SNPMiner Trials by Shray Alag

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Report for SNP rs11045585

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials

1 A Study of the Docetaxel Pharmacodynamics and Polymorphisms in ABCC2 and SLC01B3 in Caucasian and African-American Cancer Patients

This research trial studies deoxyribonucleic acid (DNA) in blood samples from Caucasian and African-American cancer patients who received docetaxel on clinical trial CLB-9871. Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about how docetaxel is used by the body.

NCT01015963 Bladder Cancer Breast Cancer Head and Neck Cancer Lung Cancer Unspecified Adult Solid Tumor, Protocol Specific Other: laboratory biomarker analysis
MeSH:Breast Neoplasms Lung Neoplasms Head and Neck Neoplasms Urinary Bladder Neoplasms
HPO:Bladder neoplasm Breast carcinoma Neoplasm of head and neck Neoplasm of the breast Neoplasm of the lung

Incidence of ABBC2 polymorphism (rs12762549) and a SLC01B3 polymorphism (rs11045585) with docetaxel exposure.

Incidence of SLC01B3 polymorphism (rs11045585).

Primary Outcomes

Measure: Incidence of ABBC2 polymorphism (rs12762549) and a SLC01B3 polymorphism (rs11045585) with docetaxel exposure

Time: Up to 2 years

Measure: Incidence of SLC01B3 polymorphism (rs11045585)

Time: Up to 2 years

Secondary Outcomes

Measure: Incidence of grade III/IV leukopenia/neutropenia (induced by docetaxel)

Time: Up to 2 years

HPO Nodes

HP:0003002: Breast carcinoma
Genes 97
CHEK2 MLH1 PIK3CA RAD54L CTNNB1 MLH1 KLLN RAD51 NQO2 APC RAD50 TP53 STK11 RAD51C PHB RAD51C PTEN BRCA1 KRAS CDH1 AKT1 NTHL1 IDH2 MRE11 TWIST1 TP53 XRCC3 BARD1 ATR CHEK2 CDH1 BRIP1 POLE AKT1 BRCA1 TP53 MSH2 CDKN2A BARD1 PALLD SEC23B CDKN2A SEC23B STK11 NBN RB1CC1 BRCA2 RAD51 BRCA2 AAGAB POLD1 AKT1 TP53 RNF43 NTHL1 IDH1 COL14A1 BRCA2 CHEK2 PALB2 TP53 RAD51D WRN KRAS BRIP1 PPM1D SDHB SLC6A17 HMMR SMAD4 MSH2 MSH6 PRKN AKT1 USF3 ESR1 BRCA2 PTEN SDHC PALB2 CHEK2 PIK3CA CASP8 PIK3CA PIK3CA ATM MDM2 FGFR2 APC OPCML BRCA1 BRCA1 SLC22A18 BRCA1 PTEN SDHD PALB2
Protein Mutations 73
A289T A864V C3435T D538G D769H D769N D769Y D988Y E380Q E542K E545K E709K E757A G309A G309E G598V G776C G776V H1047R I655V I767M L536H L536P L536Q L536R L755P L755S L786V L841V L858R L861Q L869R P125A P12A P13K P187S P535H P596L R108K R222C R572Y R678Q R831C R831H R849W R896C S310F S310Y S463P S653C S768I S8814A S9313A T47D T733I T790M T798I T798M T862I V244M V534E V600E V659E V697L V742I V769M V773M V774M V777L V842I Y537C Y537N Y537S
SNP 38
rs1011970 rs10407022 rs1045485 rs10941679 rs10995190 rs11045585 rs11133360 rs11249433 rs12762549 rs13281615 rs13387042 rs16942 rs1800566 rs2002555 rs2046210 rs2237060 rs2241193 rs2297480 rs236114 rs2380205 rs271924 rs2981582 rs3803662 rs3817198 rs4073 rs4646 rs4973768 rs614367 rs6504950 rs6971 rs704010 rs7333181 rs7349683 rs889312 rs909253 rs9344 rs9457827 rs999737
HP:0012288: Neoplasm of head and neck
Genes 25
FOXE1 RHBDF2 SDHB KIT HABP2 SDHA KIT MINPP1 FH CTHRC1 APC SDHC RHBDF2 RAD21 STK11 ASCC1 PDGFRA STAT1 RNF6 APC TGFBR2 WWOX MSR1 RSPRY1 DLEC1
Protein Mutations 2
E10A P13K
SNP 2
rs11045585 rs12762549
HP:0100526: Neoplasm of the lung
Genes 62
ERCC6 PRKN SFTPA2 IRF1 EGFR SLC22A18 FASLG TSC2 NAB2 KEAP1 DICER1 TSC1 REST TRPV3 CYP2A6 TSC1 TSC2 PTEN WRN STK11 C11ORF95 TSC1 MAP3K8 BAP1 ERBB2 POU6F2 MBTPS2 RELA PPP2R1B SLCO2A1 SFTPC TSC1 H19 TP53 DIS3L2 PERP CASP8 PDGFRB RB1 EWSR1 STAT6 KRAS MUC5B TRIM28 TERT NOTCH3 DICER1 GPC3 WT1 TRIP13 HPGD WT1 WT1 AKT1 PIK3CA TP53 TSC2 TRIM28 LMNA BRCA2 DICER1 BRAF
Protein Mutations 52
C1156Y C797S D594G F1174C F1174V G1202R G1269A G12C G12D G469A G719A G719C G719S G776C G776V I10A L1196M L1198F L523S L755S L833F L8585R L858R L859R L861G L861Q L861R N375S P13K P4503A R776G R831C S1400A S1400C S1400D S1400E S1400F S1400G S1400I S1400K S1800A S1900A S1900C S1900D S768I T790M T81C T890M V600E V769L V777L V843I
SNP 6
rs1047768 rs10937405 rs11045585 rs12762549 rs4488809 rs751402
HP:0009725: Bladder neoplasm
Genes 41
AXIN2 AAGAB DLC1 PLA2G2A RNF43 NTHL1 COL14A1 NRAS PTPRJ TP53 BUB1B TLR2 MLH3 PIK3CA DCC EP300 AKT1 AKT1 FGFR3 RAD54B CCND1 FLCN MCC ODC1 FGFR3 PIK3CA PTEN HRAS BAX SRC APC KRAS CTNNB1 BUB1 RB1 NTHL1 PDGFRL AURKA ATP7A HRAS PTPN12
Protein Mutations 1
V617F
SNP 2
rs11045585 rs12762549