SNPMiner Trials (Home Page)
Report for SNP rs1800588
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There is one clinical trial.
Clinical Trials
1 Hepatic Lipase Variant -514 C/T in a High Fat vs. Low Fat Diet for Cardio-metabolic Outcomes: A Crossover Randomized Dietary Intervention Trial
The investigators evaluated dietary modulation of LIPC rs1800588 (-514 C/T) for lipids and glucose using a randomized cross-over design comparing a high-fat Western diet and a low-fat traditional Hispanic diet in Caribbean Hispanics (n=42; 4 weeks/phase).
NCT02938091 Dyslipidemia Impaired Glucose Tolerance Other: High-fat diet Other: Low-fat diet MeSH:Dyslipidemias Glucose Intolerance
HPO:Abnormal circulating lipid concentration
Dietary Modulation of Hepatic Lipase (LIPC) -514 C/T Variant Associations With Lipids and Glucose The investigators evaluated dietary modulation of LIPC rs1800588 (-514 C/T) for lipids and glucose using a randomized cross-over design comparing a high-fat Western diet and a low-fat traditional Hispanic diet in Caribbean Hispanics (n=42; 4 weeks/phase).
Individuals were screened for LIPC rs1800588 genotype prior to enrollment, and genotype-associated differences in response to diet were evaluated.
Primary Outcomes
Measure: change in fasting high-density lipoprotein cholesterol Time: From date of randomization until completion of each 4 week dietary interventionSecondary Outcomes
Measure: change in fasting plasma triglycerides Time: From date of randomization until completion of the 4 week dietary interventionMeasure: change in fasting plasma glucose Time: From date of randomization until completion of the 4 week dietary intervention
Measure: oral glucose tolerance test Time: 2 hours post-oral glucose load
Measure: post-prandial lipemia 4 hours Time: 4 hours post-oral fat load
Measure: post-prandial lipemia 8 hours Time: 8 hours post-oral fat load