There is one clinical trial.
The two specific aims of this study are: 1) to assess the impact of a genetic variant on iron status; 2) to assess the impact of a genetic variant on non-heme absorption among Asian women. The investigators hypothesize that the genetic variant could enhance iron status and iron absorption in Asian women.
Genotype at SNP rs9366637.
Description: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining genotype.
Measure: Genotype at SNP rs9366637 Time: 2 weeks after the participant's visit to the laboratoryDescription: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of hemoglobin.
Measure: Hemoglobin Time: Up to 2 days after the participant's visit to the laboratoryDescription: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of serum ferritin.
Measure: Serum Ferritin Time: Up to 6 months after the participant's visit to the laboratoryDescription: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of serum transferrin receptor.
Measure: Serum transferrin receptor Time: Up to 6 months after the participant's visit to the laboratoryDescription: Women donated a blood sample for genotyping. Women with particular HFE genotypes were invited to return for an absorption study. Two weeks after women consume the iron tracer, a blood sample was obtained to measure the amount of iron absorbed.
Measure: Non-heme Iron absorption in women with 2 HFE genotypes Time: one month for screening with genotype then 2 weeks for iron absorption studyDescription: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of folate.
Measure: Folate Time: Up to 6 months after the participant's visit to the laboratoryDescription: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of vitamin B-12.
Measure: Vitamin B-12 Time: Up to 6 months after the participant's visit to the laboratoryDescription: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of C-reactive protein.
Measure: C-reactive protein Time: Up to 6 months after the participant's visit to the laboratory