211) was analysed with RT-PCR

NCT04127487 Periodontal Diseases Coronary Artery Disease
MeSH:Periodontitis Chronic Periodontitis Periodontal Diseases Coronary Artery Disease
HPO:Coronary artery atherosclerosis Periodontitis

Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Subgingival Plaque and Blood Samples of Generalized Chronic Periodontitis Subjects With and Without Coronary Heart Disease.

Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Generalized Chronic Periodontitis Subjects Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) will be analysed in the subgingival plaque and blood samples of generalized chronic periodontitis with and without coronary heart disease.

The demographic and the periodontal parameters were assessed and correlated with the quantification of NLRP3 (rs4612666) and CARD8 (rs2043211) was analysed with RT-PCR Expression of NLRP3 (rs4612666) and CARD8 (rs20432111) gene.

To determine the expression of NLRP3 (rs4612666) and CARD8 gene (rs2043211) polymorphisms in subgingival tissue samples of generalised chronic gingivitis periodontitis subjects with and without coronary artery disease.

To correlate the demographic variables and periodontal parameters and the expression of NLRP3 (rs4612666) and CARD8 (rs2043211) gene polymorphisms in generalised chronic periodontitis patients with coronary artery disease and compare them with systemically healthy chronic periodontitis patients

Primary Outcomes

Description: Expression of NLRP3 (rs4612666) and CARD8 (rs20432111) gene using RT-PCR

Measure: Expression of NLRP3 (rs4612666) and CARD8 (rs20432111) gene

Time: 12 months

Secondary Outcomes

Description: Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) gene using RT-PCR

Measure: Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) gene

Time: 12 months

HPO Nodes

HP:0000704: Periodontitis
Genes 42
TCIRG1 NOTCH2 TERT NHP2 RTEL1 CAT SLC35C1 ELANE C1S CTSC SRP54 CTSC NOP10 FGF3 PARN AEBP1 PLG COL3A1 OCRL USB1 CTSC TINF2 CTC1 CXCR4 PLG C1R FERMT1 DKC1 FERMT1 GORAB ITGB2 C1R NPM1 ELANE TERC AP3B1 GFI1 WRAP53 COL3A1 CTSC C1S LYST
Protein Mutations 2
C282Y C31G
SNP 8
rs11083519 rs2043211 rs20432111 rs30461 rs4612666 rs679620 rs8099917 rs8105790
HP:0001677: Coronary artery atherosclerosis
Genes 51
ZNF687 ACTA2 SERPIND1 LOX KCNJ5 LDLR SMAD4 ESR1 PRKG1 ABCA1 SMAD3 ABCC6 MFAP5 SMPD1 CYP7A1 ABCG8 LMNA ACTA2 CEP19 LMNA LOX TGFBR2 ELN APOE XYLT1 ABCA1 LDLRAP1 MYLK TGFB3 LMNA PCSK9 APOB APOB MAT2A FBN1 PPARG ZMPSTE24 LMNA LMNA LMNA TGFBR1 TGFB2 ABCG5 LMNA XYLT2 FOXE3 MYH11 MYH11 LIPC ABCG8 MYH11
Protein Mutations 1
C825T
SNP 19
rs10153820 rs1143623 rs1143633 rs1143634 rs12041331 rs16944 rs16969968 rs17561 rs1761667 rs2043211 rs20432111 rs2305619 rs4612666 rs4848306 rs6434222 rs7586970 rs7903146 rs8069645 rs8176528